Endocrine Pathology

Interesting #EndoPath data? Send us your article! Fast turn around & expert reviewers! Make our journal your voice! link.springer.com/journal/12022

Are gallbladder neuroendocrine tumors really aggressive? A new study in Endocrine Pathology suggests most GB-NETs are small, low-grade, and indolent, with tumor size and grade emerging as key predictors of metastatic risk. link.springer.com/article/10.100…

How does adrenocortical carcinoma become metastatic? New research suggests that widespread chromosomal alterations occur early and are retained throughout tumor evolution, identifying chromosomal instability as a key driver! Read more: link.springer.com/article/10.100…

Is it time to move beyond the typical/atypical carcinoid classification? Using data from >700 pulmonary NETs, researchers developed a reproducible grading system (Ki-67 and mitotic count) that outperformed traditional histology in predicting outcome. link.springer.com/article/10.100…

New molecular insights into GEPNET G3: Multi-omic profiling shows these tumors are biologically distinct from neuroendocrine carcinomas, retain features of well-differentiated NETs and harbor potentially actionable alterations in 25% of cases. link.springer.com/article/10.100…

66,000+ thyroid nodules. 132 studies. One clear message: molecular testing reduces unnecessary surgery for indeterminate thyroid nodules without compromising cancer detection. Second-generation platforms deliver the greatest benefit. link.springer.com/article/10.100…

Can AI identify PitNET lineage from routine H&E slides alone? An attention-guided neural network achieved high scores and uncovered lineage-specific morphologic patterns, highlighting the potential of AI to support pituitary tumor classification. link.springer.com/article/10.100…

Can age influence outcome in poorly differentiated thyroid carcinoma? In this study of adults ≤45 years, PDTC showed surprisingly favorable outcomes despite high-grade histology. Distinct molecular features may potentially underlie the improved survival. link.springer.com/article/10.100…

New study by @PathDocBoston and team: Among 324 thyroid tumors of uncertain malignant potential (UMP) diagnosed over 20 years, no recurrences or metastases were observed, even after up to 15 years of follow-up. Findings support conservative management! link.springer.com/article/10.100…

New research from the journal highlights that Ki67-based grading (G1–G3) may better predict outcomes in pulmonary NETs than current carcinoid classification, supporting a shift toward a more precise, clinically relevant system. 🔬📊 link.springer.com/article/10.100…

An image in @EndoPath details a 40-year-old woman with a rapidly enlarging thyroid nodule and lymph node metastases. Histological analysis revealed a malignant small round blue cell tumor, leading to a diagnosis of thyroblastoma. bit.ly/4vvlAPS

Cortex deep-dive! CYP11B2-guided NGS identifies higher frequency of aldosterone-driver mutations in APM from primary aldosteronism vs donor adrenals, with CACNA1D predominating. APM genotype also associates with coexisting lesions and surgical outcomes. link.springer.com/article/10.100…

A nationwide study of familial small intestine neuroendocrine tumors reveals distinct features - more frequent multifocal tumors & carcinoid syndrome - yet similar prognosis to sporadic cases. Key insight: biology differs, outcomes don’t. link.springer.com/article/10.100…

Research published in @EndoPath presents genetic insights from adrenal tumors in a MEN1 patient. The study identifies mutations in TP53 and NF1 linked to malignancy, raising awareness of increased cancer risk in MEN1 patients. bit.ly/3N26OyS

Whole-exome sequencing of adrenal tumors from a MEN1 patient reveals shared mutations between adenoma and carcinoma, suggesting a possible biological link - read it here: link.springer.com/article/10.100…

RAS mutations are common in thyroid nodules, but what do they mean clinically? In 354 nodules, isolated RAS was often linked to benign/low-risk lesions, while RAS + additional mutations (e.g., EIF1AX, TERT) significantly increased tumor aggressiveness. link.springer.com/article/10.100…

Peer review is the foundation of high-quality pathology research. We thank the reviewers recognized in this issue of Endocrine Pathology for their expertise, rigor, and commitment to advancing the field. Your work strengthens every paper we publish. 🔬 link.springer.com/article/10.100…

Pediatric adrenocortical carcinoma is not just “small adult ACC.” Different biology, different prognosis - and major therapeutic consequences for children. This review highlights why accurate pathologic assessment matters more than ever! link.springer.com/article/10.100…

Can histoarchitecture predict genotype in paragangliomas? In this study of 104 PGLs, AI-based analysis of reticulin architecture accurately predicted germline cluster 1 status, bridging histopathology and molecular classification. Read more: link.springer.com/article/10.100…

New article highlight! EBV-positive neuroendocrine carcinoma of the nasopharynx shows a distinct, high-TMB genomic profile with potentially actionable alterations - supporting recognition as a unique disease entity. link.springer.com/article/10.100…

🔬New in Endocrine Pathology! Proteomic analysis of bilateral macronodular adrenocortical disease, a rare cause of Cushing syndrome, identifies 3 distinct protein patterns linked to pathology and genetics - opening new diagnostic perspectives. link.springer.com/article/10.100…