Svilen Georgiev

Expansion Microscopy Explained What is #ExpansionMicroscopy and how does it overcome the diffraction limit of light? Instead of improving the microscope, the tissue itself is physically expanded, increasing the distance between molecules so they can be imaged. Subscribe to our YouTube channel for exclusive content and in-depth discussions on cutting-edge science! Check out our latest episode for more on #connectomics and #brainresearch. linktr.ee/neurosciencebe…

Reconstructing the Brain - Technical Difficulty Why is reconstructing neural circuits so demanding? In electron microscopy-based (EM) connectomics, brain tissue must be preserved, stained, and sliced into thousands of ultrathin sections. These sections are then imaged and computationally reconstructed using automated segmentation, followed by extensive human proofreading. Dr. Sven Truckenbrodt discusses the technical bottlenecks in high-resolution #neuralcircuit reconstruction and why data processing remains one of the biggest challenges in #brainresearch. Subscribe to our YouTube channel for exclusive content and in-depth discussions on cutting-edge science! Check out our latest episode for more on #connectomics and #brainresearch. linktr.ee/neurosciencebe…

Why Connectomics Is Still Limited Why can’t we simply compare many complete connectomes? Current large-scale #connectomics datasets are rare “hero experiments”  often costing tens to hundreds of millions and requiring enormous computational reconstruction. Dr. Sven Truckenbrodt explains why cost, scalability, and the need for comparative datasets remain major limitations in modern #brainmapping. Subscribe to our YouTube channel for exclusive content and in-depth discussions on cutting-edge science! Check out our latest episode for more on #connectomics and #brainresearch. linktr.ee/neurosciencebe…

How Tiny Is a Synapse? How small is a synapse, and why does its nanoscale size make studying the brain so difficult? Synapses exist at the nanometer scale, pushing the limits of modern #neuroscience and #microscopy. In our new episode, Dr. Sven Truckenbrodt explains why synapse size matters for neuroscience and #connectomics. Subscribe to our YouTube channel for exclusive content and in-depth discussions on cutting-edge science! Check out our latest episode for more on #synapses and #brainresearch. linktr.ee/neurosciencebe…

Unnatural Amino Acids for Precise Protein Labeling In super-resolution microscopy, labeling is key: unnatural amino acids enable precise, site-specific fluorophore attachment. Watch the full episode to learn how advances in #microscopy are reshaping our understanding of cellular structure: youtu.be/8cXV9J5NJQQ Subscribe to our YouTube channel for exclusive content and in-depth discussions on cutting-edge science! linktr.ee/neurosciencebe… #ProteinLabeling #UnnaturalAminoAcids #SuperResolution #Microscopy

The presynapse is one of the brain’s most crowded and complex structures, pushing conventional microscopy to its limits. Prof. Sauer from @Uni_WUE explains how super-resolution methods reveal the nanoscale organization of synapses. Watch the full episode here: youtu.be/8cXV9J5NJQQ Subscribe to our YouTube channel for exclusive content and in-depth discussions on cutting-edge science! linktr.ee/neurosciencebe… #Neuroscience #Synapse #Presynapse #SuperResolution #Neuroimaging

Prof. Markus Sauer from @Uni_WUE explains the physical and chemical origins of #photobleaching; Repeated excitation drives #fluorescent dyes into reactive states where interactions with oxygen destroy their ability to emit light, which is a fundamental limitation in #fluorescence and super-resolution microscopy. Watch the full episode here: youtu.be/8cXV9J5NJQQ Subscribe to our YouTube channel for exclusive content and in-depth discussions on cutting-edge science! linktr.ee/neurosciencebe…

Single-Molecule Localization Microscopy Explained How can individual #molecules be imaged with nanometer precision? Prof. Sauer from @Uni_WUE breaks down the core idea behind single-molecule localization microscopy and why it made #superresolution imaging possible. Watch the full episode to see how modern #microscopy reveals the inner architecture of cells. youtu.be/8cXV9J5NJQQ Subscribe to our YouTube channel for exclusive content and in-depth discussions on cutting-edge science! linktr.ee/neurosciencebe… #SuperResolution #SciencePodcast

