GuangLin He

Genomic convergence in hibernating mammals elucidates the genetics of metabolic regulation in the hypothalamus | Science science.org/doi/10.1126/sc…

Genome-wide genealogies reveal deep admixtures forming modern humans biorxiv.org/content/10.648…

A new study supports the hypothesis that Denisovan ancestry in Southeast Asian populations resulted from three distinct admixture events with three different Denisovan populations biorxiv.org/content/10.648…

Patterns of population structure and genetic variation within the Saudi Arabian population biorxiv.org/content/10.110…

The genetic legacy of archaic hominins in Central and Southeast Asia uncovers three distinct Denisovan populations biorxiv.org/content/10.648…

I have met archaeologists who are quite critical of ancient DNA and not very receptive to its potential contributions. I don’t share this sentiment. I think ancient DNA is the best thing that happened to archaeology.

@joe_pickrell The 3.7kb deletion can be reliably detected using Oxford Nanopore. An analysis of 61 healthy Middle Eastern individuals sequenced using ONT identified the deletion in 18 individuals. medrxiv.org/content/10.648…

@DinaMMoshrefi @gm_enah @christiandhuber DIna Congratulates

I'm delighted to share that my first PhD paper is now out in Nature Genetics! "Insights into human adaptation from ancient DNA" can now be accessed here: nature.com/articles/s4158… Many thanks for @christiandhuber's support! #AncientDNA #Genomics #EvolutionaryBiology #HumanHealth

Very interesting and rich work by @hrushikesh_loya @leo_speidel @simon_r_myers and others has many interesting findings. I want to highlight this figure, which is similar to the model David recently proposed. Can’t wait to read it more deeply

Online now: Six key trade-offs in ecological security pattern: reply to Harmange et al. dlvr.it/TS52WG

A human monoclonal antibody neutralizes SARS-CoV-2 Omicron variants by targeting the upstream region of spike protein HR2 motif Read more on hLife👇👇👇 doi.org/10.1016/j.hlif…

In a 2025 Science study, researchers introduced GAIA, a statistical approach that seeks to learn the geographic position of every genetic ancestor of individuals included in a genome dataset. Learn more in this #SciencePerspective: scim.ag/3QczrKR #ScienceMagArchives

hLife | Call for Papers: Human Genomics for Health We warmly invite researchers and clinicians worldwide to contribute original research, reviews, and case studies to help propel this transformative field forward. @WangChuanchao @GuanglinH

New preprint by Alison Baron and @aliakbari23 on selection in East Asia. Taking the method from Ali’s selection scan in West Eurasia and applying it to the Eastern half of the supercontinent reveals 40 variants with extremely high confidence (>99%) of being under selection

Complex peopling history and expansion events inferred from large-scale modern and ancient Y chromosome sequences | Science Advances science.org/doi/10.1126/sc…

A high-coverage Neandertal genome from the Altai Mountains reveals population structure among Neandertals | PNAS pnas.org/doi/10.1073/pn…

New solo paper from David Reich might provide some clarity to the Muddle in the Middle. Maybe Humans and Neanderthals are both hybrids of an old expansion of the "MSA population" and local European / African humans:

Introgressed mitochondrial fragments from archaic hominins alter nuclear genome function in modern humans | Science Advances science.org/doi/10.1126/sc…

Ancient genomes provide insight into the Paleolithic-to-Neolithic transition in northern East Asia: Current Biology cell.com/current-biolog…