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@GPR109A

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Ned Buntline
Ned Buntline@BuntlineNed·
@OliLondonTV I’m missing something. With the pink and blue smoke fireworks… Was this building transgender…?
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Oli London
Oli London@OliLondonTV·
Mandarin Oriental Miami gets demolished with implosion. The iconic luxury hotel had operated in the building for over 20 years before being demolished in under 20 seconds. The site will be redeveloped into ‘The Residences at Mandarin Oriental.’
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HOM3OSTASIS.com@GPR109A·
@ianmiles You think Elon is “spreading lies about Wuute [white] genocide” in Africa So you think that it’s not happening— and that @elonmusk is a liar— yet you post this suckup review of him being a great boss Go fuck yourself This is you yesterday:
HOM3OSTASIS.com@GPR109A

@elonmusk Cheong is anti-white asshole & thinks whites being killed by groups of people & organized terror in Africa is cool— because you Mr. Musk— failed to mention every (rare) singular white-committed murder Ignore selfdefense & genocide & be ‘based’ like Ian x.com/gpr109a/status…

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Ian Miles Cheong
Ian Miles Cheong@ianmiles·
Marc Andreessen highlights why the people who work for Elon Musk echo the exact same sentiment as those who worked for Steve Jobs. Even after difficult interactions or a sudden departure, they inevitably report that they did the best work of their entire lives because they were pushed to their absolute limits. What drives this intense environment is a demand for truth-seeking at all costs. People who criticize Elon often miss this fundamental trait. He genuinely wants to know the ground truth and has zero tolerance for anything else. When confronting bad news, he is absolutely ruthless and relentless in making sure he understands exactly what is actually going on. This level of radical transparency is shockingly rare in the business world. The typical startup founder operates on forced optimism, constantly putting on a brave face, telling everyone to have faith, and promising that everything will be great just to keep talent from leaving. Elon completely flips that standard script. He operates with pure urgency by simply telling the unfiltered truth, even when that truth is that the company will go bankrupt and die if they fail. In almost any other corporate environment, that level of blunt, existential dread would cause the talent pool to immediately bleed out. But for the teams working under him, that brutal honesty acts as the ultimate catalyst. It strips away the corporate fluff and forces them to rise to the occasion, leaving them with the undeniable realization that, much like the engineers who built the first iPhone, they just completed the greatest work of their careers.
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Elon Musk
Elon Musk@elonmusk·
It has been such an honor to work with so many amazingly talented people
Ian Miles Cheong@ianmiles

Marc Andreessen highlights why the people who work for Elon Musk echo the exact same sentiment as those who worked for Steve Jobs. Even after difficult interactions or a sudden departure, they inevitably report that they did the best work of their entire lives because they were pushed to their absolute limits. What drives this intense environment is a demand for truth-seeking at all costs. People who criticize Elon often miss this fundamental trait. He genuinely wants to know the ground truth and has zero tolerance for anything else. When confronting bad news, he is absolutely ruthless and relentless in making sure he understands exactly what is actually going on. This level of radical transparency is shockingly rare in the business world. The typical startup founder operates on forced optimism, constantly putting on a brave face, telling everyone to have faith, and promising that everything will be great just to keep talent from leaving. Elon completely flips that standard script. He operates with pure urgency by simply telling the unfiltered truth, even when that truth is that the company will go bankrupt and die if they fail. In almost any other corporate environment, that level of blunt, existential dread would cause the talent pool to immediately bleed out. But for the teams working under him, that brutal honesty acts as the ultimate catalyst. It strips away the corporate fluff and forces them to rise to the occasion, leaving them with the undeniable realization that, much like the engineers who built the first iPhone, they just completed the greatest work of their careers.

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HOM3OSTASIS.com@GPR109A·
@fanteziderya Gpr109a is the nicotinic acid receptor so these other options will actually interfere trying to essentially ‘trick’ the receptor and will not give any sort of pharmacological benefit just fyi
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HOM3OSTASIS.com@GPR109A·
Figure 1 Nicotinic acid promotes epidermal differentiation in photodamaged human skin. Tissue arrays of skin biopsy samples from a clinical study of the effects of myristyl nicotinate (MN) in human subjects with photodamaged skin [5] were stained for… journals.plos.org/plosone/articl…
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HOM3OSTASIS.com@GPR109A·
In normal human primary & immortalized keratinocytes,nicotinic acid receptors show plasma membrane localization & functional G(i)-mediated signaling. In contrast, in a SCC derived cell line, receptor protein shows diffuse cellular localization & receptors are nearly nonfunctional
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HOM3OSTASIS.com@GPR109A

Figure 1 Nicotinic acid promotes epidermal differentiation in photodamaged human skin. Tissue arrays of skin biopsy samples from a clinical study of the effects of myristyl nicotinate (MN) in human subjects with photodamaged skin [5] were stained for… journals.plos.org/plosone/articl…

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HOM3OSTASIS.com@GPR109A·
working receptor You can have a cell with overexpressed receptor genes but still have poor niacin responsiveness if the receptor protein is not actually present on the cell surface where niacin can bind it. t.me/TrustTheFlush/…
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HOM3OSTASIS.com@GPR109A·
…trafficking / localization / maturation of the receptor protein. So the receptors may be: stuck inside the cell misfolded improperly processed internalized too much or not inserted into the membrane correctly Why that matters This means: more mRNA does not equal more…
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HOM3OSTASIS.com
HOM3OSTASIS.com@GPR109A·
The peptide used to generate the antibody effectively competed the antibody signal, demonstrating antibody selectivity 3C Normal keratinocytes demonstrate functional G protein-coupled nicotinic acid receptor signaling through Gi whose function is diminished in skin cancer cells.
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