Lea Haarup Gregersen

68 posts

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Lea Haarup Gregersen

Lea Haarup Gregersen

@GregersenLab

Group leader at @UCPH_health, working on RNA-binding proteins and co-transcriptional regulation. Previously at @UPCH_BRIC, @BIMSB_MDC and @TheCrick

Katılım Kasım 2020
231 Takip Edilen425 Takipçiler
Lea Haarup Gregersen
Lea Haarup Gregersen@GregersenLab·
What is the function of the RNAPII-interacting SCAF proteins? In our latest work, led by Smaragda Kompocholi, we show that SCAF1 shapes mRNA isoform expression during neuronal differentiation 🧬🧠 Loss of SCAF1 → shorter mRNA transcripts biorxiv.org/content/10.648…
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Lea Haarup Gregersen
Lea Haarup Gregersen@GregersenLab·
Thank you to everyone involved and support from colleagues at Center for Gene Expression (CGEN), @UCPH_health!
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Lea Haarup Gregersen
Lea Haarup Gregersen@GregersenLab·
What happens to transcription upon oxidative DNA damage? 🧬💥 RNAPII halts instantly within genes ⛔️ and even more surprisingly: It restarts from where it stopped without leaving the DNA template 🚦 👀 How? Find out in our new preprint👇 biorxiv.org/cgi/content/sh…
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Lea Haarup Gregersen
Lea Haarup Gregersen@GregersenLab·
Key takeaways: 🔍Oxidative damage causes shutdown of transcription, without RNAPII degradation 🔍Stalled RNAPII resumes transcription from within the gene body 🔍PARylation controls early elongation restart 🔍BER and SSBR repair enable RNAPII recovery in the gene body
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Lea Haarup Gregersen
Lea Haarup Gregersen@GregersenLab·
This beautiful work, led by Quentin Thomas, revealed a surprising spatial organization of the transcriptional response: • Promoter regions: PARylation governs early RNAPII release • Gene body: DNA damage and repair drive RNAPII stalling
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Lea Haarup Gregersen
Lea Haarup Gregersen@GregersenLab·
Huge thanks to our amazing team and members with CGEN for fruitful discussions 🙌
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Lea Haarup Gregersen
Lea Haarup Gregersen@GregersenLab·
What did we find? ✅ Elongation rates vary between genes ✅…and within genes ✅ Histone marks & elongation factors correlate with rate subclasses
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Lea Haarup Gregersen
Lea Haarup Gregersen@GregersenLab·
The computational pipeline independently applies to existing DRB/TTchem-seq datasets - so you can improve the number of genes with single gene elongation rates from existing data, simply by using the new computational pipeline
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Lea Haarup Gregersen
Lea Haarup Gregersen@GregersenLab·
Existing methods either rely on indirect estimates or are limited to a handful of long genes. So we built DRB/TTchem-seq2: Short timepoint sampling, new computational framework 📈 leading to a ~7 fold increased individual gene elongation rates measurements!
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Lea Haarup Gregersen
Lea Haarup Gregersen@GregersenLab·
❗️One more week to apply for a PhD position in our group! Come join our team of transcription enthusiasts in Copenhagen👩‍🔬👨‍🔬
Lea Haarup Gregersen@GregersenLab

We are recruiting! Center for Gene Expression has 2 or more open positions for PhDs @uni_copenhagen. Come join our team to work on RNAPII and transcriptional regulation (gregersenlab.com) Great city and amazing research environment. Deadline March 6 jobportal.ku.dk/phd/?show=1634…

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Lea Haarup Gregersen retweetledi
Thomas Miller
Thomas Miller@TCR_Miller·
Looking for a #postdoc or #PhD in eukaryotic #DNA replication and #CryoEM? We are recruiting! The positions are fully-funded by the @novonordiskfond and come with access to cutting-edge facilities and fantastic colleagues in #Copenhagen. See links below for more information.
Thomas Miller tweet media
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@UCPH_health @JZylicz @liu_haiyue @uni_copenhagen @novonordiskfond @elonmusk @BarackObama @taylorswift13