Can physical activity reduce the risk of Parkinson’s disease? Prof. Randy Schekman explains that growing evidence suggests #exercise supports brain resilience and influence pathways linked to #neurodegeneration. 🏃‍♂️ Nobel Prize Laureate Professor Randy Schekman discusses how lifestyle factors may shape #brainhealth and why this area offers cautious but real hope for Parkinson’s disease prevention. #ParkinsonsDisease #ExerciseAndBrain #BrainHealth #Neuroscience Watch the full episode here: youtu.be/G1FNf2LBPBo?si… Subscribe to our YouTube channel for exclusive content and in-depth discussions on cutting-edge science! linktr.ee/neurosciencebe…

Funding Science Without Micromanaging How does Sergey Brin support scientific research? Prof. Randy Schekman explains that Brin funds research without dictating how the money is spent, choosing instead to trust scientists to manage research decisions. Watch the full episode here: youtu.be/G1FNf2LBPBo?si… #Short #SergeyBrin #ScienceFunding #ParkinsonsDisease #Neuroscience #RandySchekman Subscribe to our YouTube channel for exclusive content and in-depth discussions on cutting-edge science! linktr.ee/neurosciencebe…

What Do We Know About Parkinson’s Disease? Prof. Randy Schekman, Nobel Prize Laureate in Physiology or Medicine, joins Neuroscience and Beyond to discuss why #ParkinsonsDisease is so challenging to understand and where current research is still falling short. Watch the full episode here: youtu.be/G1FNf2LBPBo?si… Subscribe to our YouTube channel for exclusive content and in-depth discussions on cutting-edge science! linktr.ee/neurosciencebe…    #Short #ParkinsonsDisease #Neurodegeneration #Neuroscience #BrainHealth #RandySchekman

Why Extracellular Vesicles Matter Why are #extracellularvesicles so important, and what information do they carry about our cells? Prof. Randy Schekman explains that these vesicles reflect the internal state of their cell of origin and can provide a powerful snapshot of what is happening inside the body, making them highly relevant for #diagnostics and #biomarkers. 🧠 Professor Randy Schekman, Nobel Prize Laureate in Physiology or Medicine, joins Neuroscience and Beyond to discuss why extracellular vesicles matter and what they truly reveal about #cellcommunication. #Short #ExtracellularVesicles #CellBiology #Neuroscience #Biomarkers #RandySchekman Watch the full episode here: youtu.be/G1FNf2LBPBo?si… Subscribe to our YouTube channel for exclusive content and in-depth discussions on cutting-edge science! linktr.ee/neurosciencebe…

How lucky am I to have the chance to talk to such a brilliant person, Prof. Randy Schekman!

How Alzheimer’s Progresses Inside the Brain Alzheimer’s can be understood as a relay race: amyloid → immune activation → metabolic stress → tau pathology. Each mechanism hands off to the next, shaping how the disease spreads across the brain over time. This perspective highlights why researchers study inflammation, metabolism, and protein aggregation together, rather than focusing on a single pathway. 🧠 Don’t miss our episode on the neurobiology of Alzheimer’s and the immune brain with Prof. Heneka from @uni_lu. Subscribe to our YouTube channel for exclusive content and in-depth discussions on cutting-edge science! Watch the full episode here: youtu.be/EI_l91M9DE4?si… Find us on social media: linktr.ee/neurosciencebe… #Research #Science #AlzheimersResearch #Neuroinflammation #Neurodegeneration #Alzheimers #Neurobiology

Identifying genes linked to a disease doesn’t automatically lead to a treatment. Prof. Heneka from @uni_lu notes that we’ve known the genetic drivers of hair loss for decades - yet there is still no generalised genetic therapy approach for it. The same principle applies to #Alzheimers: gene discoveries help us understand risk and mechanisms, but translating this knowledge into effective therapies is not always straightforward.  🧠 Don’t miss our episode on the neurobiology of Alzheimer’s and the immune brain with Prof. Heneka. Subscribe to our YouTube channel for exclusive content and in-depth discussions on cutting-edge science! Watch the full episode here: youtu.be/EI_l91M9DE4?si…
Find us on social media: linktr.ee/neurosciencebe… #Science #Research #AlzheimersResearch #genetics #biology

Is Personalized Alzheimer’s Disease Treatment Possible? Cancer medicine can be highly personalized, but Alzheimer’s isn’t there yet. Why? Prof. Heneka from @uni_lu explains the fundamental barrier: by the time #memory loss appears, the #hippocampus is already severely damaged, leaving scientists with no access to living brain tissue for personalized treatment. Still, advances in #genetics, risk variants, and massive datasets may open the door to individualized #prevention strategies in the future. Subscribe to our YouTube channel for exclusive content and in-depth discussions on cutting-edge science! Watch the full episode here: youtu.be/EI_l91M9DE4?si… Find us on social media: linktr.ee/neurosciencebe… #Neuroscience #Alzheimers #PersonalizedMedicine

