Ferré Pascal retweetledi
Ferré Pascal
82 posts
Ferré Pascal
@FerrPascal2
Emeritus Professor, Sorbonne University Medical Faculty. Former Director Cordeliers Research Centre. Metabolic physiology. Liver metabolism. Type 2 diabetes
Katılım Kasım 2019
78 Takip Edilen89 Takipçiler
Ferré Pascal retweetledi
Ferré Pascal retweetledi
New in JBC press: "Scientists' study highlights for the first time that C2-ceramide (C2-cer) induces a loss in insulin sensitivity through the salvage/recycling pathway in muscle cells."
Learn more:
jbc.org/article/S0021-…
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Ferré Pascal retweetledi
Excited to publish our team's work in @jbiolchem which shows how ceramides can be recycled in muscle cells.
Ceramide analogue C2-cer induces a loss in insulin sensitivity in muscle cells through the salvage/recycling pathway pubmed.ncbi.nlm.nih.gov/37178918/
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@NatureRevEndo Very proud of our new review on Chrebp and NAFLD !
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New content online: The role of ChREBP in carbohydrate sensing and NAFLD development dlvr.it/SmRXbm
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@DanielJDrucker @PNASNews We published in 1989 a paper in the Biochemical J. (262, 881-886) showing in obese Zucker rat and using 2-DOG that the Hypoglycaemic effect of metformin results from an increased utilization of blood glucose by intestine. This was particularly true in hyperglycemic conditions.
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Finally, we know how #metformin works, in the gut to increase basolateral intestinal glucose uptake (BIGU) and via gut liver cross talk to reduce hepatic glucose production @PNASNews #diabetes pnas.org/doi/10.1073/pn…
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From Fabienne and Pascal to all our friends and colleagues…
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@StephenORahilly As we say in rugby to the defeated team: Good game lads!!
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No shame for Engiand. They were the better team for 60% of the game.
Carlos Ribeiro@RibeiroCarlitos
Will England Dutch this one?
Cambridge, England 🇬🇧 English
@StephenORahilly May I add the huges progresses made for treating the 400 millions diabetic subjects and diabetes complications such as cardiovascular diseases!!!
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Oh dear. Are you becoming a “what have the romans done for us?” Curmudgeon? I think people previously suffering terribly from diseases such asHep C, HIV, rheumatoid arthritis, IBD, a range of now curable cancers etc etc might have a different perspective on the “useful yield”
Paul Pharoah (R soul) 🇪🇺🇵🇬🇿🇦🇬🇧@paulpharoah
Given the climate disaster and the fairly low yield of useful output from biomedical science, should we pull the plug on the funding of most of the latter and vire it to research into the generation, storage and distribution of energy to replace fossil fuels?
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@StephenORahilly @IMS_MRL Oxford is a great memory. I spent two years there as a postdoc in Krebs lab working with D.H Williamson, a wonderful biochemist and man, with meetings bringing together H Krebs, D. Williamson, P Randle and sometimes E Newsholme, with R Turner around. What an amazing environment!
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Very much looking forward to going back to Oxford where I started doing diabetes research in 1984 with the wonderful and much missed Robert Turner. Honoured to be giving the Krebs lecture. Not something I ever thought I’d be doing way back then! @IMS_MRL
Medical Sciences@OxfordMedSci
Sir Stephen O’Rahilly will deliver ‘Some adventures in hormones, metabolism and behaviour' in honour of Sir Hans Krebs, who first discovered the ‘Krebs Cycle’. Thu 9 June, 4pm, Blakemore Lecture Theatre, Sherrington building: bit.ly/3OVIwlU. @UniofOxford members welcome
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@StephenORahilly Thanks Steve for your nice comment. The paper you mention got relatively unnoticed at the time but we were later glad to see that radiologists recommand to stop metformin for the detection of intestinal tumors by PET scan since it masks high glucose utilization by the tumor!
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So nice to see this photo! . Just yesterday I tweeted about the beautiful 1989 BJ paper from you Jean and Luc Penicaud on metformin action on the intestine. Such an important piece of work and really key to understanding how oral metformin actually works.
Ferré Pascal@FerrPascal2
Jean-Paul (right) and myself entered Jean Girard (left) ‘lab in 1975 and work with him for many years on metabolism during development. We have just celebrated our 80th and 70th birthdays together. Science can be such a humane and friendly adventure!
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Jean-Paul (right) and myself entered Jean Girard (left) ‘lab in 1975 and work with him for many years on metabolism during development. We have just celebrated our 80th and 70th birthdays together. Science can be such a humane and friendly adventure!
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A huge honour to receive this award that bears the name of such a distinguished scientist.@BiochemSoc @NEXSKU
Biochemical Society@BiochemSoc
Register now for this free webinar to hear from @proferikrichter at @uni_copenhagen the 2021 Sir Philip Randle Award winner. During this session he will present his Award winning research. Register now! #BiochemAwards attendee.gotowebinar.com/register/45207…
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Ferré Pascal retweetledi
Colleagues in academia and researchers, please don’t cry watching this
#AcademicTwitter #AcademicChatter #phdchat
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Ferré Pascal retweetledi
Open d’Australie : Monfils vient à bout de Kecmanovic et file en quarts de finale
➡️ l.leparisien.fr/1fyu
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