Not Hari Seldon

4.1K posts

Not Hari Seldon banner
Not Hari Seldon

Not Hari Seldon

@HariSeldomRight

Jr doc/postdoc | Amateur microcapper | Lucky picks $LEAT 8x (2020-22) $EPSIL 5x (2021-22) $CPH.TO 3x (2022-24) - apparently getting worse | 7y CAGR 42%

Stockholm, Sweden Katılım Nisan 2019
1.1K Takip Edilen4.2K Takipçiler
Sabitlenmiş Tweet
Not Hari Seldon
Not Hari Seldon@HariSeldomRight·
The main thing I learned this year is that I seem to perform better when I work in the psychiatric ward
Not Hari Seldon tweet mediaNot Hari Seldon tweet media
English
3
1
61
25.7K
Not Hari Seldon retweetledi
John Mandrola, MD
John Mandrola, MD@drjohnm·
Look: investors are better at trial appraisal than many Watchman proponents #acc26
John Mandrola, MD tweet media
English
12
27
185
42.2K
Not Hari Seldon
Not Hari Seldon@HariSeldomRight·
There are so many doctors who make the error of relying on mechanistic reasoning over empiricism
English
0
0
2
1.1K
Olle
Olle@89Olle·
Efter 26 timmar med mina älskade barn gav jag upp och öppnade en Celsius. Med föräldraskapet växer långsamt förståelsen för ensamstående föräldrar med cigg i ena handen och redbull i andra.
Svenska
28
0
179
66.7K
Unemployed Capital Allocator
Unemployed Capital Allocator@atelicinvest·
If your implied answer is "the same group as ones that own this now" - you should really hone in on what prevents them from owning it now. A decent way to suss out value traps
English
2
0
15
2.2K
Unemployed Capital Allocator
Unemployed Capital Allocator@atelicinvest·
Once again, we learn that it's easier to find new shareholders than to get the cheapest fucks in the market to bid up your stock.
English
4
6
113
19.8K
Not Hari Seldon
Not Hari Seldon@HariSeldomRight·
🤦‍♂️
TacticzHazel@TacticzH

🚨BIG NEWS FOR NOVO NORDISK! - $NVO 🚨 Today Novo Nordisk announced that Wegovy cuts risk of a heart attack, stroke or death by 57%!, when compared to Tirzepadite (which is from $LLY). I'm not blown away. Novo Nordisk said: ''This result adds to the growing evidence that the heart-protective benefits seen with Wegovy are specific to the Semaglutide molecule and therefore cannot be extended to other GLP-1 or GIP/GLP-1-based treatments''. Key findings from the study: ✅In patients who stayed on treatment, Wegovy reduced the risk of heart attack, stroke, or death by 57% compared to tirzepatide. ✅In all treated patients (including those with treatment gaps), Wegovy showed a 29% risk reduction for the same outcomes. Some people may dislike it, but I'm actually not a big fan of how Novo published this. Here is why: ❌ The study reports averages of 3.8–8.6 months, which is very short for cardiovascular outcomes. Many events occur over years, not months. A “57% reduction” over such a brief window can look dramatic but may not translate the same way long term. ❌ Reporting a “57% reduction” sounds huge, but the absolute numbers were small (15 vs. 39 events out of >10,000 patients per arm). The absolute risk difference was ~0.3% — which is meaningful but not nearly as dramatic as “57%”. ❌Real-world studies (like STEER) are prone to biases even with matching. They cannot prove causation the way randomized controlled trials do. I like the fact that they are more aggressive, and also love the fact they are targeting $LLY here. But I would love more significant results behind these 'results''/news details. Still, the potential is clearly there for Novo. Still bullish! What do you think?

ART
1
0
3
5.3K
Not Hari Seldon
Not Hari Seldon@HariSeldomRight·
@TacticzH I'd remove the tweet if I were you. It's highly misleading and most of your readers clearly can't tell. You're contributing with negative knowledge to your readers i.e. they will be less informed after reading your tweet.
English
2
0
1
177
jarmo friman
jarmo friman@JarmoFriman·
Merkittävää, jos isot aineistot vahvistavat. Nousuviikko tulossa?
TacticzHazel@TacticzH

🚨BIG NEWS FOR NOVO NORDISK! - $NVO 🚨 Today Novo Nordisk announced that Wegovy cuts risk of a heart attack, stroke or death by 57%!, when compared to Tirzepadite (which is from $LLY). I'm not blown away. Novo Nordisk said: ''This result adds to the growing evidence that the heart-protective benefits seen with Wegovy are specific to the Semaglutide molecule and therefore cannot be extended to other GLP-1 or GIP/GLP-1-based treatments''. Key findings from the study: ✅In patients who stayed on treatment, Wegovy reduced the risk of heart attack, stroke, or death by 57% compared to tirzepatide. ✅In all treated patients (including those with treatment gaps), Wegovy showed a 29% risk reduction for the same outcomes. Some people may dislike it, but I'm actually not a big fan of how Novo published this. Here is why: ❌ The study reports averages of 3.8–8.6 months, which is very short for cardiovascular outcomes. Many events occur over years, not months. A “57% reduction” over such a brief window can look dramatic but may not translate the same way long term. ❌ Reporting a “57% reduction” sounds huge, but the absolute numbers were small (15 vs. 39 events out of >10,000 patients per arm). The absolute risk difference was ~0.3% — which is meaningful but not nearly as dramatic as “57%”. ❌Real-world studies (like STEER) are prone to biases even with matching. They cannot prove causation the way randomized controlled trials do. I like the fact that they are more aggressive, and also love the fact they are targeting $LLY here. But I would love more significant results behind these 'results''/news details. Still, the potential is clearly there for Novo. Still bullish! What do you think?

Suomi
9
1
67
11.9K
Not Hari Seldon
Not Hari Seldon@HariSeldomRight·
@TacticzH It's a massive overinterpretation of an observational treatment comparison presented at the ESC congress. Not an RCT. Not even a full paper. It has likely not even undergone peer review. You can use it as toilet paper.
English
2
0
3
248
Not Hari Seldon
Not Hari Seldon@HariSeldomRight·
The reason I give such low allocation to the best stocks is so that I don't become too concentrated when they multibag on me. And vice versa.
English
1
1
11
2.2K
Not Hari Seldon
Not Hari Seldon@HariSeldomRight·
Is there any really cheap and compelling stock out there right now?
English
18
3
24
12.2K
David
David@FischerRandom1·
@HariSeldomRight Plenty of them. $LULU, $DEO, $ADBE, $NVO to name a few
English
1
0
0
640
SharpeShark
SharpeShark@SharpeShark·
@HariSeldomRight $ADBE still fits the bill, and has come off lows nicely. If $COHR fell to $80ish ex-news I’d be tempted to full port it, but nice here as well even if a little risky from a datacenter capex pov depending on where you think we are in that cycle.
English
1
0
2
1.1K
Not Hari Seldon retweetledi
Andrew Colburn
Andrew Colburn@ndrewColburn·
Sometimes a mother’s “spidey sense” is better than industry analysts’ opinions. $SRPT (from a year ago)
English
8
27
230
41.7K
Not Hari Seldon
Not Hari Seldon@HariSeldomRight·
@atelicinvest I think I disagree with you on this one (it depends on degrees of course but in general). Not so much the 70 vs 100 years part but the fat part.
English
1
0
0
371
Not Hari Seldon
Not Hari Seldon@HariSeldomRight·
Most people should increase their temperature
English
2
0
5
2.8K