Joe

I wonder what percent of drugs get CP’s prior to approval? Seems like fda needs to find a way to clean this up. One of the co’s I followed had 6 or 7 filed against it. What a waste of time and resources.

$repl going to get destroyed Q is how do they push this through now and then what does this mean for others? $iova $qure $prax Is fda back to being rigid?

More jump balls in this #ncaachampionship game than any game I’ve ever seen. Pretty incredible actually.

Is BP buying smaller companies a sign that they are afraid to pull the trigger on a large deal? These small buys aren’t going to add much to their bottom lines. Others are starting to print $ or have deeper pipes/indications: $slno $lqda $rvmd $bbio

Read more trib.al/Fkq8HnS ⬇️

Like I said. $tern seemed too strong. Always going higher despite the day’s pattern. But $6B is a joke unless you add a $2B+ CvR

Well, $ikt goes $2.02 to $1.84 in a day. Shorts have it right. But LT its still a great play IMO. All bios weak except for those acting like they are gonna go, à la $tern P3 should start soon. Maybe gives the bounce we need. Like $slno it’s a head scratcher.

I know every tweet is about the war but anyone have any thoughts on why $ikt SI went up 60%? $goss fail likely proves PoC & they are about to start P3. I suppose some shorted when it hit $2.50 but 60% inc seems peculiarly high.

Hard to not want to buy bios at these prices. But I’ll wait. Not sure things get better anytime soon. Doing nothing or even selling (if you can) may be more practical. We will rally whenever this is really over but until then, you can feel the overhang.

Researchers at UC Irvine took saliva samples from a choir before and after performing Beethoven. One antibody, the most abundant in your entire body, spiked 240%. That antibody is called secretory immunoglobulin A. Mouthful of a name, but it does a simple job: it coats your throat, gut, and airways and acts as your body’s first barrier against every cold, flu, and respiratory virus you breathe in. Your body makes more of it than all other antibody types combined. The 2000 study found this antibody rose 150% during rehearsals and 240% during the live performance. A separate 2004 study from the University of Frankfurt tested what happens when choir members just listen to the same music instead of singing it. The antibody barely moved. And their mood actually got worse. Marathon runners show the exact opposite. A study of 98 competitive runners found this same antibody dropped 21 to 31% after the race. 17% came down with colds or throat infections within two weeks. Cross-country runners tracked over a full season saw it fall to 40% of their starting level by November. Running was suppressing the same antibody that singing was tripling. It works through the vagus nerve, the longest nerve in your body. It runs from your brain down through your chest to your gut and controls your “rest and digest” mode. When you sing, your vocal cords physically vibrate against it where it wraps around your voice box. You’re also breathing from deep in your belly with long, slow exhales, which tells your nervous system to calm down. Your stress hormones drop. Your immune system responds. A 2016 study from the Royal College of Music and Imperial College London tested 193 cancer patients and carers across five choirs in South Wales. One hour of group singing lowered cortisol (the body’s main stress hormone) and raised five different immune signaling proteins. The people with the worst depression scores improved the most. You don’t need to be good at it. The boost comes from the physical act, the vibration and the breathing, not the melody. Trained soprano or shower singer, your body responds the same way. One caveat: that 240% number came from a live performance, where adrenaline and emotional intensity were at their peak. Singing along to the radio probably produces a smaller spike. And these are temporary boosts, not permanent changes. But the 193 cancer patients in the 2016 study weren’t performing Beethoven on stage. They were just singing together for an hour in community choirs.

@SnupSnus @ImtiazMadmood @DrPaulyDeSantis Start to finish can be an hour or two if you have a milling machine. Prep takes under 20 minutes usually but can be faster if you are experienced or do multiple teeth. Lots of nuance.

@ImtiazMadmood @DrPaulyDeSantis @Drchik23 crown doesn't take two hours does it?

In a landmark medical technology milestone, a fully autonomous AI-powered robotic dentist — built by US company Perceptive — completed a full crown preparation on a human patient in just 15 minutes. The same procedure typically takes a human dentist 2–2.5 hours. The robot used real-time 3D scanning, AI decision-making, and a precision robotic arm to perform the entire procedure without any human guidance or intervention mid-surgery. This isn't a concept or prototype — it's already been performed on real patients and a peer-reviewed study was published in the Journal of Dentistry in January 2026. Experts say this is the beginning of a transformation: robotic dentists could eliminate human error, work at any hour, and eventually bring high-quality dental care to remote and underserved communities where trained dentists are unavailable. The dental office of 2035 may look very different from today's.

FWIW options this week have seen positive flows in $nktr & $rvmd and slight negative in $abvx

Arizona UConn Iowa State and Florida are my final four. Let’s see what happens? GL everyone.

BREAKING🚨: ALL FIVE types of nucleic acid bases, the building blocks of LIFE 'DNA and RNA', have been found in samples collected from asteroid Ryugu

@Biotech2k1 👍

I am doing an open post. I usually only make it so that people I follow can reply. That is to keep out all the bots. If you like to talk biotech, and want me to follow you please reply and I will gladly follow you.

Well, we go small M&A today $dawn but #4 is now a done deal. So let’s see which way the wind blows Monday? $xbi $clpt $qure $capr

There are a few things that can lift all $xbi boats: 1. Big M&A 2. Lowering of interest rates 3. Sector rebalancing 4. VP getting fired from FDA… again.

Sometimes a secondary really puts a floor in a stock’s price. Other times it sure doesn’t $crvs Also, is there a stock that fades any better than $lqda ? Really need that court case to end. The overhang on PPS is like gravity on earth.

@DewDiligence Thx for letting me know. I was just agreeing that $abus drop was weird. They own -20% genvant so really was a $2.5B settlement and then they did the huge buyback. But I guess market disagreed.

@Drchik23 I could not read the DMs you sent me due X’s switchover from unencrypted to encrypted messages.

$uthr COO gives Cowen presentation but Martine (ceo) sells > $100M in stock. Yet bullish option flow in $uthr at same time. Bunch of calls BTO #mixed signals or possibly short insuring position with calls? $lqda

$ocul up $fulc down $ntla up $abvx down $uthr up $lqda down $bhvn up $rvmd down Black is white Up is down I feel like I’m getting everything wrong these days.

@adamfeuerstein Tbf DMD affects kids. So that was always hard to overlook. But one has to wonder how much $srpt ‘s failure contributed to this. Had their confirmatory trial proven efficacious would $qure be allowed to file? Bias can effect us all, even FDA

The Duchenne muscular dystrophy patient & advocacy community keeps a gene therapy and multiple drugs on the US market, stopping the FDA from taking action, despite failed confirmatory clinical trials showing no efficacy and questionable safety. The Huntington's disease patient and advocacy community can't even persuade the FDA to allow a filing of a gene therapy, despite a positive clinical trial.