Disha jain

31 posts

Disha jain

Disha jain

@Disha__dak

We might not hear it at times , but the music is always on.

Bengaluru, India Katılım Aralık 2020
107 Takip Edilen59 Takipçiler
Disha jain retweetledi
Kesavardan S
Kesavardan S@keshu_VRimmCh·
Why did 2.3.4.4b clade #H5N1 need a long stalk N1, unlike the previous clades H5N1s? We identified the emergence of 2.3.4.4b #H5 HA with a distinct #glycosylation pattern in its RBD that drove its preferential pairing with long stalk N1 and the emergence of this novel variant.
Kesavardan S@keshu_VRimmCh

Why did the 2.3.4.4b #H5N1 become a #panzootic virus? Given its unprecedented spread, it's important to ask this Qstn. We reported last year, 2.3.4.4b H5N1 features long stalk N1, unlike prev clades. All mammals infected with H5N1 after 2020 (also B3.13&D1.1) show long stalk N1.

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Kesavardan S
Kesavardan S@keshu_VRimmCh·
We showed some time back 2.3.4.4b #H5N1 shows long stalk (full length) N1 (NA) in birds and mammals, unlike previous H5 clades , which preferentially paired with N1 with stalk deletions (short stalk). Glad to see another study with similar observations biorxiv.org/content/10.110…
Florian Krammer@florian_krammer

The first 'Vienna' paper is out. @enikohermann did a great job with that! journals.asm.org/doi/10.1128/mb…

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Kesavardan S
Kesavardan S@keshu_VRimmCh·
How does inflammatory cell death reveal insights about Bat viral tolerance? 🦇 🦇 Check out our interesting discussion. @sci_questions @BICS_IISc @iiscbangalore
ASM@ASMicrobiology

#MicrobiologyMonday: Bats are reservoirs for many viruses but don't get as sick as humans.🦇Why? It has to do, in part, with how bats regulate inflammation & cell death mechanisms, which are associated with virus-induced immunopathology in humans. #mBio: journals.asm.org/doi/10.1128/mb…

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IISc Bangalore
IISc Bangalore@iiscbangalore·
A new study by researchers at IISc offers insights into cell death regulation by viruses like SARS-CoV-2, and how bats and humans respond differently to tricks that such viruses use to manipulate the host’s defense. iisc.ac.in/events/how-bat… #IIScresearch
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Subham Das
Subham Das@_Subham_Das·
Reservoir host species (birds and bats) often stay asymptomatic compared to humans during viral infections. Regulation of multimodal cell death pathway (PANoptosis) in bats and birds contributes to their viral tolerance. #Anantika @keshu_VRimmCh mdpi.com/1999-4915/16/1…
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Disha jain
Disha jain@Disha__dak·
New study from our lab: Decoding non-human mammalian adaptive signatures of 2.3.4.4b H5N1 to assess its human adaptive potential biorxiv.org/content/10.110…
Kesavardan S@keshu_VRimmCh

New work: Decoding non-human mammalian adaptive signatures of 2.3.4.4b #H5N1 to assess its human adaptive potential. We aim to understand the non-human mammal adaptations of panzootic 2.3.4.4b H5N1 and assess the human adaptive potential of 2.3.4.4b H5N1 biorxiv.org/content/10.110…

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Kesavardan S
Kesavardan S@keshu_VRimmCh·
#H5N1 influenza: Urgent questions and directions. Glad contributing to this with the experts @gonzamoratorio @Lakdawala_Lab @MichaelWorobey @world_epidemic @JenniferNuzzo #ShuoSu @CellCellPress What we need to know of this 2.3.4.4b H5N1 that led to unprecedented infections.
Cell@CellCellPress

New Voices Article! H5N1 influenza: We asked virologists, epidemiologists, and public health experts what the most urgent questions and action points are at this stage of the outbreak #H5N1 #birdflu #influenza shorturl.at/wples

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Kesavardan S
Kesavardan S@keshu_VRimmCh·
A Green and Bright Day at @iiscbangalore Our lab picture at IISc.!! Our group is interested in investigating the Emergence of Pandemic viruses, Reservoir host Biology, Z-RNA sensing and Cell Death. @BICS_IISc
Kesavardan S tweet media
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Kesavardan S
Kesavardan S@keshu_VRimmCh·
Our new work attempting 2 important questions: Why did 2.3.4.4b clade #H5N1 emerge as a highly pathogenic panzootic virus, which has not been achieved by previous viruses? Is the pairing of avian influenza HA and NA stochastic or molecularly programmed? biorxiv.org/content/10.110…
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Sanchita Mishra
Sanchita Mishra@SanchitaMishr20·
Unveiling mechanisms of viral pathogenesis at the interface of bats and humans ! Thanks, @DBTIndia, for featuring our study. @keshu_VRimmCh @Disha__dak
Department of Biotechnology@DBTIndia

@iiscbangalore scientists describes how pathogenic traits might evolve in bat-linked zoonotic viruses and reveal mechanisms that can be targeted to alleviate respiratory epithelial damage in respiratory virus infections. biorxiv.org/content/10.110… @DrJitendraSingh @rajesh_gokhale

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Kesavardan S
Kesavardan S@keshu_VRimmCh·
How current H5N1 strain evolved to be deadlier than the earlier strains is speculated. But, Why the current #H5N1 is deadlier than previous ones is still enigmatic.! Stay tuned for our study addressing this question that's coming up soon. nature.com/articles/d4158…
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Kesavardan S
Kesavardan S@keshu_VRimmCh·
Glad to share our study: #Bat-associated zoonotic RNA viruses operate viral RHIMs regulating cell death. Providing  possible mechanisms underlying respiratory epthelial damage and uncontrolled inflammation in respiratory virus infections. #RHIMs #cellDeath biorxiv.org/content/10.110…
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Disha jain
Disha jain@Disha__dak·
@sci_questions I am glad you liked them. We were so happy to host you. We look forward to see you soon and discuss science over dosa and coffee.
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Keşfet

@sci_questions @BICS_IISc @iiscbangalore @_Subham_Das @C_Priyansh @Rita_QT @iScience_CP @keshu_VRimmCh