Igor Fesenko

Excited to share our publication on bacterial microproteome cell.com/molecular-cell… #microproteins #smORFs @storzlab

I started reviewing the paper and found this in the Introduction 😄

Happy to announce that our paper on orphan genes in bacteria dropped in PNAS yesterday! This is a problem I've been thinking about since the start of my PhD. Grateful for this journey, as well as All The Friends I Made Along the Way. Also, Eid Mubarak to those who celebrate!

New online! Emergence and evolution of protein-coding de novo genes dlvr.it/TQcswP

Fresh news on de novo genes! Happy to present our latest work published in Nature communications: nature.com/articles/s4146… Keywords not in specific order: intergenic ORFs, de novo genes, GC content, foldability, genetic code, ancestral sequence reconstruction and more :)

@meta_irony_ Orbitral Astral is a mass spectrometer 😄

@FesenkoIgor don’t know what it is, but love the name 😅something sci-fi

Our lab has finally received its New Year’s gift

I am happy to present our new paper on the de novo birth of microproteins in bacterial intergenic regions, conducted in collaboration with #storzlab. academic.oup.com/nar/article/53…

Our analysis indicates that bacterial pangenomes are largely closed, suggesting that the capacity of intergenic regions to generate de novo genes is limited.

We identified clear signatures of de novo origin for 4,838 microOGs. These smORFs often overlap with regulatory elements in intergenic regions, suggesting that translation-coupled regulatory mechanisms of gene expression may contribute to de novo microprotein emergence

@ReskiLab Happy Birthday, Ralf!🎂

The time has come

Latest from the lab: we’ve found that arbitrium phages can cross-communicate across species. Their molecular “language” isn’t as private as we thought. The original idea came from @AlbertoMarina14. As always, he was right. biorxiv.org/content/10.110…

Very happy to share our latest work “Systematic discovery and engineering of synthetic immune receptors in plants” out in @ScienceMagazine! science.org/doi/10.1126/sc…

😄

New Letter: "Large-scale pairing identifies a soybean phytocytokine-receptor module conferring disease resistance" rdcu.be/eBmrZ Scalable pipeline for systematic peptide–receptor discovery. In soybean, identification of a PEP914/890-P98R module in disease resistance.

Now online! A receptor antagonist counterbalances multiple systemin phytocytokines in tomato dlvr.it/TMcdxq

15th symposium on proteomics in the life science has started in Boston #ASBMB

🧬 How have tiny immune-signaling peptides evolved across the plant kingdom? Comparative analysis of small secreted peptide signaling during defense response: insights from vascular and non-vascular plants bit.ly/4eAUnmZ