Simon Stern

1.7K posts

Simon Stern banner
Simon Stern

Simon Stern

@DrSStern

Consultant Haematologist. Interested in haemato-oncology in general and multiple myeloma in particular.

Katılım Mart 2015
311 Takip Edilen360 Takipçiler
Simon Stern retweetledi
Dr Rishabh Jain
Dr Rishabh Jain@DrRishabhOnco·
AI reads almost everything. But medicine is still practiced in the space between evidence and judgment. That space remains profoundly human.
Vincent Rajkumar@VincentRK

AI is not a medical expert. AI is a pseudo expert. It possesses incredible a capacity to scour all of the available information and put together a coherent answer or summary. This answer or summary will greatly help the general public and physicians who are not experts in a given disease by making search, retrieval, synthesis of available information. But it’s not an expert. AI cannot be expected to know data that’s known to experts but is not yet published. It cannot know when data in published form differs from that experienced in real world practice by clinicians who see a large volume of patients with the same disease. Where the published data are wrong or exaggerate benefits or minimize risks. It cannot judge the right treatment option among similar competing treatment options (except superficially), especially based on what the patient evaluation reveals on history and examination. AI appears to be an expert in everything in the world by knowing what experts have written and made public but lacks wisdom by the very nature of how it works to produce the answer. It’s not thinking. It knows as the famous saying where the puck is but not where it’s going to be. That’s why the even the most ardent proponents of AI including the uber rich who own the models will always seek out the best human expert available for serious diseases. They may use AI to provide a summary of their disease for the expert but they are not going to mistake or substitute AI for the expert. I don’t see this changing. Because medicine is more than knowing everything that’s published or being able to retrieve it quickly. We live in a world of medicine where it’s easy to confuse pseudo experts who have gained or granted prominence with real depth of expertise and wisdom. So it’s easy to see how a lot of us are mesmerized by the speed and eloquence of AI to answer queries. Yes it does that well (and is probably sufficient 90% of the time). But as you learn how LLMs and other AI tools work you know it’s no expert, but a useful side kick. I do think it can help both experts and non experts but we must know what it’s capable of and what it’s not.

English
5
5
17
5.5K
Simon Stern retweetledi
Al-Ola A Abdallah MD (USMIRC)
Al-Ola A Abdallah MD (USMIRC)@Abdallah81MD·
1/ 🧵 ANDROMEDA final analysis is practice-changing for newly diagnosed AL amyloidosis. IMPORTANT tweets: 3/4 and 6 for clinicians who treats Amyloidosis D-VCd = daratumumab + bortezomib/cyclophosphamide/dexamethasone. With 61.4 months median follow-up, D-VCd improved depth of response, organ recovery, MOD-PFS, and OS. 🔥 #USMIRC #MedEd #medtwitter #mmsm #myeloma @USMIRCNEWS @US_HMC @MedwatchKate @Larvol @OncoAlert
Al-Ola A Abdallah MD (USMIRC) tweet media
English
5
40
114
8.4K
Simon Stern retweetledi
Sarmo ⚫️🟠
Sarmo ⚫️🟠@sarm0161·
I’m pleased to report that yesterdays VAR decision has made its ways to the hellhole that is LinkedIn.
Sarmo ⚫️🟠 tweet media
English
7
8
63
12.2K
Simon Stern retweetledi
Raj Chakraborty
Raj Chakraborty@rajshekharucms·
Glad this negative study was published by the @iStopMM group! No association of any dietary pattern with MGUS overall in this large population-based screening study. Before putting the burden of dietary intervention on our patients (beyond common sense), we must have randomized trials with clinically relevant endpoints.
Samer Al Hadidi, MD,MS,FACP@HadidiSamer

Important work @iStopMM @BloodCancerJnl #mmsm New study from iStopMM screened >75000 people for MGUS ✅ >27000 completed a food survey — 1,020 had MGUS ✅ Overall diet & dietary patterns are NOT major risk factors for MGUS(imp finding) 🛑Exception: High dairy intake was linked to 2x higher odds of IgA MGUS (OR 2.01) Bottom line: What you eat likely isn't driving your multiple myeloma risk — but dairy's role in IgA MGUS is an interesting finding ➡️ nature.com/articles/s4140…

