Emil Thomasen

32 posts

Emil Thomasen

Emil Thomasen

@EmilThomasen

Computational structural biology. Postdoc at Flatiron Institute.

New York, NY Katılım Mart 2012
221 Takip Edilen179 Takipçiler
Emil Thomasen retweetledi
Kresten Lindorff-Larsen
Kresten Lindorff-Larsen@LindorffLarsen·
New preprint in which we built and simulated full-length models of α-Synuclein fibrils to reveal how the fuzzy coat mediates selective binding of peptides to amyloid fibrils Work led by Carlos Pintado-Grima in a nice collaboration with Salvador Ventura's lab
Kresten Lindorff-Larsen tweet media
bioRxiv Bioinfo@biorxiv_bioinfo

Full-Length Molecular Models of Brain-Derived α-Synuclein Fibrils Reveal a Fuzzy-Coat-Mediated Mechanism for Selective Peptide Binding biorxiv.org/content/10.648… #biorxiv_bioinfo

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Emil Thomasen retweetledi
Sonya
Sonya@sonyahans·
Announcing cryo-EM heterogeneity challenge #2, now dubbed the 2025 Community-Wide Assessment of Cryo-EM Heterogeneous Reconstruction Algorithms (CAHRA)! Join us for a webinar next Friday (Nov 14th) to learn more. Datasets already posted here: heterogeneity.notion.site/challenge
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Emil Thomasen retweetledi
Pétur Heidarsson
Pétur Heidarsson@Heidarsson_lab·
Exciting news! I am grateful and thrilled to join the Section for Biomolecular Sciences #UCPH. We use single-molecule tools to study how pioneer factors interact with chromatin and promote cell reprogramming. Join our ERC-project PIONEER, now recruiting on all levels!⬇️
Pétur Heidarsson tweet media
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Emil Thomasen
Emil Thomasen@EmilThomasen·
I'm very happy to have defended my PhD thesis. I want to thank @CarloCamilloni, @ProteinMagnus, and @aelangkilde for a great discussion on integrative modelling in my defense, and thanks to @LindorffLarsen, SBiNLab, and our collaborators for making the PhD a great experience.
Kresten Lindorff-Larsen@LindorffLarsen

Big congratulations to @EmilThomasen on successfully defending his PhD today 🎓 🎉 🍾 🍿 🥃 And thanks to opponents @CarloCamilloni, @ProteinMagnus & @aelangkilde for leading an excellent discussion on integrative modelling, coarse grained models, and the future of the field 🙏

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Emil Thomasen retweetledi
Kresten Lindorff-Larsen
Kresten Lindorff-Larsen@LindorffLarsen·
CALVADOS is on Colab. Run a coarse-grained simulation of your favourite IDR in 5–30 mins (depending on length of protein and simulation) using just sequence and conditions as input. colab.research.google.com/github/KULL-Ce…
Kresten Lindorff-Larsen tweet media
Kresten Lindorff-Larsen@LindorffLarsen

If your favourite IDR is missing from the IDRome, you can generate your own ensemble using a Colab implementation of our CALVADOS model (or use the machine learning model we present in the paper to predict chain compaction from sequence). colab.research.google.com/github/KULL-Ce…

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Emil Thomasen
Emil Thomasen@EmilThomasen·
Happy to share our new paper on self-consistently determining the oligomeric states and conformational ensembles of SPOP using SAXS and MD simulations. Check out @LindorffLarsen's thread for a quick overview of the work.
Kresten Lindorff-Larsen@LindorffLarsen

How do you analyse SAXS data of a system when it shows both conformational and compositional heterogeneity? For the answer, see work led by @EmilThomasen out in @eLife, where we determine conformational ensembles of the self-associating protein SPOP. 1/n doi.org/10.7554/eLife.…

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Keşfet

@LindorffLarsen @LabVanni @SkaalumTorur @sriraksha616 @asmolsim @ProteinMagnus @aelangkilde @smnlssn