Doris Wang

@DenaDubal @margaretgadek @ScienceAdvances @BBParis1984 Congratulations Dena! Amazing work as always!!!

"We could all use a little more X!" Thrilled our new study is out. Aging "wakes up" the silent X chromosome in the female brain - and this contributes cognitive resilience. Spearheaded by @MargaretGadek in @ScienceAdvances Collaborators Berenice Benayoun, @BBParis1984 Kaitlin Casaletto @YokoyamaLabUCSF @SimonsFdn @NIH science.org/doi/10.1126/sc…

@zixiao_yin Thank you Zixiao

Super interesting!

@SergeyStavisky @RithvikRamesh6 Thank you Sergey!

@DorisWangLab @RithvikRamesh6 Exciting!

Excited to share our latest preprint, led by @RithvikRamesh6! medrxiv.org/content/10.110… See his excellent summary below ⬇️

@DenaDubal @RithvikRamesh6 Thanks Dena!

@DorisWangLab @RithvikRamesh6 Amazing and clever and impactful work!

ICYMI…just realized this is available on YouTube: my presentation @CSRS_org a couple of years ago on research funding opportunities for #spine surgeons #neurosurgery #orthotwitter #mdphdlife #MedTwitter #Neuroscience youtu.be/h7yHmHlcJzg

Thank you @WomenInNSGY for this invitation and opportunity to hear from these amazing neurosurgeon moms about their journey in parenthood!

Which may explain why PD patients who have excessive pallidal beta synchronization show hypometric weight shift during gait initiation. Kudos to the entire team and lead author Jessica Bath for spearheading this study! #Parkinsons #neurophysiology #neuroscience #dbs

Our results provide evidence that synchronized premotor and motor cortical activities transiently couple with the globus pallidus to regulate the timing of postural responses, and local pallidal activity regulate the amplitude of postural changes during gait initiation.

We are excited to share our preprint: Pallidal and motor cortical interactions determine gait initiation dynamics in Parkinson's disease medrxiv.org/content/10.110…

Looking forward to Dr. Wang’s lecture TONIGHT on FUS in Movement Disorders for the TEAM virtual lecture series…what a treat to have this amazing neurosurgeon/researcher present on the cusp of reaching this milestone. Learn more about TEAM here: mailchi.mp/e94a6a9a7eb0/t…

100 focused ultrasound procedures done!!! Thanks to the entire amazing team and our patients! @NeurosurgUCSF @UCSFimaging @UCSFHospitals #hifu #fus #tremor

Inspiring meeting about innovations and the future of DBS! Humbled to share the stage with giants and leaders of this field. Paris, je t’aime. #DBS

Kudos to postdoc Hamid Fekri Azgomi for leading this work, and to all the coauthors, and patients!

While DBS is effective at treating many appendicular symptoms of PD, its effects on gait are variable and less predictable. Why? Because we do not have a good understanding of neurophysiology of human gait and the impact of DBS on gait.

We are excited to share our preprints: Modeling and Optimizing Deep Brain Stimulation to Enhance Gait in Parkinson's Disease: Personalized Treatment with Neurophysiological Insights medrxiv.org/content/10.110…

And finally 3) we identified physiological signatures of improved gait with DBS. This work will provide a framework for how we use neurophysiology to optimize neuromodulation to treat motor (and potentially other) symptoms of Parkinson’s Disease

Here in PD patients implanted with GPi DBS and cortical electrodes, we 1) developed a validated walking performance index to objectively measure gait metrics in PD patients 2) used a Gaussian Process Regressor to identify stimulation parameters that produce the best gait pattern