Endocrine Pathology

Interesting #EndoPath data? Send us your article! Fast turn around & expert reviewers! Make our journal your voice! link.springer.com/journal/12022

New research from the journal highlights that Ki67-based grading (G1–G3) may better predict outcomes in pulmonary NETs than current carcinoid classification, supporting a shift toward a more precise, clinically relevant system. 🔬📊 link.springer.com/article/10.100…

An image in @EndoPath details a 40-year-old woman with a rapidly enlarging thyroid nodule and lymph node metastases. Histological analysis revealed a malignant small round blue cell tumor, leading to a diagnosis of thyroblastoma. bit.ly/4vvlAPS

Cortex deep-dive! CYP11B2-guided NGS identifies higher frequency of aldosterone-driver mutations in APM from primary aldosteronism vs donor adrenals, with CACNA1D predominating. APM genotype also associates with coexisting lesions and surgical outcomes. link.springer.com/article/10.100…

A nationwide study of familial small intestine neuroendocrine tumors reveals distinct features - more frequent multifocal tumors & carcinoid syndrome - yet similar prognosis to sporadic cases. Key insight: biology differs, outcomes don’t. link.springer.com/article/10.100…

Research published in @EndoPath presents genetic insights from adrenal tumors in a MEN1 patient. The study identifies mutations in TP53 and NF1 linked to malignancy, raising awareness of increased cancer risk in MEN1 patients. bit.ly/3N26OyS

Whole-exome sequencing of adrenal tumors from a MEN1 patient reveals shared mutations between adenoma and carcinoma, suggesting a possible biological link - read it here: link.springer.com/article/10.100…

RAS mutations are common in thyroid nodules, but what do they mean clinically? In 354 nodules, isolated RAS was often linked to benign/low-risk lesions, while RAS + additional mutations (e.g., EIF1AX, TERT) significantly increased tumor aggressiveness. link.springer.com/article/10.100…

Peer review is the foundation of high-quality pathology research. We thank the reviewers recognized in this issue of Endocrine Pathology for their expertise, rigor, and commitment to advancing the field. Your work strengthens every paper we publish. 🔬 link.springer.com/article/10.100…

Pediatric adrenocortical carcinoma is not just “small adult ACC.” Different biology, different prognosis - and major therapeutic consequences for children. This review highlights why accurate pathologic assessment matters more than ever! link.springer.com/article/10.100…

Can histoarchitecture predict genotype in paragangliomas? In this study of 104 PGLs, AI-based analysis of reticulin architecture accurately predicted germline cluster 1 status, bridging histopathology and molecular classification. Read more: link.springer.com/article/10.100…

New article highlight! EBV-positive neuroendocrine carcinoma of the nasopharynx shows a distinct, high-TMB genomic profile with potentially actionable alterations - supporting recognition as a unique disease entity. link.springer.com/article/10.100…

🔬New in Endocrine Pathology! Proteomic analysis of bilateral macronodular adrenocortical disease, a rare cause of Cushing syndrome, identifies 3 distinct protein patterns linked to pathology and genetics - opening new diagnostic perspectives. link.springer.com/article/10.100…

@EndoPath reports on EBV-positive neuroendocrine carcinoma of the nasopharynx, a rare cancer with distinct molecular features. Whole-exome sequencing reveals high mutational burden and key mutations in TP53, APC, and PROK2. bit.ly/4sXLF8W

New in Endocrine Pathology! A fascinating case of a non-invasive follicular cell-derived spindle cell thyroid neoplasm with an NRAS p.Q61R mutation - expanding what we think we know about thyroid tumors! 👩🏻‍⚕️👨🏻‍⚕️ Read more ➡️ link.springer.com/article/10.100… #PathTwitter

A study in @EndoPath analyzes protein signatures in bilateral macronodular adrenocortical disease (BMAD) using LC-MS/MS. Findings reveal three distinct proteomic groups linked to microscopic and molecular characteristics. bit.ly/3ZeR51G

🧬 New research in our journal! Mismatch repair (MMR) deficiency is rare (2.2%) in pituitary neuroendocrine tumors, but reduced MMR expression is seen in specific aggressive subtypes - especially functioning corticotroph and invasive lactotroph tumors. link.springer.com/article/10.100…

A new study compares focus quality across three whole-slide scanners for thyroid cytology! An automated Laplacian variance score helped detect out-of-focus areas, especially in 3-D cell clusters, and may support scanner choice and quality control. link.springer.com/article/10.100…