Sebastian Greiss

Check out our Breakthrough Article in @NAR_Open where we use a quadruplet codon to expand the genetic code of an animal. @EdinburghUni @CDBSEdinburgh @SynthSysEd @ERC_Research #Celegans academic.oup.com/nar/advance-ar…

Check out our new paper for site-specific labeling proteins and building defined Ub/Ubl-protein conjugates using a plant Asp-endopeptidase. Great effort by @MaxFottner @jhmgrtnr @MaxGantz_ @RaMue1304 and @NkTimon! Congratulations to all!👩‍🔬👨‍🔬🤩🙌🥳

Generation of Photocaged Nanobodies for Intracellular Applications in an Animal Using Genetic Code Expansion and Computationally Guided Protein Engineering (Greiss) @GreissLab, @jack_oshea97 #openaccess onlinelibrary.wiley.com/doi/10.1002/cb…

1/7 Try our new app for optimizing transgenes for C. elegans expression (wormbuilder.org/transgenebuild…). The app uses algorithms from collaborators Henrik Bringmann (TU Dresden) and Dan Dickinson (UT Austin) - or codons from highly expressed ubiquitous genes.

1/5 Our paper is out as a bioRxiv preprint. @sonia_elmouridi and @FaisalMAlkhaldi Like MosSCI, just better. Targeted single-copy and array integration synthesizing new and gradual improvements from the past 15 years across many labs. biorxiv.org/content/early/…

Come and join us @Wallace_Lab @SBSatEd for your PhD in #biotechnology, investigating the use of #microbes to produce industrial chemicals from sustainable feedstocks and waste with @LubrizolCorp. Fully-funded studentship to start Oct '22 @SynthSysEd findaphd.com/phds/project/a…

Now in its final format and online as a hot paper 🔥😀 A great collaboration with the @SieberLab to profile the substrate scope of hClpP via genetic code expansion, photocrosslinking and proteomics! Congrats Anh, Thomas, Timon and everyone involved!! 🙌

The Funding Elves have been good to @Wallace_Lab in December 🎁 We'll be advertising for 5 PDRAs (1 with @JoSadler10) and 1 fully-funded PhD at the start of 2022. DM or email me with a cover letter and CV if you're interested in joining us @SBSatEd @SynthSysEd 🧫🧬🧪

Then we use the quadruplet to incorporate photocaged cysteine into a caspase for light induced ablation of C. elegans neurons.

We use photocaged lysine to express photocaged Cre recombinase for optical control of gene expression. Here the UAGA quadruplet works as efficiently as a UAG triplet.

Check out our Breakthrough Article in @NAR_Open where we use a quadruplet codon to expand the genetic code of an animal. @EdinburghUni @CDBSEdinburgh @SynthSysEd @ERC_Research #Celegans academic.oup.com/nar/advance-ar…

Interdisciplinary EASTBIO PhD project available on drug resistance and human fungal pathogens combining #Calbicans, #Celegans, and #Bioinformatics @Makrantoni_lab @r0bah0lic @EdinburghUni Only few days left to apply!! Deadline Dec 15. findaphd.com/phds/project/e…

PhD studies? Come join us! @EdinUni_MeetCIR @EdinUni_IRR. gramhansenlab.com/join-us/ 🔬🧫🧪🧬

Check out the early view of our new article in @angew_chem! A fantastic collaboration with the @SieberLab to profile the substrate scope of mitochondrial caseinolytic protease P via site-specific photocrosslinking 🧪💡🧫🧑‍🔬🧑‍💼 Congrats to Anh and Thomas! 🙌 onlinelibrary.wiley.com/doi/10.1002/an…

Excited to share this new preprint! We optimized a directed evolution strategy to engineer E. coli tyrosyl-tRNA synthetase for genetically encoding new unnatural amino acids in mammalian cells, including a nonhydrolyzable phosphotyrosine mimic biorxiv.org/content/10.110…

Interested in drug resistance and human fungal pathogens? Apply for our interdisciplinary EASTBIO PhD project to join us at @UoE_IM. Co-supervisors @Doitsidou_lab @r0bah0lic. Fully-funded, international applicants. Please RT! #Calbicans #Celegans findaphd.com/phds/project/e…

Playing Lego with ubiquitin: 🧱🧪🧬 Building complex Ub/Ubl chains using orthogonal sortases. Great work led by @MaxFottner 👏 with help from @mariaweyh and Dominic! Many thanks to Stefan and @Michael13120606 for the NMR-collaboration! 🥳🥂@ERC_Research nature.com/articles/s4146…

Check out our recent work with @lehorsfall on the use of microbial Pd nanoparticles and membrane-bound micelles for chemical synthesis. Microbes are amazing chemists! @SynthSysEd @SBSatEd @EdinburghChem pubs.rsc.org/en/content/art…

Our paper on improved genetic code expansion and using a laser to control gene expression in C.elegans is out. Congrats to lab members Lloyd Davis @aggelikigoutou @AilishTynan Kieran Baxter, Zhiyan Xi @jack_oshea97 @EdinburghUni @CDBSEdinburgh @SynthSysEd elifesciences.org/articles/67075