Finn K. Hansen

Discovery of Histone Deacetylase 8-Specific Proteolysis-Targeting Chimeras with Anticancer Activity against Hematological Malignancies | Journal of Medicinal Chemistry pubs.acs.org/doi/10.1021/ac…

Happy to share our new review on the crosstalk between #NLRP3 signaling and #HDACs in #inflammasome driven diseases, just published in #JMedChem. Congrats to my postdoc and first author Kathrin, and all collaborators! pubs.acs.org/doi/10.1021/ac…

Happy to share our newest paper. Congrats to first author Irina! Slow-Acting HDACi are still puzzling!!! Congrats also to Tao, Nisha and Linda for their important controbutions to this project. pubs.acs.org/doi/10.1021/ac…

@HartungIngo Ass ball instead of air ball 😉

The definition of a no-look-pass…

Happy to share our publication dealing with the targeted #HDAC degradation via direct DDB1 recruitment. Congrats to first author Shiyang @Vincent_SYZ and everybody involved. Great collaboration with the Geyer lab @Geyer_lab! #BonnTPD pubs.acs.org/doi/10.1021/ac…

Happy to share the latest publication from my lab: we developed a NanoBRET based target engagement assay for HDAC6. Furthermore this system allows to track the HDAC6 degradation by PROTACs in real-time. Congrats to my postdoc Maria and everybody involved.pubs.acs.org/doi/10.1021/ac…

Enhancing Solubility in VHL-Based PROTACs: Optimized USP7 Degraders for Improved Developability | Journal of Medicinal Chemistry pubs.acs.org/doi/10.1021/ac…

The University of Bonn offers two PhD scholarship financed by the DAAD within the DAAD-GSSP Programme. The PhD students will be associated to the Research Training Group RTG/GRK 2873 @grk2873 Apply now! Please RT. grk2873.uni-bonn.de/en/training-pr…

Happy to see our dual HDAC6/10 #PROTAC paper out in #JMedChem. I am extremely proud of my PhD student Shiyang @Vincent_SYZ for making this possible. Huge thanks to all collaborators and co-workers for their amazing contributions! pubs.acs.org/doi/10.1021/ac…

Thrilled to see Our FerroTac story is now out at @J_A_C_S - Huge congrats 🙌🏻 🥳 @ales_salerno Lianne and Claudia! @UoDCeTPD

#ChemMedChem Replacing a Cereblon Ligand by a DDB1 and CUL4 Associated Factor 11 (DCAF11) Recruiter Converts a Selective Histone Deacetylase 6 PROTAC into a Pan-Degrader (Finn K. Hansen and co-workers) #openaccess 🔓 onlinelibrary.wiley.com/doi/10.1002/cm…

Happy to share the final version of our DCAF11-recruiting #HDAC #PROTAC paper. Congrats to my co-workers Felix @fellerflix, Heiko, Martina, Irina and Maria! …mistry-europe.onlinelibrary.wiley.com/doi/10.1002/cm…

The next chapter of our HDAC #PROTAC story: CRBN-recruiting PROTACs based on a non-selective ethylhydrazide #HDAC warhead induce selective HDAC6 degradation. Congrats to my PhD students Daniel @danicious & Irina (co-first authors), and Felix @fellerflix. pubs.acs.org/doi/full/10.10…

Thrilled to share our #JMedChem paper dealing with DS-103! The ethylhydrazide DS-103 fully reverses cisplatin resistance and binds to HDAC6 in a manner similar to a hydroxamate. Huge congrats to first authors Daniel @danicious & Lukas and the entire team! pubs.acs.org/doi/10.1021/ac…

Happy to share our latest paper in #JMedChem on improved antagonists targeting the intracellular allosteric binding site of CCR7! Huge thanks and congratulations to the whole team for the incredible teamwork! pubs.acs.org/doi/10.1021/ac…

Excited to share our latest publication on #HDAC inhibitor-based multineurotarget drugs as a potential treatment option for Alzheimer´s disease, now online in ACS Pharmacology & TS! 🎉 Huge congrats to our amazing team and collaborators! pubs.acs.org/doi/full/10.10…

New #PROTAC preprint: In this work, we utilized a non-selective ethyl hydrazide warhead for the selective HDAC6 degradation. Congratulations to co-first authors Daniel @danicious & Irina as well as Felix @fellerflix ! go.shr.lc/4jinjC0

@IzidorSosic @ACSBioMed @fellerflix Thank you, Izidor. JESS in Action 😉

@FKH_Lab @ACSBioMed @fellerflix Congratultaions!

Kicking of the new year with our first publication: Our paper dealing with FEM1B-recruiting HDAC #PROTACs is online in #JMedChem @ACSBioMed. We noticed selective HDAC1-3 degradation. Congrats to Felix @fellerflix, Irina, Martina, Heiko, Svenja and Maria! pubs.acs.org/doi/10.1021/ac…

The application period for the second cohort of our RTG 2873 @grk2873 is open! We are now recruiting 12 PhD students. For more information see our homepage: grk2873.uni-bonn.de/en. My own project will focus on the development of HDAC #PROTACs. Please RT! grk2873.uni-bonn.de/en/training-pr…