Glut4Science

New carbohydrate intake recommendations for endurance sports. 🚴🏼‍♂️🎿🏃🏽‍♂️ Based on: - What science says about it 👨🏻‍💻 - Our field-research findings ✅ - What best athletes in the world currently do 🏆 - Our experience and everyday work with professional cyclists 🚴🏼‍♂️🚴🏼‍♂️ @MVAitor #carbs

Re-reading this paper from some years ago. I understand it better now! Worth reading. "In conclusion, our results support evidence that lactate regulates the glycolytic flux through modulating PFK due to its effects on the enzyme quaternary structure." portlandpress.com/biochemj/artic…

Lactate is known as a preferred fuel for the cell. But it’s also an important signaling molecule👇🏼 Can it help in muscle cell differentiation and hypertrophy, and result in better muscle regeneration?💪 📍Check this paper (interesting, not conclusive…): researchgate.net/publication/32…

One of my most valuable learnings that has shaped how I understand metabolism: 👉🏼 “Stress doesn’t always mean adaptation, although stress is a condition to adapt.” Applied to cellular level (⬆️PGC1α ≠ always ⬆️mito proteins) or organism level (⬆️training load ≠ ⬆️results).

1/3 Why do you feel weak when you’re sick (e.g., viral infection)? Why do muscles hurt? It is INSULIN RESISTANCE (acute). That’s how it feels like.🤯 Interesting, isn’t it? Sickness response activates pro-inflammatory cytokines that altere insulin signaling pathways. But why?

Lactate is a buffer agent, but not only on pH. 👉🏼 Lactate buffers CARBOHYDRATES in the body. 🛩️🆙 Lactate elevates up the travelling status of carbons: from traveling in Economy (glucose) to a privilege seat in Business (Lactate) 😜 Read this paper 👇🏼 pubmed.ncbi.nlm.nih.gov/38388706/

This is the reason why sometimes high carbohydrate interventions are not considered effective or adequate to the exercise purpose by athletes, practitioners or scientists.

Lactate cannot be understood without its specific transporters, MCTs. This paper shows how MCT1 (high affinity with lactate - involved in influx to the cell and mitochondria) impacts on the substrate shift and metabolic reprogramming. Worth reading: science.org/doi/10.1126/sc…

Things were serious today… 🥵🤯 Anyone guessing the reading on the Lactate Plus for the same sample? What’s the difference between Lactate Pro 2 and Lactate Plus monitors? Check this reference to begin with: pubmed.ncbi.nlm.nih.gov/39158591/

@Glut4Science 22- Is lactate buffer agent? Lactate always travels with an H+, meaning traveling in or out of the cell, through MCT1 or MCT4, it will always play a key role in regulating the overall pH of the body - intra and extracellular. It all depends on the fiber’s redox state!! 🤓🩸

Today’s paper on Lactate Metabolism. A good narrative review by Li, X. et al. “An indispensable substance for various physiological cellular functions, lactate plays a regulatory role in different aspects of energy metabolism and signal transduction.” nature.com/articles/s4139…

Thank you @tntsports for highlighting our work at Salomon. We keep improving as a team to help our athletes developing themselves as healthy and high performance individuals. tntsports.co.uk/trail-running/…

The paper of the day. If you really want to learn about Lactate and its role as regulator of genes expression, this is a good reference. mdpi.com/1422-0067/26/1…

Lactate is suggested to be neuroprotective after brain injury - better than ketones? - which might be a potential treatment, for example, in concussions after a crash - high speed sports like cycling, motorsports… This research studies it: link.springer.com/article/10.100…

Lactate fuels the brain and it triggers signaling processes such as angiogenesis, with important potential effects such as improved cognition. Beyond muscle and heart, nervous system is determined by lactate too, and this is pretty interesting (big!!). link.springer.com/article/10.118…

I did a post on Glut4science some years ago addressing the topic of glycogen storage in the brain. 👇🏼 How the brain regulates its energetic demands is something absolutely fascinating. I suggest reading about it.

When available, lactate is used preferentially by the brain thru its oxidative metabolism. Interestingly, this metabolic shift “saves” glucose that is afterwards used for “supporting/nom energetic” purposes (by astrocytes?). physoc.onlinelibrary.wiley.com/doi/10.1113/JP…

Is there a biomarker that can determine mitochondrial health and track mitochondrial alterations? Always a very hard and “unfair” question to answer, but in this paper 2 potential candidates are examined: GDF-15 😳 cf-mtDNA 🧬 Very interesting! biorxiv.org/content/10.110…

Hoy en El País, apnea para la mejora del rendimiento. Gracias Carlos.

Buccal health matters and high carbohydrate intake can be a factor that affects it negatively. What do we know about reducing that impact? - A hydrogel structure might be beneficial. - pH is probably the key factor. Sports nutrition industry has still some work to do!

Why is fructose so important in high carbohydrate fueling? You might think because of the absorption limit of glucose, but that’s only a bit. Its metabolic pathway is of big interest partly due to its lactate production (liver). Fructose is not only for 2:1 ratio, explore it!!