Simon Stern

As BsAbs move into earlier lines, infection risk is the elephant in the room! Kim et al. @BloodAdvances: 75% cumulative infection rate at 24 mo. Neutropenia and low IgG drove risk, early steroids did not. IgG monitoring and timely IVIG remain key! doi.org/10.1182/blooda…

Just in: Good news for the myeloma field. FDA approves teclistamab plus daratumumab (Tec-Dara) combination for myeloma for patients who have had at least one prior line of therapy. Note: Always use Tec-Dara with monthly IVIG. It’s not optional. That was fast! And this is unprecedented curve is why.

Tottenham fans next season

Picture worth a thousand words! @AjHematology by Mayo myeloma: RW Dara-Rd in #MMsm 1️⃣ 2/3 pts required dose ⬇️, typically #downwithdex or #downwithlen 2️⃣ Landmarked PFS unequivocally better if so My takeaway: Duration of Dara-Rd --> Dara(±R) more important than exact dose!

@mancunianmedic He was a patient of mine for a few years. He had a great self-deprecating sense of humour, particularly if he didn't think much of the play/programme he was involved with when I saw him.

#Myeloma Paper of the Day: Real-world analysis of resuming bone-modifying agents in relapsed myeloma does not show improvement in long-term survival outcomes (median PFS 10.1 vs 9.2 months; OS 39.6 vs 51.5 months for deferred vs. BMA-received pts): pubmed.ncbi.nlm.nih.gov/41733330/. #mmsm

Fascinating bit of social history.

Excellent editorial by @DrRakeshPopat, re-evaluating the place of bispecific antibody therapy in the light of the groundbreaking MajesTEC-3 trial. #mmsm Biting the Tail of CAR-T for Relapsed Multiple Myeloma | New England Journal of Medicine nejm.org/doi/full/10.10…

This series of curves shows how survival in mm now almost matches the survival in the normal population the top 3 curves male female and combined

If you’re struggling to keep the kids happy this half term, I’m hearing a last minute table’s just become available at Woking Pizza Express.

Final score: Liverpool 1 Man City 2 VAR jobsworths 1 #LIVMCI

I didn't think the reputation of the Met Police could sink any lower, but Amanda's obsession with fitting up Jade has done it. #TheTraitors

Fantastic story thetimes.com/uk/transport/a…

#Myeloma Paper of the Day: Genomically smoldering myeloma is not a distinct entity but an amalgam of patients w/ either #MGUS (lower mutational load & absence of copy number alterations on chromosome 8) or myeloma w/ already existing driver lesions: pubmed.ncbi.nlm.nih.gov/41380103/. #mmsm

Just out! AQUILA data in smoldering myeloma by IMWG 2020 SMM risk groups. #ASH25 @PlasmaCellPete Daratumumab is FDA and EMA approved for high risk smoldering myeloma See the difference in 5 year rate of progression to Active Myeloma: Dara versus Observation

Frailty adjusted dosing for transplant ineligible myeloma patients from the UKMRA Fitness trial. Amazingly high number of frail patients entering into the study. Great talk from @_DrCP.

I am watching a film of hero-worship for Trump that would embarrass Stalin live on the BBC and courtesy of FIFA

Important work from @MyMKaiser and his team at the Institute of Cancer Research and @royalmarsdenNHS in this week's @BloodPortfolio. Challenging the concept of functional high-risk myeloma through transcriptional and genetic profiling ashpublications.org/blood/article/…

@CwynKate @ucl @uclh Many congratulations Kate - very well deserved!

Delighted to be promoted to Professor of Haematology @ucl & grateful to many fantastic colleagues @uclh , in 🇬🇧 & internationally. So many joyful collaborations that have informed my practice 👏 Grateful for huge efforts from so many trying to improve outcome for our #lymsm pts

#Myeloma Paper of the Day: Matched observational study of 2010-2021 Veterans Health Administration data finds #MGUS associated w/ higher 10-yr cardiovascular disease incidence (29.5% vs 9.7%; P<0.001) & risk (aHR, 1.70 [95% CI, 1.62-1.78]; P<0.001): pubmed.ncbi.nlm.nih.gov/41294118/. #mmsm