Grigorios Georgolopoulos

Check out this article: Infant with rare, untreatable disease becomes first to successfully undergo personalized gene therapy - generegther.gr/en/information…

@Climate_Earth20 @COVID19_disease I drive around without a belt and I'm fine. Belts are overhyped

@COVID19_disease I live here and it's fine. Over hyped.

⚠️ BREAKING: Super Flu Spreads Across UK as Hospitals Lose Nearly 13,000 Beds to ‘Bed-Blocking’ Patients Schools battling flu outbreaks have closed; officials urge the sick to skip Christmas, MPs call for emergency vaccines.

@Sandbird_ Ω, δεν είδα φωτό 3 που γράφει για το σύνδρομο 😯

@GeorgolG Ναι αλλά τα drugs δεν προκαλούν Ramsay Hunt (ο VZV όμως ναι). Εκτός κι αν είναι 'ντραγκια' για καταστολή του ανοσοποιητικού (wink wink, τι άλλο προκαλεί εξασθένηση του ανοσοπ.?)

«Βρίσκεται σε κρίση. Είναι μανιακός, δεν κοιμάται, δεν τρώει σχεδόν καθόλου, και στέλνει αγχωμένα μηνύματα μέσα στη νύχτα», ανέφερε χαρακτηριστικά η πηγή. «Συχνά δεν έχει ειρμό στα λεγόμενά του, αλλά είναι πεπεισμένος πως όλα έχουν νόημα» 🤔 enikos.gr/lifestyle/tzas…

@Sandbird_ Μην είν' και τα ντρόγκια ξερωγω

🤔

Interested in single cell genomics but need help getting started? Check out the full agenda for our Single Cell Genomics Day on Friday 4/25. All talks will be live-streamed (no registration required) at satijalab.org/scgd25

⭐ Huge NEWS for the Human Cell Atlas! ⭐ The Human Cell Atlas signs a partnership with the UNESCO. @humancellatlas @UNESCO Tremendous recognition of the Human Cell Atlas (HCA) project's vision, ethical standards, and global impact. UNESCO, renowned worldwide for promoting open science, educational development, and ethical frameworks, now formally acknowledges the HCA’s efforts and mission. This collaboration honors HCA’s commitment to building a truly representative atlases of the global human population, underscoring our dedication to inclusivity, openness, and equity in scientific research. As we move forward into the next exciting phase, developing also disease-specific atlases, this partnership with the UNESCO will empower us to tackle significant global health challenges, including diseases endemic to regions and worldwide pandemics. Today, I'm feeling even prouder to be part of the HCA! 🧡 Looking forward to contributing further to building this remarkable effort in an inclusive, equitable, and truly global manner. humancellatlas.org/news/the-human…

Do non neuronal cells exhibit basic memory features? 🤯

@andygxzeng Wonderful resource! I'm just wondering how well the Mk trajectory is represented given megs are particularly tricky to isolate. Any insights?

Our tutorials teach you to map scRNA-seq data from normal and malignant blood samples within minutes. github.com/andygxzeng/Bon… Alternatives: I don't like Azimuth due to low HSPC resolution, but here are some other great atlases: doi.org/10.1038/s41590… doi.org/10.1038/s41590…

I’m excited to share an R package that we’ve created for mapping scRNA-seq data across normal and malignant hematopoiesis! We've used this to identify hematopoietic stem cells from healthy tissues and map leukemia cells from hundreds of patients. 1/6 github.com/andygxzeng/Bon…

🧵In new work, we report a systematic engineering roadmap to optimize large serine recombinases (LSRs) for direct, site-specific insertion into the human genome 🧬. We achieved over 50% insertion efficiency and 97% genome-wide specificity, a 10X improvement over our previous work

@arjunrajlab @Yifang17957864 @SRouhanifard This has been a pipe dream for so long! I still remember trying to make smartFlare work. What a waste of time and money that was.

This is so awesome!!! A long-standing dream for the field of single-cell transcriptional regulation. Congrats to @Yifang17957864, @SRouhanifard and team!

@daweonline Even the word itself broke 😮‍💨

*conda

That time of the year when a co da update breaks everything

Parallel molecular data storage by printing epigenetic bits on DNA nature.com/articles/s4158…

@trader280 @jueyun_chilis @hodgetwins Buying stocks is not the same as utilizing taxpayer money

@GeorgolG @jueyun_chilis @hodgetwins I would say NASA did but the shuttle wrecked them. As to the public, lots of them seem to be on board by buying stock.

Elon just turned science fiction into reality 🤯

@trader280 @jueyun_chilis @hodgetwins Of course no public agency would take such risk. It would immediately get defunct on the first incident. The public doesn't want to gamble with their money

@jueyun_chilis @hodgetwins Culture of fear after the shuttle disasters. Nobody wants to be the leader of the next disaster and they have seemingly pivoted away from new launch to more exploration and satellites which they do really well.

@m_osterwalder Congrats Marco! Beautiful work!

It's a great pleasure that our study about the regulatory role of the Shox2 gene desert – a non-coding genomic region with multiple critical functions in embryogenesis - is finally out! #unibern #UCalgary #BerkeleyLab nature.com/articles/s4146… #devbio #enhancers #Shox2 #GeneDeserts

These two trends are consistently seen for regulatory DNA. So keep this in mind before wasting time and compute on architecture engineering and huge foundation models. 3/3

Want to learn how transformers and large-language models can help to organize&understand single cell profiles? Led by @arturszalata, we review current such approaches in single cell genomics and give perspectives towards foundation models etc. nature.com/articles/s4159…

All compbiologists and wet-lab biologists working with compbio folks should print this & paste it on their doors and monitors. Too many folks think comp analysis is just a way to create pretty figs for a decorative ad for the data. Rigor is paramount. There should no compromise.

Delighted to share our latest work performed in close collaboration with the Nerlov lab. Hematopoietic stem cell heterogeneity and age-associated platelet bias are evolutionarily conserved | Science Immunology science.org/doi/10.1126/sc…

Wondering how many of the LTRs in the lentiviral vectors deposited are mangled