Doug Wassarman

30 posts

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Doug Wassarman

Doug Wassarman

@DougWassarman

Biochemist and Chemical Biologist Postdoctoral Research Fellow, Kranzusch Lab Dana-Farber Cancer Institute, Harvard Medical School

Boston, MA Katılım Şubat 2019
163 Takip Edilen127 Takipçiler
Doug Wassarman
Doug Wassarman@DougWassarman·
I'm so excited to share this work! We combine chemistry and genetics to inhibit mTOR in specific tissues. We hope this will be a useful tool for anybody who is interested in mTOR and rapamycin in aging, immunity, metabolism, and more! biorxiv.org/content/10.110…
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Scientists 4 Diversity
Scientists 4 Diversity@S4D_UCSF·
Thank you to everyone who came to our networking mixer on Friday and to our keynote speaker Dr. Jason Sello for emphasizing the importance of mentorship in academia and prioritizing happiness in our science. Let's continue to uplift and support each other!
Scientists 4 Diversity tweet mediaScientists 4 Diversity tweet media
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Kevan Shokat
Kevan Shokat@kevansf·
Very excited to have @bignerdzzy’s work targeting K-Ras with new bifunctional molecules published in @angew_chem. Thank you to our editor Dr. Godinho and the reviewers for their expertise and rapid reviews! @UCSFCancer @UCSF @NCIResearchCtr @DamonRunyon
Angewandte Chemie@angew_chem

@kevansf & Ziyang Zhang @UCSF describe bifunctional #SmallMolecule ligands of K-Ras that induce its association with immunophilin proteins, #DrugDesign doi.wiley.com/10.1002/anie.2…

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Seth Axen 🪓
Seth Axen 🪓@sethaxen·
Shokat lab over here crushing it with their social hour poster. @kevansf
Seth Axen 🪓 tweet media
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Martin Kampmann
Martin Kampmann@MartinUCSF·
CRISPRi-based fine-tuning of gene expression to characterize resulting phenotypes: Titrating gene expression with series of systematically compromised CRISPR guide RNAs biorxiv.org/content/10.110…
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Ryan Muir
Ryan Muir@RyanKMuir·
Take a look at my 3 minute Grad Slam talk that I gave a couple of weeks ago! Turns out the hardest part of grad school is summing up 5 years of research in only 3 minutes... #GradSlam m.youtube.com/watch?v=XzCL0h…
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Doug Wassarman
Doug Wassarman@DougWassarman·
Nice review on the role of metabolism in immune cell activation. It highlights how metabolic changes support the energetic and biosynthetic needs associated with activation of different immune cells. jbc.org/content/291/1/1
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Doug Wassarman
Doug Wassarman@DougWassarman·
This just taught me about a really cool method for protein engineering: circular permutation. Check it out! These folks use it to create caged versions of Cas9 that are activated by viral proteases and help restrict viral infectivity. sciencedirect.com/science/articl…
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Doug Wassarman
Doug Wassarman@DougWassarman·
It’s always exciting to see drug candidates with novel mechanisms of action move into clinical trials! Hopefully this is just the first of many #PROTAC
Craig Crews@CraigMCrews

Chemical Biology Comes of Age- it's been great to shepherd our academic chemical biology idea from concept to the clinic over the past twenty years. My hopes have long been for #PROTACs to have a clinical benefit for patients. Good luck @Arvinas! globenewswire.com/news-release/2…

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Keşfet

@GestwickiLab @NatureComms @salilab_ucsf @LanderLab @Andyhernandy @biorxivpreprint @bignerdzzy @angew_chem