Dominic Helmerich

Our new functionalized docetaxel probe enables superior visualization of dense mitotic spindle structures during cell division by expansion microscopy! | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/ja…

I am super happy to share our latest article entitled "Decoding the molecular interplay of CD20 and therapeutic antibodies with fast volumetric nanoscopy", now published in Science science.org/doi/10.1126/sc…

🚨New Paper Alert🚨Explore our latest work on the Lysosomal BrainAtlas, now available on bioRxiv! This comprehensive resource maps lysosomal proteins in specific brain cell types and identifies SLC45A1 as a novel neuron-specific lysosomal sugar transporter doi.org/10.1101/2024.1…

🚨🎉Paper alert! Finally, our paper about the combination of ISM and SMLM is out! #SMLM #ISM #FLIM Many thanks to all contributing authors ⁦@NielsRadmacher⁩, Ignacio Gallea, Ingo Gregor, ⁦@nanofein⁩, Silvio Rizzoli and Jörg Enderlein. nature.com/articles/s4156…

I've always wanted to delve into virus imaging.🦠🔬 Please check out our newest preprint, where we introduce the use of the non-human-infecting virus, bacteriophage T4, as an effective and straightforward bio-ruler for 3D super-resolution imaging.📏 biorxiv.org/content/10.110…

📢 Excited to share our new preprint "Three-dimensional multi-target super-resolution microscopy of cells using Metal-Induced Energy Transfer and DNA-PAINT"! biorxiv.org/content/10.110… #DNAPAINT #MIETPAINT #FLPAINT #SRM #MIET #FLIM @uniGoettingen A short 🧵👇

@samub28 Thanks a lot😉

Super talk by Dominic @DominicHelm !!

🆕Out now: Our latest review explores innovative site-specific protein labeling strategies, pushing boundaries in biological imaging. Dive into the nanometer scale with us in Current Opinion in Chemical Biology. ▶️doi.org/10.1016/j.cbpa… #ScienceTwitter #ProteinLabeling

My first paper at @OxfordChemistry is out in @NaturePhotonics: Single-protein optical holography! Big thanks to Emanuel Pfitzner and Philipp Kukura. We improved the sensitivity of optical holography by orders of magnitude to detect single proteins. 1/5 nature.com/articles/s4156…

🚨📢Out now: „Expansion microscopy enables 4-color fluorescence imaging of trans-synaptic protein organization.” Discover the nanocolumn arrangement @FrontNeurosci: Link ▶️: doi.org/10.3389/fncel.…

PicoRulers are new optical rulers for validating #SuperResolution #Microscopy performance. These rulers are based on the PCNA protein and use precisely positioned unnatural amino acids at 6 nm spacing, specifically labeled using click chemistry. More info: bit.ly/41aDJUf

Using Click Chemistry To Improve Viral Infection Modeling: New approach to virus visualization and labeling chemistryviews.org/using-click-ch…

NEW📰🚨:"Protein-based PicoRulers set new standards for the verification of sub-10 nm super-resolution microscopy methods under cellular conditions." ▶️onlinelibrary.wiley.com/doi/abs/10.100…

Good news for the world of high-resolution #microscopy: @unnaturalGerti @LabSauer @RVZ_Wuerzburg present biocompatible molecular rulers for calibrating the latest super-resolution microscopy methods @advscinews! ➡️ uni-wuerzburg.de/en/news-and-ev…

#Microscopy: The penetration of #viruses into cells can now be tracked with unprecedented accuracy - thanks to @LabSauer @unnaturalGerti @RVZ_Wuerzburg and their innovative design for #pseudoviruses @acsnano ➡️ uni-wuerzburg.de/en/news-and-ev…

🚨🆕"What if we could map viral infections in 3D?" Now we can! Discover our #clickVSV technology in our latest publication @acsnano: ▶️pubs.acs.org/doi/10.1021/ac… A joint effort of the labs of @GeorgGasteiger and @unnaturalGerti at @Uni_WUE #Virology #VirusResearch #Science

📢New Paper: "Expansion microscopy enables 4-color fluorescence imaging of synaptic protein organization with 20 nm spatial resolution." ➡️Here´s the link: doi.org/10.1117/1.NPh.… #FluorescenceFriday

🚨New preprint: “Two-dye imager (TDI)-DNA-PAINT allows up to 15-fold faster imaging at higher resolution and whole cell imaging in 4 hours.” ▶️Link: biorxiv.org/content/10.110…

Our new preprint is out. FL-SMLM + ISM =💪Check it here👉Doubling the resolution of single-molecule localization microscopy with image scanning microscopy biorxiv.org/content/10.110…

🔬Exciting news from our lab! Our recent paper uses #dSTORM to redefine our understanding of SARS-CoV-2 entry-receptors. Endogenous ACE2 is expressed as monomer at low densities of 1-2 receptors/µm2 in the plasma membrane❗️ ➡️onlinelibrary.wiley.com/doi/epdf/10.10…