
Alessandra de Souza
26.4K posts

Alessandra de Souza
@Farmale
PhD student - Fiocruz, MSc in Bioscience - UERJ. Pharmacist providing education and awarenes of IBD. Instagram: crohnscolitispharmale 🇺🇸 farmaleachou 🇧🇷









I have been asking for years: particularly in the US, with the financially motivated drive for early aggressive biologic Rx, how many #IBD patients are we over-treating and at what cost; (a) financial; (b) long-term outcomes and (c) AE/SAE-related? I find a lack of nuance in the field with insufficient discussion. So grateful for studies like this one. “In CD, by 10 years post-diagnosis, the probability of CD-related surgery decreased gradually but modestly with earlier initiation of biologics; a significant difference was noted between >2-3 years (31%) and 0-3 months (18%; P=.02, number needed to treat 7.7) while there was no difference between the 0-3 and >3-12-month periods… In UC, early introduction of biologics was not associated with reduced risk of colectomy or steroid-dependency.” #pediatricIBD #UC #Crohn’s doi.org/10.1053/j.gast…




























