Giannone Lab

Excited to share our new paper "Actin-driven nanotopography promotes stable integrin adhesion formation in developing tissue". rdcu.be/dWie7 We study the single molecule dynamics of integrin adhesion proteins in developing Drosophila embryonic muscle attachment.

Congratulations and many thanks to Filipe Nunes Vicente @piponunesv, Tianchi Chen @leucine5030 and Olivier Rossier @olivier_rossier and to the @GiannoneLab

Here is a Share Link to our recent review @TrendsCellBio focusing on Novel imaging methods and force probes for molecular mechanobiology of cytoskeleton and adhesion. Nice to share beautiful studies from wonderful labs. authors.elsevier.com/a/1fg8M3QxxSnJ…

The @GiannoneLab and the Nassoy Lab have open positions for postdocs at the University of Bordeaux. The goal of the project is to understand at the molecular level integrin adhesions and actin protrusions in cancer cells migrating in 3D cellular assemblies: organoids, spheroids.

11/n - Our results thus indicate that forces exerted by elongation of individual actin filaments on WRC increase its turnover, operating as a mechanical negative feedback on Arp2/3 activation and thus cell migration.

10/n – WRC crosslinking, using the extracellular handle, reduces the ability of actin elongation forces to remove WRC from the lamellipodium tip, resulting in an increased WRC dwell time and higher Arp2/3 activity, enhanced polymerization and more effective migration.

Read the full article rdcu.be/cAOEm of our new study @NatureCellBio showing how forces generated by actin filaments regulate the WAVE complex to control new actin generation at the leading edge of migrating cells. Check out the following thread as a summary:

Check out the News&Views by Laura Machesky and Robert Insall (nature.com/articles/s4155…), related to our recent study @NatureCellBio showing how the WAVE complex is regulated by mechanical forces.

Here is the shared link to our recent article @NatureCellBio showing how forces generated by actin filament elongation regulate the WAVE complex during cell migration. Read here: rdcu.be/cAOEm

Please check out our recent study @NatureCellBio. Using single protein tracking and optical tweezers to show that actin elongation forces control actin regulator dynamics and functions at the leading edge of membrane protrusions during cell migration. nature.com/articles/s4155…