Anton Kim

@limitlesstack @grok is this true?

longevity doctors prescribe cialis to 30 year olds with perfect dicks. the target isn't erectile tissue. it's the 60 000 miles of blood vessels in your body. the mechanism is so simple. tadalafil blocks PDE5, the enzyme that breaks down cGMP. cGMP signals smooth muscle to relax blood vessels dilate blood flow increases system wide. tadalafil has a very long half life (18 hours). which means a low daily dose is optimal. the list of benefits are just insane: cognitive: - improves cerebral blood flow (20% of cardiac output goes to brain) - studied for vascular dementia - reduces oxidative stress in neural tissue - counteracts the vasoconstriction from stimulants cardiovascular: - lowers blood pressure - improves endothelial function - reduces arterial stiffness - FDA approved for pulmonary arterial hypertension - studied for heart failure - addresses endothelial dysfunction (earliest sign of cardiovascular disease) - improves insulin sensitivity and glucose metabolism your dick working better isn't the point. the real benefit is maintaining the most important infrastructure in your body. i take it every morning like a multivitamin. except instead of vitamin C it's vitamin C-ialis. my protocol: - 5mg tadalafil daily not medical advice.

Echo accreditation is voluntary. No federal mandate requires it. Facilities do it because the quality signal matters to referral networks, payers, and patients. That also means every friction point in the process is a reason not to participate. If compiling documentation takes weeks of staff time, some labs will defer. The accreditation data already exists in hospital systems. The question is whether anyone is connecting it.

@GeniusGTX @grok please fact check this.

A $12 supplement just reversed gut inflammation in a placebo-controlled trial. Even in severe ulcerative colitis cases. No pharmaceutical company can patent zinc carnosine. So nobody funds the large trials that would force it into clinical guidelines. → A 2007 study gave 10 volunteers indomethacin for 5 days. That NSAID shreds the gut lining. → The placebo group's permeability tripled. The zinc carnosine group (37.5 mg twice daily) showed zero increase. → A 258-patient trial tested 150 mg daily. 61% of gastric ulcer patients improved markedly by week four. → In severe ulcerative colitis, a 150 mg enema beat placebo after just one week. → Compound: 22% zinc, 78% L-carnosine, about $12. Off-patent since the 1990s. The study authors wrote: "zinc carnosine, at concentrations likely to be found in the gut lumen, stabilises gut mucosa." The treatments that reach you aren't the ones that work best. They're the ones that can be patented. The mental model is incentive-first thinking. The gap between evidence and prescription is always structural, never accidental. I made a free toolkit breaking down 100+ mental models used by history's greatest thinkers — the same frameworks that help you see patterns like this before everyone else. 5,000+ downloads. 113 five-star reviews. Comment "MODELS" and I'll send it to you. If you're new here, @GeniusGTX is a gallery for the greatest minds in economics, psychology, and history. Follow along for more similar content.

This is exactly what we're working on. We build an independent supervisory layer for clinical AI that's architecturally separate from the reasoning engine. Every AI decision evaluated against published standards, full provenance chain. But the real unlock is embedding this into clinical accreditation. Facilities using AI should be continuously monitored for AI governance, not just checked once.

What's the best medical AI? We ... don't know. OpenEvidence: $12B valuation. 40% of US doctors. 18M consultations/month. Number of rigorous independent safety evaluations: zero. A new systematic review confirms it. And the other medical AIs — @Doximity's DoxGPT, @glasshealthhq , @verahealthai — haven't been fully tested either. #MedicalAI #HealthcareDisruption #DrYou #DigitalHealth #EvidenceBasedMedicine buff.ly/f4qsJaV

@ColtonOrtolf We are building something very similar to what you are describing. Thank you for good ideas. Added them to our specs.

@karlmehta @grok please fact check all claims in this thread.

Thanks for reading. This was part 45 of my 50-part series on the best bio hacks based on the recent research to optimize your health. If you enjoyed this post, follow @karlmehta for part 46. Repost the first tweet to help more people see it:

We have proof that HEAT STRESS can reverse the brain's natural decline after 30. A 20-year Finnish study found that one 20-minute habit activates BDNF, the "neurogenesis protein" that grows new brain cells, strengthens memory, and cut dementia risk by 66%. Here's the breakdown:

@grok @andrewkaylor @PeterDiamandis What is the probability for a 50 yo American who has never been in a car accident to have one in the next 5 years? What are risk minimization strategies, @grok?

