Svilen Georgiev

Such a wonderful conversation!

Building a Better Future for Science | Challenges in Academia with Prof. Tiago F. Outeiro Are we evaluating scientists in the wrong way? In this episode of Neuroscience and Beyond, Prof. Outeiro discusses some of the biggest problems in science today: 🔬 Too many researchers competing for too few positions 📉 Pressure to publish and overreliance on impact factors and citations 🤝 The need for more staff scientists, technicians, and long-term research roles — not only professors and PIs ⚖️ Work-life balance, burnout, and the changing culture of academia 🚀 How AI and new technologies may reshape scientific work Tiago also emphasizes that science needs more inclusive and sustainable career paths: “We need to work together from the top to the bottom, from the bottom to the top to try to change things.” What’s your biggest challenge in academia? Share your thoughts in the comments! 💬 Subscribe to our YouTube channel for exclusive content and honest conversations about academic life. 🔗 Link to the video: youtu.be/VP7uEhdIhng #Academia #Science #Research #PhD #Postdoc #Neuroscience #Parkinsons #Alzheimers #AcademicLife #Scientists #STEM #ResearchCulture #AI #Podcast #NeuroscienceAndBeyond

Aging and Neural Balance The brain operates under tight regulation of excitation and inhibition. Nicole Rust explains that this balance is essential for stable function, and aging may impair the mechanisms that maintain it. Subscribe to our YouTube channel for exclusive content and in-depth discussions on cutting-edge science! linktr.ee/neurosciencebe… #Aging #Neuroscience #BrainHealth #Homeostasis #Neurodegeneration

How to Measure Memory: Objective vs Subjective Memory can be tested with clear ground truth, you either saw an image before or you didn’t. Nicole Rust explains that this objectivity is crucial for studying the brain, and highlights why subjective states like mood, where only the individual has access, are much harder to measure and compare across species. Watch our latest episode to learn more about #Memory #BrainResearch and find us on other platforms: linktr.ee/neurosciencebe… #Neuroscience #CognitiveScience #Neurobiology

How Attention Shapes What You See Vision is not purely passive. Nicole Rust explains how attention links sensory input with task goals, comparing what you see with what you’re searching for. Watch our latest episode to learn more about #Attention #VisualProcessing and find us on other platforms: linktr.ee/neurosciencebe… #Neuroscience #CognitiveScience #Perception

From Pixels to Perception: Vision, Memory, Mood and Brain Disease Cures | Prof. Nicole Rust 🚨NEW EPISODE ALERT🚨 Your eyes don't see the world; your brain constructs it. But how, and what does it miss along the way? In this episode of Neuroscience and Beyond, we speak with Prof. Nicole Rust, Professor of Psychology at the University of Pennsylvania, whose research combines behavioural experiments, #neural recordings, and #computational models to understand how we see, remember, and experience the world. We explore how the brain transforms raw light into meaningful #perception, from the #retina through a hierarchy of visual areas all the way to object recognition in the inferotemporal cortex. We discuss how #attention shapes what enters #memory, why humans can recognise thousands of images seen only once, and why mood remains one of the hardest problems in neuroscience. The conversation also unpacks the central argument of her new book, Elusive Cures: that treating conditions like depression will require abandoning the "broken domino" model of disease and embracing the brain as a complex dynamical system. In this episode, you'll learn: - How the #brain transforms light into perception - Why attention acts as a filter and why we miss more than we think - How the brain stores thousands of images with striking detail after just a single viewing - Why we still cannot look at a brain and determine what #mood it's in - Why the "broken domino" model has held back treatments. Subscribe to our YouTube channel and follow us for exciting neuroscience content. 🔗Link to our social media accounts: linktr.ee/neurosciencebe… 🔗Link to the video: youtu.be/_aI_Nh_klw4 #Neuroscience #VisualNeuroscience #Memory #Perception #MoodNeuroscience #Depression #BrainHealth #ElusiveCures #ComplexSystems #BrainResearch #ScienceCommunication #BrainHealthMatters #NeuroscienceAndBeyond

