Estonian Biobank

✨ A new star allele was born! Excited to share our first in vivo pharmacokinetic recall study involving 114 participants from @ESTbiobank with previously uncharacterised variants in CYP2C19 and CYP2D6: nature.com/articles/s4152… #Pharmacogenomics #PharmVar #ClinPGx

Mõnikord peetakse geenivaramut ekslikult tervishoiuasutuseks. Millist rolli täidab geenivaramu tegelikult Eesti tervishoiu innovatsioonis? epl.delfi.ee/artikkel/12041…

🚨 New preprint out! We reconstructed parental haplotypes in >440k individuals (UK & Estonian biobanks) to estimate assortative mating directly in the parental generation. This reveals intensified assortment in recent generations. 🔗biorxiv.org/content/10.110…

Great news! Our Associate Professor of Neuropsychiatric Genomics, Kelli Lehto, has been selected to receive the European Research Council grant! 💐Congrats on that outstanding achievement! 👉ut.ee/en/news/erc-gr…

A study of genetic effects on adverse events from antidepressants in the Estonian Biobank: CYP2C19 and polygenic risk scores. @ESTbiobank @MilaniLili @HannaKariis nature.com/articles/s4143…

🚨 Our parent-of-origin study is out in @Nature ! 🧬 Maternal and paternal alleles can have distinct — even opposite — effects on human traits, revealing a hidden layer of genetic architecture that standard GWAS miss. 🔗nature.com/articles/s4158… Highlights below!

🎉 Excited to share that our latest paper is now published! We investigated genetic factors linked to antidepressant side effects in 13,000 individuals from the @ESTbiobank, leveraging data from questionnaires and clinical notes using NLP. shorturl.at/3tAkg

A study in @NatureMedicine provides a cross-trait atlas of genetic and phenotypic associations across 42 female reproductive health diagnoses. go.nature.com/3YldiLt 🔒

Excited to share our recently published overview of the @ESTbiobank 🧬 We highlight the unique features of the biobank and the conducted scientific research, including the many recall studies that have been carried out over the years: nature.com/articles/s4146…

💡Can we use real world drug purchase data to study the genetics of medication dosing? We explored this by analyzing 20 years of digital drug dispensing data linked to the @ESTbiobank which hosts 212,000 genotyped participants. 🧵 📄 doi.org/10.1101/2025.0…

Tremendous work by @PujolGualdo @TLaisk and team! 👏🏼👏🏼👏🏼

New paper out: microbiome and causal inference! Let us tell you a bit more:

🧬🧠Recent research @ESTbiobank @genomicstartu revealed that high genetic liability to #ADHD raises risks for 80 health conditions like #COPD (+70%), #obesity (+60%) & type 2 diabetes #T2D (+45%) - even without an ADHD diagnosis. Better screening & awareness for adults is needed!

1/n Our multi-ancestry #GWAS meta-analysis of major depression is now published in @CellCellPress. cell.com/cell/fulltext/… A thread 🧵:

Delighted to accompany President Dr. @MMuizzu on his visit to the @unitartu Institute of Molecular and Cell Biology, today. We were warmly welcomed by Professor @MilaniLili, Head of Estonian Biobank & Professor of Pharmacogenomics and had an inspiring exchange on advancing digital health and genetic research. @ESTbiobank @genomicstartu

We are delighted to contribute with Estonian Biobank data to this massive collaboration 🎉 So glad to see this work published!

This is what happens when you return research results to biobank participants: ✅The 2nd most googled “How to…?” question in Estonia 2024: “How to become a biobank participant?” ✅"Estonian Biobank" among Top10 search terms. Huge thanks to all at @ESTbiobank & @genomicstartu ✨

🦠 Excited to share our new collection of human gut #archaea species! 🎉 🇪🇪From @ESTbiobank, we present a dataset of 144 strains across 21 species, including 9 entirely new species! A thread 🧵 #MAG #EstMB #TartuMicrobiome #microbiome #humangut

In @Laboratorynews, I discuss the role of biobanks in revolutionising precision medicine. 🧬   I explain how the @ESTbiobank is using genomic insights to better understand the factors influencing public health and disease.   Read more, here 👉bit.ly/3ON6xNy   #Biobanks

🚨 Our preprint on parent-of-origin effects (POEs) is out! With our new method, we inferred the parental origin of >220,000 individuals, revealing new insights into the genetic architecture of complex traits. 👉 Read here: medrxiv.org/content/10.110… 👇 Highlights below!