Why Detecting Alzheimer’s Early Is So Hard Diagnosing Alzheimer’s once memory loss appears is relatively straightforward, but by then, the #disease has already advanced. In fact, the biological changes begin silently, years or even decades before symptoms emerge. Professor Michael Heneka from @uni_lu explains why spotting Alzheimer’s in these earliest, invisible stages is one of the field’s toughest challenges and why identifying people on the path long before they become “patients” remains so difficult. 🧠 In our latest episode, we explore the #biology of Alzheimer’s, #neuroinflammation, and the search for early #biomarkers. Subscribe to our YouTube channel for exclusive content and in-depth discussions on cutting-edge science! Watch the full episode here: youtu.be/EI_l91M9DE4?si…
Find us on social media: linktr.ee/neurosciencebe… #Neuroscience #Alzheimers #BrainHealth #AlzheimersAwareness #EarlyDetection #DementiaResearch

What Is Noise Beyond Decibels? Noise isn’t just about loudness; it’s also about distraction and overload. As Chris Berdik explains, even when sounds aren’t damagingly loud, they compete for our attention. 🎥 Watch Episode #30 with @chrisberdik to explore how #Noise shapes our #health, #focus, and #wellbeing in a noisy world. Neuroscience and Beyond: Episode Highlights We hosted Chris Berdik, science journalist and author of Clamor: How Noise Took Over the World and How We Can Take It Back, to discuss how noise impacts both the body and mind. He shared how chronic exposure affects sleep, stress, cognition, and even risks for dementia, and why creating healthier soundscapes in cities, workplaces, and schools is key to improving wellbeing for humans and wildlife alike. #Neuroscience #Health #UrbanDesign #SoundDesign #CognitiveScience #Wellbeing #ScienceCommunication Watch the full episode on this link: youtu.be/A5HZSU03qIM?si… Find us on social media: linktr.ee/neurosciencebe…

How the Amygdala Shapes Personal Space and Social Behavior Raymundo Báez-Mendoza, Ph.D., explains how damage to the #amygdala can distort our sense of personal space. Patients with bilateral amygdala lesions don’t feel discomfort when others get too close. It is a striking example of the amygdala’s key role in processing threat, emotion, and social distance! 🎥 Watch Episode #28 with Raymundo Báez-Mendoza to learn about #AmygdalaFunction, #SocialNeuroscience, #PrimateResearch, #GameTheory, #EmotionProcessing and more! Neuroscience and Beyond: Episode Highlights We hosted Raymundo Báez-Mendoza, Ph.D. @thunderNeurosci, neuroscientist and group leader at the German Primate Centre @DPZ_eu, to discuss how the brain governs social behavior. He explained how trust, cooperation, and social distance are represented in the brain, and how the amygdala contributes to emotional regulation and social understanding. Using insights from human and primate research, we talked about how neuroscience unravels the biology behind social decision-making. #Neuroscience #SocialBehavior #BrainFunction #CognitiveNeuroscience Watch the full episode on this link: youtu.be/AFb4pQJC9zo?si… Find us on social media: linktr.ee/neurosciencebe…

What Does Single-Cell RNA Sequencing Tell Us? Single-cell RNA sequencing offers a detailed snapshot of what each cell is doing at a given moment, revealing its genetic activity and potential protein functions. By analyzing transcriptomic data, researchers can predict how individual cells contribute to brain function and disease, even when RNA-protein correlations aren’t perfect. 🎥 Watch Episode #27 with Dr. Verena Haage to explore how #SingleCellRNASequencing, #Microglia, and #Transcriptomics are transforming our understanding of #brain health, #aging, and #disease. Neuroscience and Beyond: Episode Highlights We hosted Dr. Verena Haage, guest scientist at @ChariteBerlin and co-founder of @Sci_Lead, to discuss how cutting-edge tools like single-cell RNA sequencing are reshaping microglia research. She explained how these immune-like brain cells influence development, aging, and neurodegeneration, and highlighted the importance of linking molecular data with the exposome for a deeper understanding of brain health. #Neuroscience #BrainHealth #Neuroimmunology #Proteomics #Neurodegeneration #SciLead #WomenInScience Watch the full episode on this link: youtu.be/ZRQzm6BKyqo?si… Find us on social media: linktr.ee/neurosciencebe…