nancy gredig

One of the most jarring things about adulthood is the realization of how many truly incompetent people are in the most important jobs. When I was a kid, I just assumed everyone “important” was smart or they wouldn’t be important. Boy, was that fucking wrong.

Starting to think they've had it with us

In 2020, the world fell silent. Cities emptied. Borders closed. Families were separated. Millions of people found themselves alone, wondering when life would ever feel normal again. While much of the world searched for hope, one of Hollywood's most beloved actors quietly picked up his phone. Sam Neill wasn't promoting a movie. He wasn't chasing headlines. Instead, he walked out onto his farm in New Zealand and invited the world to spend a few peaceful minutes with him. He introduced everyone to Peggy the duck, who quickly became an internet favorite. Charlie Pickering waddled around the farm as if he owned the place. Helena Bonham Carter grazed peacefully in the fields, while Jeff Goldblum the ram and Michael Fassbender the rooster added their own unique personalities. There was even Bryce Dallas Howard, his rescue chicken, who became known as his loyal "guard chicken." The names made people laugh. The moments made them stay. There were no scripts. No expensive cameras. No carefully planned productions. Just Sam talking to his animals, reading poetry, sharing stories, singing the occasional song, and reminding millions that even during the darkest days, life could still be beautiful. For people trapped inside their homes, those simple videos became something to look forward to. A few minutes of calm. A few minutes of laughter. A few minutes where the world didn't feel quite so heavy. Years later, Sam Neill revealed that he had been diagnosed with stage 3 blood cancer. During treatment, he wrote his memoir and spoke openly about what mattered most. It wasn't fame. It wasn't awards. It was his family. His friends. His vineyard. His animals. And the simple privilege of waking up to another ordinary day. The man who spent decades helping audiences escape through unforgettable films ended up creating one of his most meaningful performances without ever stepping onto a movie set. He simply opened the gate to his farm, introduced the world to his animals, and reminded millions that hope doesn't always arrive with grand gestures

.@CBCPEI: Retired racehorses are living their best lives on P.E.I. thanks to this group @newstartstbsONT 🐎| CBC.ca share.google/nuQKR73H9CwgDA…

You know someone's crazy when you can watch the video on mute and it's still evident.

Why is Pierre dressed up as Homer in the episode where he’s Lurleen’s manager? 😆

@JOY365848654492 @DocPriyamMD What topical ones would you recommend?

As a nurse with 30+ years in US hospitals (med-surg, ICU & ER), I've seen this exact scenario more times than I can count. Young, healthy athletes or weekend warriors popping ibuprofen for soreness after intense runs, hikes, or even just a bad flu, then landing in the unit with crashing kidneys. Dr. Priyam, your thread is SPOT ON. NSAIDs + dehydration is a silent killer for the kidneys. Those prostaglandins are the kidneys' lifeline when blood volume drops. We used to drill this into patients and residents: hydrate aggressively first, and if you must use pain relief, reach for acetaminophen (unless liver issues). Topical NSAIDs can be a game-changer for muscle/joint pain with way less systemic risk. Thank you for breaking it down so clearly for the public. Lives get saved when awareness spreads like this. Stay hydrated out there, folks, especially if you're pushing your body hard! 💧🩺"

KIDNEY FAILURE at the age of 30. ​Runs half-marathons. Perfect diet. No smoking. No alcohol. ​But ONE common over-the-counter habit quietly suffocated his kidneys in a matter of days. ​A medical thread on what actually happened 👇

🚨 BREAKTHROUGH: The mRNA technology behind COVID vaccines has reached a historic milestone against cancer. A personalized mRNA vaccine reduced the risk of melanoma returning or causing death by nearly 50% over 5 years.🧵

Highway 413 threatens 29 species at risk. I went to see what Ford is willing to destroy. Tell Doug Ford to cancel Highway 413 now: gpo.ca/stop-highway-4…

@notoneseat Those people standing with him look so silly

Boo'ed at your own party is a special kind of humiliation. I love it so much.

