Wanli He

@ChiDwi_Tweets @mims_umea @NordicEMBL @KliniskMB @umeauniversity @scilifelab @KAWstiftelsen @BackhedLab congrats！ and best wish for your new position 😁

Delighted to start my new lab at @mims_umea @NordicEMBL @KliniskMB @umeauniversity also for receiving research support as a DDLS fellow @scilifelab @KAWstiftelsen. Beyond grateful to my mentor Prof Fredrik Bäckhed @BackhedLab who kept believing in me and a big thanks to my family

@Ella_Maru Thanks

@He6Wanli Thanks for the detailed response, Wanli! Keep up the great work!

Excited to share my latest publication in Nature Communications! 🚀 Our study uncovers the remarkable diversity of plasmids in the infant gut microbiome, highlighting their crucial role in early gut. nature.com/articles/s4146…

I’m thrilled to share the recording of my phd thesis defense presentation! 📽️ In this talk, I delve into "Plasmids metagenomic: insight into their cryptic ecology" You can watch the full presentation here: youtu.be/6tP6qEq4-vk

@Ella_Maru some disease are relevant to gut microbial disorder. and it is hard to say the role of plasmid-lossing-mediated micrbial structure changing on these disease.

@He6Wanli Congratulations, Wanli! Could early-life plasmid diversity be a critical factor in microbiome development, and what are the potential consequences of its disruption?

@Ella_Maru if the plasmid community is disrupted, maybe it will distroy the balance of competition and cooperation in colony structure, thereby affecting microbial community structure, but it is hard to say what will casued by this changing, but at least some results already showed that

@Ella_Maru Thanks!i will believe that, specially during the colonization stage, plasmid can imporve their competitiveness compare to other non-plasmids carriers, as least by obtains extral genes (HGT) or/and new traits (high copy number plasmid has higher and faster mutation)

@txurv @jnesme thanks man！

@He6Wanli Congratulations Wanli and @jnesme! An absolute tour de force into the early life microbiome! First of many cool studies I’m sure.

The role of plasmids in the gut microbiome during the first year of life biorxiv.org/cgi/content/sh… #biorxiv_micrbio