English
1
10
34
4.6K
Simon Stern retweetledi
Paul Bronks
Paul Bronks@SlenderSherbet·
Yes you can come, just don't be weird. Me:
English
974
11.2K
67.9K
1.6M
Simon Stern retweetledi
Raj Chakraborty
Raj Chakraborty@rajshekharucms·
Grateful to @ASHClinicalNews for highlighting our article on sFLC>100 criterion for #Myeloma diagnosis! This creates two problems: Potential over-treatment of a majority of patients in a heterogeneous group & driving PFS benefit in high-risk smoldering myeloma trials by events that are not clinically meaningful!
ASH Clinical News@ASHClinicalNews

Researchers propose the removal of an sFLC ratio ≥100 as a standalone myeloma-defining event in the IMWG diagnostic criteria for #MMsm, as new findings indicate the previously cited 80% risk of disease progression at two years may be substantially lower: ow.ly/TpF750YwhlS

English
0
12
40
4.7K
Simon Stern retweetledi
Khushali Jhaveri
Khushali Jhaveri@JhaveriKhushali·
As BsAbs move into earlier lines, infection risk is the elephant in the room! Kim et al. @BloodAdvances: 75% cumulative infection rate at 24 mo. Neutropenia and low IgG drove risk, early steroids did not. IgG monitoring and timely IVIG remain key! doi.org/10.1182/blooda…
English
0
11
53
4.5K
Simon Stern retweetledi
Vincent Rajkumar
Vincent Rajkumar@VincentRK·
Just in: Good news for the myeloma field. FDA approves teclistamab plus daratumumab (Tec-Dara) combination for myeloma for patients who have had at least one prior line of therapy. Note: Always use Tec-Dara with monthly IVIG. It’s not optional. That was fast! And this is unprecedented curve is why.
Vincent Rajkumar tweet media
English
7
90
298
26.2K
Simon Stern retweetledi
-
-@HaIfTurn·
Tottenham fans next season
English
77
1.4K
12.9K
659.7K
Simon Stern retweetledi
Rahul Banerjee, MD, FACP
Rahul Banerjee, MD, FACP@RahulBanerjeeMD·
Picture worth a thousand words! @AjHematology by Mayo myeloma: RW Dara-Rd in #MMsm 1️⃣ 2/3 pts required dose ⬇️, typically #downwithdex or #downwithlen 2️⃣ Landmarked PFS unequivocally better if so My takeaway: Duration of Dara-Rd --> Dara(±R) more important than exact dose!
Rahul Banerjee, MD, FACP tweet media
English
2
6
25
2.1K
Simon Stern
Simon Stern@DrSStern·
@mancunianmedic He was a patient of mine for a few years. He had a great self-deprecating sense of humour, particularly if he didn't think much of the play/programme he was involved with when I saw him.
English
0
0
2
31
Simon Stern retweetledi
Robert Z. Orlowski
Robert Z. Orlowski@Myeloma_Doc·
#Myeloma Paper of the Day: Real-world analysis of resuming bone-modifying agents in relapsed myeloma does not show improvement in long-term survival outcomes (median PFS 10.1 vs 9.2 months; OS 39.6 vs 51.5 months for deferred vs. BMA-received pts): pubmed.ncbi.nlm.nih.gov/41733330/. #mmsm
Robert Z. Orlowski tweet mediaRobert Z. Orlowski tweet mediaRobert Z. Orlowski tweet mediaRobert Z. Orlowski tweet media
English
1
9
14
5K
Simon Stern
Simon Stern@DrSStern·
Excellent editorial by @DrRakeshPopat, re-evaluating the place of bispecific antibody therapy in the light of the groundbreaking MajesTEC-3 trial. #mmsm Biting the Tail of CAR-T for Relapsed Multiple Myeloma | New England Journal of Medicine nejm.org/doi/full/10.10…
English
0
0
9
497
Simon Stern retweetledi
Gareth Morgan
Gareth Morgan@DrGarethMorgan1·
This series of curves shows how survival in mm now almost matches the survival in the normal population the top 3 curves male female and combined
Gareth Morgan tweet media
English
0
4
14
1.2K
Simon Stern retweetledi
Tom Peck
Tom Peck@tompeck·
If you’re struggling to keep the kids happy this half term, I’m hearing a last minute table’s just become available at Woking Pizza Express.
English
7
105
2.1K
45K
Simon Stern
Simon Stern@DrSStern·
Final score: Liverpool 1 Man City 2 VAR jobsworths 1 #LIVMCI
English
0
0
1
365