Greg Timblin

Updated preprint up - direct supplementation with the metabolic cofactor Coenzyme A reverses macrophage immunosuppression + promotes pro-inflammatory & anti-microbial macrophage phenotypes via positive influence on CoA-dependent glucose metabolism (1/x) biorxiv.org/content/10.110…

Beware of large AI models especially in biology and healthcare. They can make accurate predictions using all kinds of shortcuts & spurious reasoning. This is very important work.

It was a fun privilege to share a few thoughts on building biotechs with Nature Biotechnology for their 30th Anniversary issue - covering a broad range of topics including translating science into medicines, technology cycles, and financing biotech companies... nature.com/articles/s4158…

A corner stone of cell models: mRNA abundance scales with cell size & growth rate. Changes in growth rate shift many mRNA levels coordinately. Thus, the transcriptional responses to perturbations often reflect the associated growth rate changes. molbiolcell.org/doi/full/10.10…

Queso = Spanish for cheese Kasos = a Greek island K, so = a Midwestern woman explaining the situation

@nypost Bubble

I did the stomach-churning 999 Challenge at Citi Field - and it felt a lot like watching the Mets trib.al/aqAlnLh

The sycophantic behavior of artificial intelligence (AI) chatbots, which has been designed to increase user engagement, poses risks as people increasingly seek advice about interpersonal dilemmas. A new paper in Science measured the prevalence of social sycophancy across 11 leading large language models. The model’s responses were nearly 50% more sycophantic than humans’, even when users engaged in unethical, illegal, or harmful behaviors. If AI is designed to tell users what they want to hear instead of challenging their perspectives, then are such systems likely to motivate people to accept responsibility for their own contribution to conflicts and repair relationships? Even a single interaction with sycophantic AI reduced participants’ willingness to take responsibility and repair interpersonal conflicts, while increasing their own conviction that they were right. Yet despite distorting judgment, sycophantic models were trusted and preferred, incentivizing AI developers to preserve sycophancy despite the risks. science.org/doi/10.1126/sc…

@SickosCommittee It's there. Looooong and low frequency. Reminds me of something...like a line drive jump shot hitting a metal backboard in a schoolyard & it vibrating from the hit lol

Wait, was that an inaudible DOINK? Does the UFL not mic up the goal posts?

exactly why we need models that truly understand the physics of biomolecular interactions!

I trust what DL writes

" Large computational models do not understand (the physics and energetics of protein folding and compound binding) any more than LLM chatbots know what they are “saying” " science.org/content/blog-p…

@hrdevrythng @therealjuicyj 👀

Happy Birthday to Gary Ruvkun, Class of 1973 (Biophysics) and a native of Berkeley. A molecular biologist, Ruvkun was awarded the Nobel Prize in Medicine in 2024 for discovery of the role of microRNA in post-transcriptional gene regulation.

KAWHI’S 20-POINT STREAK: Kawhi Leonard can join an exclusive group tonight as the LA Clippers visit the Indiana Pacers (7pm/et, NBA League Pass). The seven-time All-Star enters with 49 consecutive 20-point games and can become the 14th player in NBA history to reach 50 – and the first to do so at age 30 or older. He is averaging 29.2 points during the streak, which began Nov. 28, 2025, and is the longest single-season run in Clippers franchise history.

I have a story up today about why young college grads are feeling so angry: It’s more than just rising unemployment and the threat of AI. It’s a deep sense of betrayal. 1/ nytimes.com/2026/03/27/bus…

Regulatory milestone! Novartis $NVS agrees to acquire Excellergy, Inc. to strengthen next-generation anti-IgE innovation in food allergy and immunology. This acquisition builds on leadership in IgE-driven diseases with Phase 1 asset Exl-111. @Novartis Link: novartis.com/news/media-rel… #Biotech #Pharma #M&A #Allergy

people who have never had their ass chewed & held accountable by a coach or loved one in their life & it shows 😭

"researchers found that nearly a dozen leading models were highly sycophantic, taking the users’ side in interpersonal conflicts 49% more often than humans did — even when the user described situations in which they broke the law, hurt someone or lied." nytimes.com/2026/03/26/wel…

LeBron is 41 moving like prime Shaq in this play

Hey man Cooper DeJean is cool & all… But MY GOD BEN MCCOLLUM CAN HOOP. He nice with it at 44😮‍💨

Trump admin coming after Stanford Med School, Ohio State and UCSD (NYTimes link in next message) Good luck to us. We're actively seeking non govt funding. I'm happy to make a pitch to anyone interested in funding open science in AI for genomics that has a history of impact. 1/