Giessen Lab

Nature has a trick to evolve multimeric proteins via gene duplication. 🧬One copy compensates, the other explores.🧬 Although this has only been a theory so far. Until now: Directed evolution of multimeric proteins by dual-compensatory gene duplication. biorxiv.org/content/10.648…

New paper out @NatureComms. Tremendous work by postdoc Mike Andreas, congrats! nature.com/articles/s4146…

New review out @ChemBioChem. Learn all about encapsulin shells! …mistry-europe.onlinelibrary.wiley.com/doi/full/10.10…

New paper out at @acsnano. Awesome work by PhD student Seokmu Kwon (@smkwon6) and postdoc Mike Andreas! pubs.acs.org/doi/abs/10.102…

Recent paper out at Protein Science (@ProteinSociety). Congrats to now graduated PhD student Robert Benisch (@robertbe_)! onlinelibrary.wiley.com/doi/full/10.10…

New preprint out @biorxivpreprint. Great work by PhD student Seokmu Kwon (@smkwon6) and postdoc Mike Andreas. Congrats! biorxiv.org/content/10.110…

New preprint out @biorxivpreprint. First two-component encapsulin system. Incredibly complex assembly. Congrats to PhD student Cassie Dutcher and postdoc Mike Andreas! biorxiv.org/content/10.110…

New preprint out @biorxivpreprint. First structure of a Family 2B encapsulin. Congrats to postdoc Mike Andreas! biorxiv.org/content/10.110…

New paper out @NatureComms. Congrats to postdoc Mike Andreas, great work! nature.com/articles/s4146…

New paper out @NatureComms. Congrats to postdocs Jesse Jones (now faculty at Idaho State) and Mike Andreas! nature.com/articles/s4146…

New publication from the lab. Congrats to PhD student @robertbe_ and postdoc Mike Andreas. Great work! science.org/doi/10.1126/sc…

Postdoctoral Research Fellow positions in cryo-EM | microbial biochemistry | protein engineering | natural product sciences available in our lab!

1/ We’re excited to share our work on HIV-1 trafficking by dynein! Led by the amazing @badieyan in the lab with wonderful collaborations with @EdcampbellLab, @GiessenLab, Aiken Lab, Böcking Lab, and @morgan_desantis. TL;DR HIV-1 hijacks the dynein motor protein for motility 🧵

Happy to have this paper published in @ACSSynBio doi.org/10.1021/acssyn… Congrats to my student @smkwon6

Come join our faculty @UMich in beautiful Ann Arbor! Learn more and apply at jobs.sciencecareers.org/job/615128

New preprint is out on @biorxivpreprint: biorxiv.org/content/10.110… We characterize a highly acid-stable and dynamic encapsulin nanocage exhibiting pH-dependent all 'open' or all 'closed' pore states. #encapsulin #nanocage

New preprint is out on @biorxivpreprint: biorxiv.org/content/10.110… We engineer novel nanocages to package RNA and protein in vivo at the same time for future drug co-delivery applications. Congrats to my student @smkwon6 #RNA #drugdelivery #encapsulin #nanocage

Thanks to @GiessenLab and Prof Schiller @FRIAS_UFreiburg for the external examination

Happy that our review on the structure, function, and basic biology of encapsulins is now available @AnnualReviews of Biochemistry: annualreviews.org/doi/10.1146/an… #encapsulin #nanocompartment #stressresistance #naturalproducts

Our study on pore structure and molecular flux into #encapsulin nanocompartments with @GiessenLab is now in shiny typeset format in @ScienceAdvances science.org/doi/10.1126/sc… Congrats @nurentasneem, Lachlan, Regi, @taylorszyszka and Eric @MyxXanthus from our lab, and... 🧵