James Haber

@TabathaWal14478 @TheTennisLetter To take Alcaeaz to 7-5 in 4th, as a 38 yr old. Amazing

@TheTennisLetter Que horror... Djokovic le daño el camino a Sinner y para que ... Para salir con un chorro de babas🤮🤮🤮🤮🤮😡😡😡

Novak Djokovic says he will not talk about anything he was struggling with physically during his match against Carlos Alcaraz at Australian Open: “I never liked to talk about things that I go through physically or health wise. It’s going to come across as I’m looking for excuses and taking away credit of the winner. So it’s not gonna change this time. I’m just gonna congratulate Carlos and he was the deserved winner on the court today.” (via Australian Open Press)

@xy99266 @NEWSMAX You hsve a dhort memory. See student loans.

@NEWSMAX This is so frustrating. When Biden was president his actions never go to court and being questioned 👿

A federal judge ordered the Department of Homeland Security to restore DHS grant funding to New York and other states after ruling that the funding cuts were unlawful. bit.ly/4jhKi0C

@RepClayHiggins family of 4: $4200/52 = $80.75 a week. You probably "properly shop" for more wine a week than that. How do you end up so heartless?

There are 22 million American households receiving SNAP benefits for groceries, at $4200 per year on average. Try to get your head wrapped around how many pantries you can stock with $4200 dollars in properly shopped groceries.   Any American who has been receiving $4200 dollars per year of free groceries and does NOT have at least 1 month of groceries stocked should never again receive SNAP, because wow, stop smoking crack.

@McMurraylab In S288c - the reference genome - HMRA has a "stuck" mutatiion that has reduced HO cutting when at MAT. and when MATa-stk switches to MATalpha-stk it is sterile (MATalpha1-minus) and even harder to switch.

Question for yeast folks, especially @Haberlab If intratetrad mating is most common post-meiotic event for wild S. cerevisiae, then MAT cassettes at HM should ~never be used & mutations there would escape purifying selection. Or are they sometimes used for spontaneous DSB repair?

@McMurraylab I rarely post, so sorry for the late reply.

@McMurraylab For what it's worth, HMRa in the reference genome is a "stuck" allele that greatly reduces HO cleavage. Moreover, when this same mutation at MATa-stk is switched to MATalpha-stk it is sterile (alpha 1-minus) and even more difficult to switch.

@McMurraylab good question. The assumption might be wrong - that in the wild intra-ascal matings are the norm; but it seems logical, and especially for heterothallic yeasts. I also don't know what fraction of wildtype yeast are homothallic. more below

@HarmitMalik @Barr_lab @gavinrrice Is there a list of the winners?

Before memory of #TAGC24 fades completely, @Barr_lab and I would like to thank the army of mostly postdoc poster judges. Extra special thanks to super-hero @gavinrrice who worked tirelessly for months to make sure all posters were visited multiple times, making them fun for all

@sgpombe @mcveylab Sorry I missed your talk. I'll look for the video.

How does a cell deal with stalled replication forks? Mitch McVey @Tufts_Biology shares @mcveylab efforts showing flies prefer using TLS over template switching for MMS repair & dissect REV1 & SLX1/SLX4 roles in TLS. #TAGC24 Ecol Genetics & Genomics/ Chrom Biol & #GenomeIntegrity

@JogerstKristen But doesn't anyone cover the weekend? Asking for someone who has called twice about hernia recovery.

No better way to end PGY-4. I was spoiled by my juniors with belated match day gifts. Being your senior resident has been the highlight of my year. Thanks for inspiring me to be a better resident, surgeon, and teacher. #TeamSurgOnc #DontStopBilivin

@aurelepiazza that would be nice!

Hi yeast experts: does anyone know of a mutant (or better, a conditional protein depletion) that causes a big change in yeast nuclear volume?

In antigenic variation in Lyme disease the vlsE surface protein gene is repeatedly changed by recombination with 15 adjacent pseudogenes. We tried to stimulate this in culture by cutting with Cas9. Mais non! Breaks cause loss of the immunity plasmid. biorxiv.org/content/10.110…

The 52nd Rosenstiel Award goes to two excepetional women: Erin Schuman and Christine Holt for their discoveries of the mechanisms of local protein translation that enables a neuron to get from the eye to the brain. brandeis.edu/now/2022/octob…

So suddenly I find myself looking for a new postdoc to work on double-strand break repair in yeast: mutations arising during gene editing and other types of DNA repair. Applicants should send a CV and cover letter to Jim Haber (haber@brandeis.edu). Please retweet!

An outrageous > 6-month delay by the USCIS in approving a waiver for my postdoc to remain in the US has led to her departure from my lab – she was not allowed to work or draw a salary while the wheels of bureaucracy ground on. What a mess! So now...

The Department of Biology at Brandeis University, Waltham, MA (Boston) seeks an instructor for the course BIOL 128, Human Genetics, in the Fall 2022 semester. brandeis.wd5.myworkdayjobs.com/Jobs/job/Brand…

@geneticssociety The Department of Biology at Brandeis University, Waltham, MA (Boston) seeks an instructor for the course BIOL 128, Human Genetics, in the Fall 2022 semester. brandeis.wd5.myworkdayjobs.com/Jobs/job/Brand…

Looking for a postdoc to study DNA repair in mitochondria. Unexplored territory. Please retweet. jobs.ascb.org/job/postdoc-in…