Molecular Instruments

Submissions are still open for the HCR™ Image Contest: Best-In-Suit. From whole-mount Xenopus embryos to FFPE cancer tissue sections, we can’t wait to see your stunning images with HCR™ Gold and HCR™ Pro. 🏆 Winners will be featured in and receive our limited-edition deck of cards! 📥 Submit your entry here: lnkd.in/gyBws_yY

New Webinar: Spatial Mapping of Kidney Development and Disease Mechanisms in Xenopus laevis How do genetic variants disrupt kidney development and contribute to congenital kidney diseases? Join us on April 1 at 8:00 AM PT / 10:00 AM CT for a webinar with @rkmille and Adrian Romero Mora from @UTHealthHouston to learn how the Miller Lab uses Xenopus laevis as a vertebrate model to study nephron development in the embryonic kidney. #withHCR, the team visualizes gene expression and maps transcripts to specific nephron segments, helping uncover the mechanisms behind kidney development and disease. Register here: my.demio.com/ref/2ZwGxz9PLn…

We had a fantastic time at @neurocrine yesterday, connecting with the broader team and showcasing the latest HCR™ technology and its translational research applications. The session highlighted several exciting advances, including HCR™ Pro RNA-ISH workflows compatible with major autostaining platforms, along with our new fully ambient-temperature protocol; HCR™ Gold IF for multiplex protein detection, including simultaneous detection for same-species primary antibodies; and our latest capabilities for short-target detection. A big thank you to Robert Johnson for helping coordinate the event. We had a great time and look forward to continuing the conversation!

Best-In-Suit: Show us your best #HCRimages! There’s still time to submit your standout HCR™ Gold or HCR™ Pro images to our HCR™ Image Contest! Whether it’s extreme sensitivity, exceptional signal-to-background, or a beautiful field of view, we’d love to see what you’re capturing with #HCRtechnology. 🏆Best-in-Suit winners will be featured in and receive our limited-edition deck of cards, celebrating both the imagery and the science behind it. 📥 Submit your entry here: hcrimaging.typeform.com/image-contest

Uncovering Neurogenesis in the Gecko Brain 🧠 A recent study from Sara Jiménez Álvarez and her colleagues from @PhyloBrain brings high-resolution molecular readouts to a compelling non-model organism, the gecko Paroedura picta. Using #HCRtechnology, the team mapped gene expression in the embryonic gecko brain, enabling clear mRNA visualization in a system where species-specific antibody options can be limited. The researchers also paired HCR™ RNA-FISH with immunohistochemistry to connect RNA patterns with protein-level context during neurogenesis, expanding what’s possible in evolutionary and comparative neurobiology. Explore the full manuscript here: link.springer.com/protocol/10.10…

@labonnelab @Dev_journal Congratulations on being on the cover! The images look stunning!

We used @hcrimaging to reveal interesting new features of #neuralcrest development in #xenopus - Thanks to @Dev_journal for featuring it on the cover! And on #fluorescentfriday! journals.biologists.com/dev/article/15…

✨ Show us your best #HCRimages! ✨ Have a stunning HCR™ Gold or HCR™ Pro image? We’d love to see it! We’re collecting standout images for our HCR™ Image Contest, and selected “Best-in-Suit” winners will be featured in a limited-edition deck of cards celebrating the visual power of the HCR™ platform and the research behind it. If you’ve captured exceptional signal, clarity, or creativity, send it our way. We can’t wait to spotlight the incredible work coming out of the HCR™ community! 📥 Submit your entry here: hcrimaging.typeform.com/image-contest

Last week, we brought the HCR™ User Symposium to Boston and had the chance to connect with so many members of the HCR™ community in person. Thank you to everyone who joined us and helped make the day so engaging! A special thank you to our speakers: Nipam Patel (Marine Biological Laboratory), Jong Gwan Lee (Harvard Medical School), David Brann (Harvard Medical School), Henry Bushnell (Harvard Medical School), Evan Ratzan (Boston Children's Hospital), Daniel Winkowski (Visiopharm), and Maciej Zerkowski (Indica Labs). Their expertise and thoughtful presentations made for a truly impactful program. The range of HCR™ applications was incredible, from whole-mount fruit fly, butterfly, and beetle embryos all the way to mouse and chicken tissue sections (and more!). We hope the conversations throughout the day sparked new ideas and collaborations that continue well beyond the symposium. Looking forward to keeping the momentum going and sharing more ways to connect soon!