Just say no to a Toronto island airport expansion - public consultation closes July 24 ✍🏼tc.canada.ca/en/corporate-s…

@afshineemrani Thank you for this so much

I'm a cardiologist. I prescribe cholesterol-lowering drugs every single day. They save lives. That science is settled and I will never tell you otherwise. But I'm going to say something that will make a lot of my colleagues uncomfortable — because someone needs to say it, and your doctor probably won't. Too many physicians make you feel crazy when you bring up statin side effects. You walk into your appointment and say "my muscles ache constantly" — and you're told it's in your head. You say "I'm exhausted all the time" — and you're told it's your age. You say "my sex drive disappeared" — and you get an awkward silence followed by a subject change. You say "I don't feel like myself anymore" — and you're told the benefits outweigh the risks, take the pill, stop reading the internet. I've watched it happen in my own field for twenty years. The conversation gets shut down. The patient gets dismissed. And then they do the one thing we should be most afraid of — they stop the medication entirely, without telling us, and lose the cardiovascular protection that's keeping them alive. That is the real cost of not being honest. Not the side effects themselves — the silence that drives patients away from treatment. In my practice, I see statin-related complications in at least 25% of my patients. Muscle pain. Fatigue that doesn't resolve with sleep. Reduced sexual drive. Brain fog. Cramping. Joint stiffness. Weakness that makes exercise — the very thing we tell them to do — feel impossible. Some of these improve with CoQ10 supplementation and optimizing vitamin D. Many do not. I wrote about the diabetes risk of statins in a New York Times op-ed in 2012. The backlash from the cardiology establishment was immediate. I was told I was undermining trust in a life-saving drug class. Fourteen years later, every major guideline acknowledges the risk I warned about. It's in the prescribing information. The physicians who attacked me for saying it now teach it to their residents. The truth doesn't care about professional comfort. It never has. Now a paper published this week in Science Advances has finally explained the mechanism behind statin myopathy — and the finding validates what millions of patients have been telling their doctors for years. Researchers discovered that statins activate the NLRP3 inflammasome in muscle cells — triggering an inflammatory cascade that causes muscle cell death, activates atrophy pathways, and disrupts muscle metabolism. This is entirely independent of the drug's cholesterol-lowering effect. The muscle damage isn't caused by lowering cholesterol. It's caused by a completely separate pharmacological action through a different pathway. The critical implication: the side effect can potentially be separated from the benefit. Blocking NLRP3 or restoring isoprenoids prevented muscle cell death without interfering with cholesterol reduction. Future therapies could preserve the cardiovascular protection while eliminating the muscle toxicity. Even more striking — the researchers found that background systemic inflammation significantly lowered the statin dose needed to trigger muscle damage. Patients with chronic inflammation, gut dysbiosis, or metabolic syndrome may be experiencing myopathy at doses their doctors consider "too low to cause problems." They're not imagining it. Their inflammatory state is priming the pathway. The muscle pain was never in their heads. It was in their NLRP3 inflammasome. And we finally have the molecular proof. Here's what I actually do in my practice — because I refuse to choose between protecting the heart and respecting the patient. Whenever possible, I avoid statins as my first-line approach for eligible patients by using alternatives that lower LDL through entirely different mechanisms with no muscle toxicity: PCSK9 inhibitors — Repatha and Praluent. Injections every 2-4 weeks that dramatically lower LDL without touching muscle tissue. No myopathy. No fatigue. No brain fog. For patients who can access them, these are transformative. Inclisiran — Leqvio. An siRNA injection I administer twice a year in my office. It silences the PCSK9 gene in the liver. Two shots a year. LDL drops roughly 50%. No muscle side effects. No daily pills. Now approved as first-line monotherapy. This is the future of lipid management and I use it aggressively. When statins ARE clinically necessary — and sometimes they are, especially post-heart attack or in combination therapy — I choose hydrophilic statins like rosuvastatin or pravastatin. These do not easily cross the blood-brain barrier. The cognitive complaints — the fog, the memory issues, the feeling of "not being yourself" — are substantially less common with these formulations because the drug stays out of the central nervous system. I never prescribe a statin without CoQ10. 100-300mg daily. Statins deplete the cellular energy molecule your muscles and heart depend on. Replenishing it reduces muscle symptoms in many patients. It should be standard practice. The fact that it isn't is a failure of our field. I check vitamin D and optimize it aggressively. Low vitamin D — which is epidemic — worsens muscle symptoms independently and compounds whatever the statin is doing. Target 50-80 ng/mL, not the bare minimum of 30. Bempedoic acid — Nexletol — for patients who can't tolerate any statin. Works upstream in the cholesterol pathway and is not active in muscle tissue. Specifically designed to avoid myopathy. Ezetimibe added to a lower statin dose. Cut the statin intensity, add ezetimibe to maintain the LDL reduction, and halve the muscle exposure. There is no excuse in 2026 for telling a patient "just deal with the muscle pain." The toolbox is deep. The alternatives exist. The only barrier is a physician's willingness to listen and adapt. I want to speak directly to every patient who has been dismissed. Your muscle pain is real. Your fatigue is real. Your cognitive changes are real. Your loss of drive — in every sense of the word — is real. A paper in Science Advances just proved the mechanism. You were never crazy. You were experiencing a documented inflammatory response in your muscle tissue that your doctor didn't have the science to explain — until this week. And I want to speak directly to my colleagues. We have to be honest. Not just about the benefits — which are enormous and undeniable — but about the side effects, the mechanism, and the alternatives. Patients who feel heard stay on treatment. Patients who feel dismissed stop their medications in silence — and die from the heart attacks we could have prevented if we'd simply been willing to have an honest conversation and switch the approach. The cardiologist who tells you statins are flawless is not protecting you. The wellness influencer who tells you statins are poison is not protecting you either. The truth lives in the middle — where it always has. Statins save lives. The side effects are real. The mechanism is now proven. The alternatives exist. And you deserve a doctor who holds all four of those truths at the same time. Both things can be true. They always could. Now we have the science to prove it.