Alpha-Synuclein in the Nucleus: New Insights #AlphaSynuclein isn’t just at the synapse it’s also found in the cell nucleus. While most of the protein remains presynaptic, its nuclear presence may reveal new mechanisms behind #ParkinsonsDisease and #LewyBody disorders, opening doors to fresh research questions. Watch the full episode to uncover what nuclear #AlphaSynuclein tells us about #ParkinsonsResearch. Subscribe to our YouTube channel for exclusive content and in-depth discussions on cutting-edge science! linktr.ee/neurosciencebe… #Neuroscience #BrainHealth #ProteinResearch #Neurodegeneration #CellBiology #ParkinsonsResearch

Exercise: Parkinson’s Disease Modifier Exercise is the most effective disease-modifying strategy we currently have for Parkinson's disease, shown to reduce risk and slow progression. Unlike a “magic pill,” it’s a powerful, evidence-based intervention available to everyone. Watch the full episode to learn how #Exercise can modify #ParkinsonsDisease risk and progression. #BrainHealth #Neuroscience Subscribe to our YouTube channel for exclusive content and in-depth discussions on cutting-edge science! linktr.ee/neurosciencebe…

How to address big scientific questions - Focused Research Organizations Why are some scientific problems too big for #academia but not yet suitable for industry? Traditional academic labs are small, often driven by individual PhD students or postdocs. At the same time, industry typically focuses on problems with clear commercial returns. This leaves a gap for large-scale, high-risk scientific challenges. Dr. Sven Truckenbrodt explains the concept of a Focused Research Organization, a philanthropically funded model that brings together 10–20 scientists to work intensively on one major problem. At E11 Bio, this approach is used to scale #connectomics by reducing costs and increasing speed.

Expansion Microscopy Explained What is #ExpansionMicroscopy and how does it overcome the diffraction limit of light? Instead of improving the microscope, the tissue itself is physically expanded, increasing the distance between molecules so they can be imaged. Subscribe to our YouTube channel for exclusive content and in-depth discussions on cutting-edge science! Check out our latest episode for more on #connectomics and #brainresearch. linktr.ee/neurosciencebe…

Reconstructing the Brain - Technical Difficulty Why is reconstructing neural circuits so demanding? In electron microscopy-based (EM) connectomics, brain tissue must be preserved, stained, and sliced into thousands of ultrathin sections. These sections are then imaged and computationally reconstructed using automated segmentation, followed by extensive human proofreading. Dr. Sven Truckenbrodt discusses the technical bottlenecks in high-resolution #neuralcircuit reconstruction and why data processing remains one of the biggest challenges in #brainresearch. Subscribe to our YouTube channel for exclusive content and in-depth discussions on cutting-edge science! Check out our latest episode for more on #connectomics and #brainresearch. linktr.ee/neurosciencebe…

Why Connectomics Is Still Limited Why can’t we simply compare many complete connectomes? Current large-scale #connectomics datasets are rare “hero experiments”  often costing tens to hundreds of millions and requiring enormous computational reconstruction. Dr. Sven Truckenbrodt explains why cost, scalability, and the need for comparative datasets remain major limitations in modern #brainmapping. Subscribe to our YouTube channel for exclusive content and in-depth discussions on cutting-edge science! Check out our latest episode for more on #connectomics and #brainresearch. linktr.ee/neurosciencebe…

How Tiny Is a Synapse? How small is a synapse, and why does its nanoscale size make studying the brain so difficult? Synapses exist at the nanometer scale, pushing the limits of modern #neuroscience and #microscopy. In our new episode, Dr. Sven Truckenbrodt explains why synapse size matters for neuroscience and #connectomics. Subscribe to our YouTube channel for exclusive content and in-depth discussions on cutting-edge science! Check out our latest episode for more on #synapses and #brainresearch. linktr.ee/neurosciencebe…

