Genetics News

Identification of a novel base J binding protein complex involved in RNA polymerase II transcription termination in trypanosomes journals.plos.org/plosgenetics/a… #Trypanosoma #Genetics #openaccess #AfricanSleepingSickness

Aberrant cell segregation in the craniofacial primordium and the emergence of facial dysmorphology in craniofrontonasal syndrome journals.plos.org/plosgenetics/a… #Genetics #RareDisease #morphometry #development #OpenAccess

Genetic studies of urinary metabolites illuminate mechanisms of detoxification and excretion in humans nature.com/articles/s4158… #genetics #metabolism #kidneydisease #GWAS

Incremental data integration for tracking genotype-disease associations #genetics #mousemodels #diseaseresearch journals.plos.org/ploscompbiol/a…

Missed the @emblebi release? Check out our article on how IMPC researchers are using new categorisation systems to find new candidate genes associated with #raredisease. #genetics #data #mouseresearch mousephenotype.org/news/how-impc-…

The @impc has been 'shining a powerful light' on the dark genome. #darkgenome #genetics #raredisease

Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes #genetics #breastcancer #GWAS nature.com/articles/s4158…

FAM222A encodes a protein which accumulates in plaques in Alzheimer’s disease #genetics #mousemodels #Alzheimers nature.com/articles/s4146…

"This study would not have been possible without the IMPC" mousephenotype.org/blog/2019/10/0…

Gene Ontology Causal Activity Modeling (GO-CAM) moves beyond GO annotations to structured descriptions of biological functions and systems nature.com/articles/s4158… #genetics

Synergistic effects of common schizophrenia risk variants nature.com/articles/s4158… #genetics

Genetic behavioral screen identifies an orphan anti-opioid system science.sciencemag.org/content/365/64…

MNS1 variant associated with situs inversus and male infertility nature.com/articles/s4143… #genetics

Evaluation of methods to assign cell type labels to cell clusters from single-cell RNA-sequencing data rna-seqblog.com/evaluation-of-… #genetics

Today’s #GeneOfTheDay is #Got1. Human diseases associated with this gene include Atrial Fibrillation. Mice with this gene inactivated exhibit prolonged RR interval and decreased heart rate. More data here: bit.ly/Got1gene

Ultrarare variants drive substantial cis heritability of human gene expression nature.com/articles/s4158… #genetics

From a database of genomes to a forest of evolutionary trees nature.com/articles/s4158… #genetics

A reference genome for pea provides insight into legume genome evolution nature.com/articles/s4158… #genetics

Systematic characterization of BAF mutations provides insights into intracomplex synthetic lethalities in human cancers nature.com/articles/s4158… #genetics

Adaptation of host transmission cycle during Clostridium difficile speciation nature.com/articles/s4158… #genetics