Alex Couce

1/7 Excited to share our new preprint! @JFriedman_micro @EvolSys We explored evolutionary rescue in microbial communities, focusing on how obligate mutualisms respond to environmental changes. #MicrobialEcology #EvolutionaryBiology

@RELenski @benjaminhgood Very interesting discussion! Also, to this point on increased DR and sign epistasis, note that the most beneficial mutations we see on the ancestor show a great tendency to cluster together in operons - so it makes sense that most of them would be redundant if combined (Fig. 3B)

Nice work @EvolSys @ten_olivier! Curious how the #'s match up w/ DFEs estimated from fitness data (e.g. academic.oup.com/genetics/artic…). It's interesting how similar the 2K & 15K dist'ns are, given their big differences in rate of adaptation. How do we rationalize this difference?

Si quereis conocer más detalles, éste es el hilo en inglés escrito por el propio @RELenski, donde podréis encontrar enlaces a los manuscritos originales: twitter.com/RELenski/statu…. Fin del hilo.

A nivel práctico, toda vez que las grandes adaptaciones iniciales son a menudo las que marcan la diferencia entre la supervivencia y la extinción, nuestros resultados suponen una inyección de moral a los esfuerzos para predecir la evolución de patógenos (p. ej, @nextstrain).

Esta semana dos trabajos han ampliado nuestra comprensión de cómo el efecto de las mutaciones varía a lo largo de la evolución. Los estudios han sido posibles gracias un experimento que lleva >30 años evolucionando bacterias en el laboratorio. Un hilo.

@DrMikeWiser @baym @ten_olivier Yeah, I guess @barricklab and @RELenski got it covered...

@EvolSys @baym @ten_olivier Thankfully, without planned obsolescence.

I'm thrilled to share the latest preprint from my lab, a huge effort led by @anuraglimdi over the last few years. But this thread isn't just about the science we found, it's also about how we managed to do it in the way we wanted science to be practiced 1/ biorxiv.org/content/10.110…

@baym @ten_olivier In this way the LTEE is like the Hubble Space Telescope, different groups can focus on way different questions, on way different timescales...

@baym @ten_olivier Agree. Also, with such large datasets, you feel the need to kinda touch on everything. Coordinating efforts made both groups to focus and dig deeper into what really motivated each one: fragility and robustness to you, epistasis and predictability to us.

@baym Yep, it was an special and inspiring meeting... Kudos to you for taking the first step!

While either group could have scooped one another, what we did instead was have some of the most fun scientific calls I’ve ever been part of, in which we discussed our work and our results, and even cross-reviewed each other’s manuscripts. 13/

Recent recorded lecture from Alex Couce @EvolSys "Evolutionary consequences of biased mutation ... youtu.be/loh5KLSZpzs