GonçaloCasteloBranco

Our latest in @NatureNeuro, lead by @mukundkabbe, providing single cell epigenomic maps of the human brain & spinal cord with snATAC and our NanoCUT&Tag and finding epigenetic memory in oligodendroglia of developmental programs! nature.com/articles/s4159… illustration by @Lilaeh

@AMVoronova @NatureNeuro @mukundkabbe @Lilaeh Thanks Anastasia!

@GoCasteloBranco @NatureNeuro @mukundkabbe @Lilaeh Congratulations!

Our latest in @NatureNeuro, lead by @mukundkabbe, providing single cell epigenomic maps of the human brain & spinal cord with snATAC and our NanoCUT&Tag and finding epigenetic memory in oligodendroglia of developmental programs! nature.com/articles/s4159… illustration by @Lilaeh

@kitazawa_taro @NatureNeuro @mukundkabbe @Lilaeh Thanks Taro!

@GoCasteloBranco @NatureNeuro @mukundkabbe @Lilaeh Congratz, Goncalo!

@RongFan8 @karolinskainst Thanks Rong!

Check out this beautiful work — an impressive data resource and super fascinating insights into the epigenetic memory of oligodendroglial development! Congratulations to @GoCasteloBranco and team at @karolinskainst 👏👏👏

@FdeCastroS @NatureNeuro @mukundkabbe @Lilaeh Thanks Fernando!

@GoCasteloBranco @NatureNeuro @mukundkabbe @Lilaeh 👏🏻👏🏻👏🏻🎩

@Di_0579 @NatureNeuro @mukundkabbe @Lilaeh Thanks Di!

@GoCasteloBranco @NatureNeuro @mukundkabbe @Lilaeh huge congratulations！

and my soundtrack for the last part of the ride, Lykke Li's Lucky Again youtu.be/6OO49j8nSZ8?si…

with @D_eck_ard, @CarlstromKarl @OzgeDumral @dvd_bruggen @mandy_meijer @LuiseASeeker and many others. Thanks @Cancerfonden @Hjarnfonden @KAWstiftelsen @ERC_Research @Vetenskapsradet etc for their support.

Check our latest preprint, Christoffer et al. at our lab developed KaroSpace, with which you can quickly generate a browser to explore your own or published spatial omics data! And here goes my soundtrack to spatial explorations, DJ-Kicks by Erlend Øye youtu.be/naKrdCozPUg?is…

Warm congratulations to The Brain Prize winners 2026, Professor David Ginty and Professor Patrik Ernfors, for their pioneering work on how the nervous system detects and processes touch and pain. @hhmi_science #Neuroscience #BrainPrize2026

New paper alert 🚀 Our organism-wide single-cell ATAC-seq atlas of mammalian aging is now out in @ScienceMagazine, led by our fantastic graduate student @ziyu__lu from @RockefellerUniv! science.org/doi/10.1126/sc…

The oligodendroglial map of the brain cell.com/cell/fulltext/…

How dopamine producing neurons arise in the developing brain – a new study from Karolinska Institutet. The findings could help improve how dopaminergic neurons are produced for transplantation in #Parkinson’s disease #research #neuroscience tinyurl.com/3ytnbpvh

This week, we report in @Nature our effort to identify molecular convergence and divergence in #autism spectrum disorder (ASD) using human stem cell models. In this collaborative study with Dan Geschwind's lab, spanning almost a decade, we derived 96 hiPS cell lines representing 8 genetic forms of ASD, idiopathic patients, and 20 controls, and after rigorous quality control differentiated 70 lines in more than 150 experiments into human cortical #organoids for 100 days. Interestingly, early time points harbored the largest mutation-specific changes, but distinct mutations converged on shared transcriptional changes as development progressed. This is just the beginning: we will need larger cohorts and more advanced cultures that capture cell diversity and interactions, such as #assembloids. Still, this initial study illustrates how risk associated with genetically defined forms of ASD can propagate through transcriptional regulation, leading to convergent and divergent signaling defects. This work was spearheaded by the heroic efforts of Aaron Gordon and Se-Jin Yoon, together with Lucy Bicks!

Molneuro curling kick off 2026 @karolinskainst!

Great team science across @YaleEngineering @YaleMed and @Penn, and truly excited about the future prospects in clinical pathology with @yalepathology ! 😊

Myelin is repaired by constitutive differentiation of oligodendrocyte progenitors | Science science.org/doi/10.1126/sc…

Registration for Single Cell Biology 2026 is now open! #SingleCell26 Join us as we explore new #SingleCell research insights and discoveries beyond the traditional model organisms🧬 🗓️ Dates: 10-12 June 📍 Wellcome Genome Campus, UK Bursaries 💰 📎 bit.ly/4pcfMHp

A fantastic week in Alicante discussing single-cell and spatial omics in the CNS! Thanks @FENSorg, all the speakers, students for lots of discussions, great talks and lots of fun in the social activities, the local organizers inc. @si_de_santis and co-chair Ana Falcão.

This week, the #FENS-Hertie #WinterSchool 2025-2026, “Single-Cell and Spatial Omics to Understand Brain Heterogeneity”, is taking place in Alicante, Spain. 🇪🇸 🧠 On Wednesday the day started with a session by Sara Bizzotto, and after a coffee break, participants enjoyed a talk by Özgun Gökce.