A brand new bridge between Detroit and Canada is finished and ready to open. It would speed up traffic for millions of trucks, cut delays for American businesses, and help the auto industry that employs people in every state. There is just one problem. Donald Trump won’t let it open. Here is why. The family that owns the old bridge stands to lose business when the new one opens. So in January, they gave one million dollars to a pro-Trump super PAC. Weeks later they met with Trump’s Commerce Secretary. He called Trump. Hours after that, Trump announced he would block the new bridge. The opening was set for June 12. It got canceled the day before. The bridge sits there finished and empty. Now here is the part that should make every taxpayer angry. Canada paid for the entire bridge. Every dollar. And the United States already owns half of it for free. Trump is holding up a bridge we got for nothing, to protect a donor who wrote him a check, while picking a fight with our closest ally and biggest trading partner. This is corruption in plain sight. A billionaire pays, and the President delivers. American workers and businesses pay the price. Open the bridge. A government should work for the people, not for whoever writes the biggest check. nytimes.com/2026/02/20/us/…

@jphicks @DougWahl1 Fuuuuuuck

@DougWahl1 Fuck.

@HuffPost Fuuuuuck

“He went last night to enjoy a sport he loves,” a rep for the comedian told HuffPost after Cheryl Hines published the photo. huffpost.com/entry/comedian…

@SenatorCrossing @RachelBitecofer Good lord

Whoever engineered the Gingrich lady's hairdo should build Trump's Iron Dome for America.

@doubleplayball Ya but what a class act, I remember he apologized to me, a groom, for having to mush my filly a bit to win a trillium.

How about the burger combo from the hitching post. The crusty Greek always giving me attitude because of the extra pickles. Told him to hold a couple of fries. Rule number one back in the day: eat before going in. Stevie Condren could stiff for months to get one across.

@doubleplayball All the seagulls, the smell of old straw in the backstretch and all the bettors standing along the fence yelling at the drivers.

Sitting outside where Greenwood Raceway used to be and just a flood of memories. Man what a time that was and what a place. Million characters, roast beef on the second floor, horses everywhere and just the nice warm breeze hitting you as you watch the action.

Baby GOLDEN TEMPO cuando estaba al pie de su madre CARRUMBA