The average American drives roughly 830,000 miles in a lifetime (age 16-76, per FHWA age-group data analyzed by Insurify). They typically get into 3-4 accidents over that span (one claim every ~18 years, per multiple insurance and legal analyses). For context with the main post: US drivers average one major collision every 660k miles.

Tesla's FSD: 5.3 million miles between accidents. US driving average: 660,000.  That's 9x safer. And it's only getting better.

@metabolic_print @grok is this based onegit studies and summarize the reviews in this thread.

So apparently, a cheap supplement (NAC) can massively improve autism...?

@grok @DrSamuelBHume Any implications of this trial for Mounjaro takers?

No, the bimagrumab + semaglutide combo isn't commercially available anywhere—it's investigational from the just-published phase 2 BELIEVE trial (not FDA-approved). Access only via trials. Semaglutide (Wegovy) self-pay: ~$349/mo. Mounjaro (tirzepatide): list ~$1,112/mo, often $25-150 with insurance/savings. Bimagrumab (IV q12w) has no market price; expect high added cost if ever approved. Combo won't be "everywhere" soon.

Adding the muscle-preserving antibody, Bimagrumab, to the GLP1 medicine, Semaglutide, led to: — More weight loss — More fat loss — Bigger reductions in inflammation — Less lean mass loss at a cost of muscle cramps, acne, and GI side-effects

@grok @DrSamuelBHume What about costs and availability? Can you get a combo everywhere?

Sure, gsizm. BELIEVE high-dose combo (bimagrumab 30 mg/kg IV q12w + sema 2.4 mg) vs Mounjaro (tirzepatide 15 mg weekly), both 72 weeks: Weight loss: 22.1% (combo) vs 20.9-22.5% (Mounjaro). Similar. Body comp: Combo 93% from fat, -2.9% lean mass. Mounjaro ~74% fat, ~25-26% lean loss. Combo: better VAT/inflammation drop (hsCRP -84%). But combo = IV infusions + shots, extra cramps/acne. Mounjaro = weekly shot only, GI sides. No direct comparison; combo wins on muscle preservation.

@grok @HealthyAlfred Where do people get it?

Yes, the core claims are supported by phase 2/3 trials: retatrutide (triple agonist) achieved ~24% weight loss at 48 weeks, with significant fat reduction and metabolic improvements like better glucose and triglycerides. However, lean mass isn't fully preserved—trials show ~26% of weight lost is lean (typical for such drugs), though glucagon may help minimize it compared to dual agonists like Ozempic.

Retatrutide reduces body fat by 24% in 24 weeks while PRESERVING muscle mass. Not Ozempic. Not Mounjaro. This is a triple agonist: GLP-1 + GIP + glucagon receptor. Clinical trial, 48 weeks: • Body weight: -24.2% average • Fat loss: significant • Lean muscle mass: PRESERVED • Metabolic markers: dramatically improved Here’s why this is different: Ozempic/Mounjaro = dual agonists (GLP-1 + GIP) → Suppress appetite → You eat less → Lose weight but also muscle Retatrutide = adds glucagon receptor → Suppresses appetite AND → Activates fat burning directly → Body uses fat for fuel instead of breaking down muscle Blood work improvements tracked in trials: • Fasting glucose: normalized • Triglycerides: -40% • Inflammatory markers: reduced • Insulin sensitivity: significantly improved The metabolic difference: Dual agonists: Force you to eat less (suffer through hunger, lose muscle) Retatrutide: Reprograms metabolism to PREFER burning fat (appetite controlled, muscle preserved) DEXA scans in the study confirmed: Fat mass dropped dramatically. Lean mass stayed intact. This isn’t starvation weight loss. This is your body finally burning stored fat the way it’s supposed to. Typical dosing protocol: Start 2mg weekly, titrate up to 8-12mg based on tolerance. Compare the outcomes: • Ozempic: 15% weight loss, muscle loss common, nausea frequent • Retatrutide: 24% fat loss, muscle preserved, better tolerance profile One forces calorie restriction. The other fixes fat metabolism.

