学術変革A－予知生合成科学

2025年度の活動をまとめたニュースレターNo.4を発行しました！📰 #newsletter" target="_blank" rel="nofollow noopener">bio-4cast.skr.jp/activity/#news…

tRNA-Dependent Chemoenzymatic Transformation of Aminoacyl Pendant Moieties of Streptothricin Antibiotics | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/ja…

The Ozaki (A01), Uchiyama (A02), and Prof. Teigo Asai’s groups, in collaboration with Prof. Kuzuyama (A01) and Prof. Shinada (A03), characterized the unique terpene cyclase in vinigrol biosynthesis through mechanistic and theoretical analyses @J_A_C_S pubs.acs.org/doi/full/10.10…

The Shoji group (A03) reports a non-genetic strategy to activate native soil bacteria for aromatic pollutant degradation using decoy molecules that redirect cytochrome P450 activity, enabling degradation of benzene derivatives and chlorinated dioxin. doi.org/10.1039/D5TA09…

Hijacking tRNA chemistry to redesign antibiotics. The Maruyama group (A1), with the Ogasawara (A3) and Goto (A3) groups, uncovered a versatile enzyme generating new streptothricin derivatives and expanding antibiotic chemical diversity. @J_A_C_S doi.org/10.1021/jacs.6…

The Umemura group (A02), in collaboration with the Kuzuyama group (A01), reports a transformer-based platform that predicts and generates functional domains within biosynthetic gene clusters via unsupervised learning of domain organization in genomes. journals.plos.org/ploscompbiol/a…

Huge thanks to all who joined our conference at RIKEN (Wako, Saitama)! Truly inspiring talks and discussions. Looking forward to the next conference in July at Kitami Institute of Technology!

The Kuzuyama group (A01) reports the biosynthesis of the neuroprotective natural product kaitocephalin through genomic, enzymatic, and isotope-labeling analyses, laying the groundwork for elucidating its complete biosynthetic mechanism. onlinelibrary.wiley.com/doi/10.1002/an…

The Kato group (A03) reports a PCA-based database mining strategy to discover novel bacterial carbene transferases capable of stereodivergent cyclopropanation, highlighting a data-driven route to biocatalysts for abiotic transformations. doi.org/10.1002/anie.2…

The Nakano group (A02), in collaboration with the Chisuga group (A02), designed a high-fidelity sortase E with an activity trade-off. This enzyme can be applied to the synthesis of antibody conjugates. pubs.acs.org/doi/10.1021/ac…

The Katsuyama Group (A03) revelaed that ATP-dependent diazotase is involved in the biosynthesis of nitrous acid-dependent aromatic amination to produce 2,4-diamino-3-hydroxybenzoic acid. …mistry-europe.onlinelibrary.wiley.com/doi/10.1002/cb…

The Shoji group (A03), in collaboration with the Nakano group (A02), computationally redesigned the small heme protein HasA, achieving a +17.5 °C increase in thermostability while retaining metalloporphyrin binding, enabling robust HasA use. doi.org/10.1093/chemle…

The Katsuyama group (A03), in collaboration with Dr. Miyanaga at the University of Tokyo, published a review summarizing the use of protecting groups in natural product biosynthesis. pubs.acs.org/doi/10.1021/ac…

The Ogasawara group (A03) in collaboration with the Maruyama group (A01), revealed how three dehydratase domains precisely cooperate to introduce double bonds in DHA synthase, paving the way for future microbial production of valuable omega-3 fatty acids. doi.org/10.1002/ceur.2…

The Sato group (A01) demonstrated that genome mining of noncanonical class IB terpene synthases can expand the diversity of sesquarterpene (C35 terpene) skeletons and structures. pubs.acs.org/doi/full/10.10…

🎉 Our members presented at a symposium at #Pacifichem2025, sharing our research with the world 🌏

第七回公開シンポジウムの参加登録を開始しました！bio-4cast.skr.jp/251208-2/ 2026年2月13-14日に理化学研究所（和光市）鈴木梅太郎ホールで開催いたします。奮ってご参加ください！プログラムはこちら→bio-4cast.skr.jp/251119-2/

This work was featured as a journal cover in @Chem_CP !! cell.com/chem/issue?pii…

This work was selected by the Editor-in-Chief as a Highlighted Paper and featured on the back cover! jstage.jst.go.jp/article/cpb/73…

We had a wonderful 3rd Japan-Taiwan Symposium on Natural Products Biosynthesis held on Kaohsiung. Thank you all for the inspiring talks and stimulating discussions! Looking forward to seeing everyone again at the next symposium in Japan.