HCR™ Pro RNA-ISH just got more flexible! Manual HCR™ Pro workflows are now compatible across all X1 to X10 systems. With this update, you can pair HCR™ HiFi Probes you know and trust with manual HCR™ Pro, delivering high sensitivity and robust signal-to-background performance for challenging, low-abundance targets. 🔬 New to manual HCR™ Pro? Get started with a complimentary Starter Kit: lnkd.in/gsYapMnA

Today’s the last day to secure a spot and join us in Boston for the HCR™ User Symposium! ✔️Bring a colleague! All attendees will receive a complimentary HCR™ HiFi Probe for any target of their choice ✔️Networking opportunity with the broader HCR™ community ✔️Free to attend with a provided lunch RSVP today: hcrimaging.typeform.com/to/qAGFCv2L

HCR™ User Symposium | Speaker Spotlight Indica Labs is coming to Boston for the HCR™ User Symposium! On February 19, you’re invited to a live, hands-on session with Maciej Zerkowski, featuring a walkthrough of Indica Labs’ HALO software and a deep dive into AI-powered RNA-ISH analysis. RSVP by Friday, Feb 6, to reserve your spot: hcrimaging.typeform.com/to/qAGFCv2L

HCR™ Pro RNA-ISH for manual workflows is now compatible with all X1-X10 systems! This means you can use the HCR™ HiFi Probes you already have with manual HCR™ Pro, making it a strong option for challenging, low-abundance targets where maximizing sensitivity and signal-to-background matter most. 👉 New to manual HCR™ Pro? Request a complimentary Starter Kit: hcrimaging.typeform.com/manual-HCR-Pro 🛒 Ready to run extreme-sensitivity RNA imaging? Explore & order: store.molecularinstruments.com/new-kit/pro/rn…

HCR™ User Symposium | Speaker Spotlight We’re thrilled to have Nipam Patel joining the HCR™ User Symposium to share real examples of how multiplex HCR™ imaging can reveal developmental patterns in context. Boston, MA | February 19, 2026 | 10:00 AM–3:00 PM As a thank you for attending, all participants will receive a complimentary HCR™ HiFi Probe (target of your choice) to bring HCR™ workflows back to your lab. Registrations close this Friday, Feb 6. Hope to see you there! hcrimaging.typeform.com/to/qAGFCv2L

We’re excited to welcome @Visiopharm to the HCR™ User Symposium in Boston on February 19, 2026! Daniel Winkowski, their Senior Technical Sales Specialist, will share a quick introduction to Visiopharm’s software, followed by a live demo featuring real-time image analysis on HCR™ data. Get your registration in by Feb 6! And as a thank-you for joining us, all attendees will receive a complimentary HCR™ HiFi Probe for any target of their choice. Register here: hcrimaging.typeform.com/to/qAGFCv2L

✨ HCR™ Gold Q&A: Your Top Questions Answered✨ We’ve heard your questions, and in this segment, we’re breaking down everything you want to know about HCR™ Gold RNA-FISH. From workflow tips to performance details, swipe through our carousel to see all the answers and discover why HCR™ Gold is the go-to choice for robust, versatile RNA-FISH. Order HCR™ Gold here: tinyurl.com/4jj6uvvd

HCR™ User Symposium | Speaker Spotlight We’re keeping our Speaker Spotlight series going as we count down to Boston! • Jong Gwan Lee will present molecular and cellular evidence for lateralized asymmetries of anterior somites. • Henry Bushnell will discuss how Notch signaling balances distinct neurogenic states during embryonic retinal development. ✅ Free to attend + lunch provided 🎁 Bring a friend! All attendees will receive a complimentary HCR™ HiFi Probe (target of your choice). 🗓️ February 19, 2026 🕤 10:00 AM–3:00 PM 📍 Boston, MA Register by Feb 6 to save your spot: hcrimaging.typeform.com/to/qAGFCv2L

We’re excited to welcome Elizabeth Hicks-Kridel to the MI team as our Senior Director, Global Head of Sales. Elizabeth brings extensive life sciences experience that will further elevate our growing commercial organization, and we’re looking forward to the impact she’ll have as we continue building and scaling together. Welcome, Elizabeth!

HCR™ User Symposium | Speaker Spotlight This is the first of many Speaker Spotlights as we preview the guest speakers joining us in Boston: • Evan Ratzan will discuss how HCR™ RNA-FISH reveals heterogeneous gene expression in inner ear sensory epithelia. • @davidhbrann will share insights on validating spatial maps in the nose using the HCR™ platform. Across a full day of curated sessions, you’ll hear real-world HCR™ applications from leading academic researchers and learn from image analysis experts on how to get more from your HCR™ data downstream. This event is free to attend, and lunch will be provided. All attendees will also receive a complimentary HCR™ HiFi Probe for a target of your choice as a thank-you for joining us. If you’re in the Boston area, we’d love to connect! 🗓️ February 19, 2026 🕤 10:00 AM–3:00 PM 📍 Boston, MA Register by Feb 6 to save your spot: hcrimaging.typeform.com/to/qAGFCv2L

✨ HCR™ Gold vs. HCR™ (v3.0) ✨ As we continue our HCR™ Gold spotlight series, swipe to learn how HCR™ Gold differs from HCR™ (v3.0). HCR™ (v3.0) has supported countless research workflows and remains supported for ongoing experiments. HCR™ Gold builds on that foundation as our forward-looking platform, delivering more robust performance, higher resolution, and seamless compatibility with the HCR™ HiFi Encoder. 💡New to HCR™ Gold? Request a complimentary Starter Kit: hcrimaging.typeform.com/FISH-StarterKit 🛒 Ready to order? Shop HCR™ Gold: molecularinstruments.com/shop