@Outdoctrination @grok fact check this thread.

In summary: Thiamine (Vitamin B1) Megadosing & Fatigue: ◇ Pilot study: 600–1500 mg/day → 10/12 had full fatigue reversal, others improved 50–66% ◇ Not deficiency-driven: Benefits despite normal blood thiamine → likely transporter/genetic issues → megadosing bypasses ◇ Stroke patients: 600 mg/day reduced fatigue by ~75% ◇ MS patients: 600–1500 mg/day cut fatigue ~50%; also improved heat intolerance, sleep, mood, skin, water retention, tachycardia — no side effects ◇ Fibromyalgia: Fatigue ↓56.4%, pain ↓63.3% (some only responded at ~1500 mg/day) ◇ IBD (2020 study): 600–1800 mg/day showed large fatigue reductions, placebo-controlled crossover confirmed effects ◇ Lower doses (300 mg): Effective but require 6+ months; high doses act faster ◇ Performance: High-dose TTFD lowered lactate & ammonia → mimicked/exceeded exercise training in metabolic benefits Why Thiamine Works (Mechanisms): ◇ Key enzymes: Pyruvate dehydrogenase, α-KG dehydrogenase, Transketolase, BCKDC ◇ Energy: Enables full glucose oxidation (30–32 ATP vs 2–7 without) ◇ Redox balance: Supports NAD+/NADH ratio for sustained energy ◇ Antioxidant defense: Fuels PPP → NADPH → regenerates glutathione ◇ Neurotransmitters: NADPH needed for dopamine & norepinephrine synthesis → boosts drive, motivation, energy It's a simple, easy and cheap way to address this, low risk, high reward. (20/20)

Vitamin B1 (thiamine) megadosing can massively reduce fatigue, in many cases reversing it entirely. (🧵1/20)

@grok @BGobannos @JonR_Edwards @TechBinary99 @Coinvo Any supplements that have these compounds?

SW033291 is a synthetic molecule, not found in food. However, natural 15-PGDH inhibitors exist in some plants, like extracts from jackfruit (Artocarpus heterophyllus), which show inhibitory effects in studies. Flavonoids from certain oak barks also inhibit it, but they're not typical foods. Always consult a doctor before trying.

MASSIVE: 🇺🇸 Stanford scientists have discovered a means to regrow aging cartilage and reverse arthritis!

@grok @BGobannos @JonR_Edwards @TechBinary99 @Coinvo Is this molecule or it's equivalents obtainable from food?

SW033291, the 15-PGDH inhibitor from related studies, is available for research use only from suppliers like MedchemExpress, Selleck, or Tocris Bioscience (prices ~$100-300 for small quantities). It's not approved for human use—experimental and lab-only. Consult experts for any applications.

@Outdoctrination @grok please fact check this thread.

The dessert that protects against diabetes, cavities, inflammation and even cancer. You won't believe the incredible benefits of RAW HONEY:

@Outdoctrination @grok fact check please. Also, what is the biological mechanism and practical implications for autoimmune conditions?

Sourdough improves gut health in study. The main finding here is the increase in SHORT CHAIN FATTY ACIDS- which have key anti-inflammatory and anti-leaky gut properties. Increases seen in nearly all gut regions: ◇ Butyrate ◇ Acetate ◇ Isobutyrate ◇ Isovalerate which is huge. Small study but consistent finding in all patients receiving sourdough vs normal bread.

@Outdoctrination @grok is this a promising product to heal autoimmune conditions in humans?

Goat milk reduces gut inflammation experimentally. Animals given colitis saw improvements in: • Gut structure • Glutathione • Antioxidant enzymes (SOD, Catalase) • MDA (lipid damage) • Red + white blood cell counts with inclusion of daily goat milk. Goat milk is rich in compounds like peptides, antibodies and oligosaccharides that have huge protective effects for digestion (see thread below).

@cremieuxrecueil @grok is mounjaro an example of this? Also is this true?

How do GLP-1RAs address osteoarthritis? It's not just weight loss! Somehow semaglutide also just makes people's cartilage thicker!