ECOG-ACRIN Cancer Research Group

ECOG-ACRIN study IDs disparity in acute myeloid leukemia (AML): "We saw that Black race was an independent predictor of inferior survival in patients with AML treated on clinical trials with intensive chemotherapy." -Dr. Saint Fleur-Lominy ascopost.com/news/march-202… via @ascopost

#ComboMATCH Treatment Trial E5, led by @kspencer725 of @Perlmutter_CC and @DocDustyD of @UWCarbone, is a randomized phase 2 study of #sotorasib with or without #panitumumab in advanced #SolidTumors. Learn more here: bit.ly/combomatch-e5 #PrecisionMedicine

#ClinicalTrial EA7211/STRASS 2, led in the US by @kencardonaMD, is the second randomized study ever performed in retroperitoneal soft tissue #sarcoma & is enrolling patients in the US, Europe, Canada, Australia, New Zealand, & Japan! Learn more: bit.ly/EA7211

Why does #BreastCancer come back after treatment? The EA1241 #ClinicalTrial, led by @jsparano, aims to find out by evaluating tissue samples from patients who previously enrolled in TAILORx & RxPONDER. More: bit.ly/EA1241 cc: @KalinskyKevin, @RimapatelMD

#FindingsFriday: New research on #LungCancer trials shows 89% of patients participated in at least 1 biospecimen study, offering crucial insights for #TranslationalResearch. But participation isn’t equal & addressing gaps is essential. Read more: bit.ly/40OMLqU

The MM1OA-EA02 clinical study is testing a new treatment approach for patients with #AcuteMyeloidLeukemia who are age 60 or older. Learn more: bit.ly/mm1oa-ea02-stu… #AML #leukemia

The EAF223/GABLE clinical study is testing different imaging techniques that could help make better predictions about #BrainCancer progression. Learn more here: bit.ly/gable-trial cc: @DukeRadiology, @glioblastf, @gbmfoundation

March is #MultipleMyelomaAwareness Month, a time to recognize three clinical trials that are expanding treatment options for multiple myeloma. Learn more: EAA173/DETER-SMM, bit.ly/eaa173detersmm EAA181/EQUATE, bit.ly/eaa181equate EAA241, bit.ly/EAA241

#ClinicalTrial EA2222/PUMP, led by @michael_lidsky, is a randomized phase 3 study of #SystemicTherapy with or without hepatic arterial infusion for unresectable #Colorectal liver metastases. More here: bit.ly/ea2222-pump cc: @MichaelDAngeli2, @skmaithel, @AndreaCercek

#ClinicalTrial EA8231, led by @MonikaJoshimd & @PGrivasMDPhD, is a phase 3 randomized study exploring a new treatment approach for patients with treatment-refractory, locally-advanced or metastatic #UrothelialCancer. More information here: bit.ly/ea8231-study

Have you had surgery for squamous cell carcinoma of the head and neck (#HNSCC) that has come back? If so, you may be able to participate in this study of a potential new treatment. Learn more: bit.ly/ea3191-study #HeadAndNeckCancer #HNCA

#ClinicalTrial EA7222, led by @immunosarc, is a randomized phase 3 trial of doxorubicin alone or in combination with pembrolizumab for patients w/ advanced soft tissue #sarcoma and related poorly differentiated sarcomas that are unresectable. bit.ly/EA7222

ICYMI: Watch this new video on the EA8231 #ClinicalTrial for patients with advanced #UrothelialCancer. @MonikaJoshimd & @PGrivasMDPhD discuss the rationale, eligibility, & potential impact. View here: bit.ly/ea8231-video #BladderCancer

Do you have early-stage #melanoma and are age 75 or older? If so, you may be eligible to participate in this study of a potential new treatment approach. More info: bit.ly/ea6244-study #SkinCancer #MelanomaResearch

The #ComboMATCH Study, led by researchers from @StanfordCancer, @MDAndersonNews, & @theNCI, is testing new combinations of anti-cancer drugs, based on characteristics found in patients’ tumors or blood. Learn more: bit.ly/ComboMATCH #PrecisionMedicine

#ClinicalTrial EA4231, led by @MelanicjMD of @theNCI, is testing the effectiveness of a combination #TargetedTherapy for patients with aggressive B-cell #Lymphoma that has recurred or is resistant to treatment. For more: bit.ly/EA4231 cc: @BloodCancerUtd, @lymphomahub

EA8192, led by @JCensits and @PGrivasMDPhD, is a phase II/III #clinicaltrial of durvalumab and chemotherapy for patients with high grade upper tract urothelial cancer prior to nephroureterectomy. For more: bit.ly/ea8192-trial #blcsm

It’s not enough to publish breakthroughs; we must ensure they are understood. Ulrich et al. discuss the challenges of public health literacy in #oncology. Researchers have a responsibility to communicate findings in ways that resonate. More: bit.ly/4lMuRi8 @JAMAOnc

ComboMATCH/EAY191-E5 tests how well #sotorasib with or without #panitumumab can treat patients with advanced #SolidTumors. For more information: bit.ly/combomatch-e5 cc: @NCItreatment, @kspencer725, @DocDustyD #PrecisionMedicine

In clinical trial EA7211/STRASS 2, investigators are testing neoadjuvant chemotherapy followed by surgery vs. surgery alone for patients with high-risk retroperitoneal #sarcoma. More info: bit.ly/EA7211