Unnatural Amino Acids for Precise Protein Labeling In super-resolution microscopy, labeling is key: unnatural amino acids enable precise, site-specific fluorophore attachment. Watch the full episode to learn how advances in #microscopy are reshaping our understanding of cellular structure: youtu.be/8cXV9J5NJQQ Subscribe to our YouTube channel for exclusive content and in-depth discussions on cutting-edge science! linktr.ee/neurosciencebe… #ProteinLabeling #UnnaturalAminoAcids #SuperResolution #Microscopy

The presynapse is one of the brain’s most crowded and complex structures, pushing conventional microscopy to its limits. Prof. Sauer from @Uni_WUE explains how super-resolution methods reveal the nanoscale organization of synapses. Watch the full episode here: youtu.be/8cXV9J5NJQQ Subscribe to our YouTube channel for exclusive content and in-depth discussions on cutting-edge science! linktr.ee/neurosciencebe… #Neuroscience #Synapse #Presynapse #SuperResolution #Neuroimaging

Prof. Markus Sauer from @Uni_WUE explains the physical and chemical origins of #photobleaching; Repeated excitation drives #fluorescent dyes into reactive states where interactions with oxygen destroy their ability to emit light, which is a fundamental limitation in #fluorescence and super-resolution microscopy. Watch the full episode here: youtu.be/8cXV9J5NJQQ Subscribe to our YouTube channel for exclusive content and in-depth discussions on cutting-edge science! linktr.ee/neurosciencebe…

Single-Molecule Localization Microscopy Explained How can individual #molecules be imaged with nanometer precision? Prof. Sauer from @Uni_WUE breaks down the core idea behind single-molecule localization microscopy and why it made #superresolution imaging possible. Watch the full episode to see how modern #microscopy reveals the inner architecture of cells. youtu.be/8cXV9J5NJQQ Subscribe to our YouTube channel for exclusive content and in-depth discussions on cutting-edge science! linktr.ee/neurosciencebe… #SuperResolution #SciencePodcast

Can physical activity reduce the risk of Parkinson’s disease? Prof. Randy Schekman explains that growing evidence suggests #exercise supports brain resilience and influence pathways linked to #neurodegeneration. 🏃‍♂️ Nobel Prize Laureate Professor Randy Schekman discusses how lifestyle factors may shape #brainhealth and why this area offers cautious but real hope for Parkinson’s disease prevention. #ParkinsonsDisease #ExerciseAndBrain #BrainHealth #Neuroscience Watch the full episode here: youtu.be/G1FNf2LBPBo?si… Subscribe to our YouTube channel for exclusive content and in-depth discussions on cutting-edge science! linktr.ee/neurosciencebe…

Funding Science Without Micromanaging How does Sergey Brin support scientific research? Prof. Randy Schekman explains that Brin funds research without dictating how the money is spent, choosing instead to trust scientists to manage research decisions. Watch the full episode here: youtu.be/G1FNf2LBPBo?si… #Short #SergeyBrin #ScienceFunding #ParkinsonsDisease #Neuroscience #RandySchekman Subscribe to our YouTube channel for exclusive content and in-depth discussions on cutting-edge science! linktr.ee/neurosciencebe…

What Do We Know About Parkinson’s Disease? Prof. Randy Schekman, Nobel Prize Laureate in Physiology or Medicine, joins Neuroscience and Beyond to discuss why #ParkinsonsDisease is so challenging to understand and where current research is still falling short. Watch the full episode here: youtu.be/G1FNf2LBPBo?si… Subscribe to our YouTube channel for exclusive content and in-depth discussions on cutting-edge science! linktr.ee/neurosciencebe…    #Short #ParkinsonsDisease #Neurodegeneration #Neuroscience #BrainHealth #RandySchekman