Greg Duncan

nature.com/articles/s4146… I am excited to announce our work on how myelin loss culminates in neurodegeneration has been published at Nature Communications. While I have previously covered our findings as a preprint in more detail below, our key findings are:

New work from Yasmine Kamen shows that differentiating oligodendrocytes are filled with the zymogen procaspase-3. This provides a specific marker for new oligodendrocytes and suggests a role for this pathway in oligodendrocyte fate decisions. biorxiv.org/content/10.110…

Our work was recently covered by the National MS Society if you are looking for a more lay summary of the results and its implications. nationalmssociety.org/news-and-magaz…

nature.com/articles/s4146… I am excited to announce our work on how myelin loss culminates in neurodegeneration has been published at Nature Communications. While I have previously covered our findings as a preprint in more detail below, our key findings are:

And the completion of this story was only possible because of all the help from the most amazing @Anya_A_Kim and Björn Neumann in the Franklin lab!🥰

@schirmerlab @MyelinLab Thanks Lucas!

@GregDuncs @MyelinLab Congrats!

@Jiaxingli Thanks Jiaxing!

@GregDuncs Congrats! Great work!

@Dr_Oligo Appreciated Wendy!

@LabStratton Thanks Jo!

@GregDuncs Nice work Greg!!

@EthanHughesLab Thanks Ethan! It's exciting to finally see it out!

@GregDuncs Congratulations Greg! Great to see this out

@Craigurs Thanks Craig! It's great to see it finally out.

@AJ_Thompson_ Thanks Andrew!

@GregDuncs Awesome! Congrats Greg!

3. Remyelination suppresses activation of DLK in neurons and safeguards them from degeneration. In conclusion, demyelinated neurons can be protected either by promoting remyelination or blocking neuronal DLK signaling. Thanks to all the coauthors who made this work possible!

1. Loss of demyelinated neurons in the retina requires activation of neuronal injury signaling mediated by the axonally-expressed protein Dual Leucine zipper Kinase (DLK). 2. DLK knockout or inhibitors protect neurons from degeneration.

@Jiaxingli @MonkLab1 @VollumInstitute @CathyFlyMom @ChristophWCowan Congratulations Jiaxing!

Can't wait for this new adventure in Charleston! Many thanks to @MonkLab1, @VollumInstitute, @CathyFlyMom, @ChristophWCowan and many others along the way!

@asghariadib @CathyFlyMom @ManishKD_neuro @abbby_rogers Congratulations Elham! It’s really great work.

My PhD work is now published 😍🥰 There are no words to describe how I feel right now. Thanks everyone for the hard work and dedication. @CathyFlyMom @ManishKD_neuro @abbby_rogers cell.com/cell-reports/f…

This has been the culmination of many years of work from myself and the coauthors of this manuscript, without which this work would have been impossible. Thank you all so much for your help!

What does all this mean? We can protect demyelinated neurons from loss in two ways – by promoting remyelination or by inhibiting DLK. Notably, even a relatively small degree of remyelination reduces apoptosis.

Very excited to share our preprint on how chronic myelin loss (demyelination) injures neurons and how we may be able to mitigate neurodegeneration in demyelinating diseases like MS biorxiv.org/content/10.110… Check out the thread 👇 for more details.