Herasight

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Herasight

Herasight

@herasight

Building the highest quality genetic tests for families.

Katılım Haziran 2025
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Herasight
Herasight@herasight·
Fresh from the printing press! Our paper has now been peer reviewed and published. CogPGT 1.0 up to triples the variance explained over previous genetic predictors of IQ, allowing parents to predict significant cognitive differences between embryos.
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Tobias Wolfram@_twolfram

Today the worlds most powerful genetic predictor of IQ, CogPGT, has been published in the peer reviewed journal Intelligence and Cognitive Abilities. When used for embryo screening, it can substantially boost expected IQ of future offspring. Read on for the scientific details!

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Cat Powered ⚡🐈
Cat Powered ⚡🐈@cat_powered·
Herasight are absolute gigachads.
Herasight@herasight

Herasight does genetic testing of embryos, but we keep discovering people’s unknown medical conditions as a side-effect of our work. A few months ago we sequenced the genome of one of our employees and discovered he had an unusually high risk of psoriasis. He had a higher risk than 97% of the general population, largely thanks to the presence of HLA-C*06:02/PSORS1. For years, his mother had been suffering from a mysterious illness causing increasingly severe neck and back pain. It would often take her an hour or more to get out of bed in the morning. She had seen doctors multiple times over the years and described her symptoms, but they chalked it up to age-related mechanical back pain. She was told to get a different pillow and to replace her mattress. None of it helped. Her symptoms continued to worsen and her daily dose of pain relievers continued to climb. When our employee received his genetic risk report, he immediately began to wonder whether his high risk might be connected to her symptoms. Sure enough, when we sequenced her genome, his suspicions were confirmed. Her risk was higher than that of 99.3% of the general population! She immediately visited a rheumatologist and was diagnosed with psoriatic arthritis! The doctor put her on a DMARD, which has finally improved her symptoms. But what about his children? Will they inherit his high risk of this disease, just like he did from his mother? Fortunately, the answer is probably not! When we looked at his embryos we found not only do some have lower risk than him, one actually has a risk even lower than average! If you’ve got a family history of some disease you want to avoid passing on to your kids, please reach out! We can often help you lower that risk for your children. cal.com/team/herasight…

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Herasight
Herasight@herasight·
Herasight does genetic testing of embryos, but we keep discovering people’s unknown medical conditions as a side-effect of our work. A few months ago we sequenced the genome of one of our employees and discovered he had an unusually high risk of psoriasis. He had a higher risk than 97% of the general population, largely thanks to the presence of HLA-C*06:02/PSORS1. For years, his mother had been suffering from a mysterious illness causing increasingly severe neck and back pain. It would often take her an hour or more to get out of bed in the morning. She had seen doctors multiple times over the years and described her symptoms, but they chalked it up to age-related mechanical back pain. She was told to get a different pillow and to replace her mattress. None of it helped. Her symptoms continued to worsen and her daily dose of pain relievers continued to climb. When our employee received his genetic risk report, he immediately began to wonder whether his high risk might be connected to her symptoms. Sure enough, when we sequenced her genome, his suspicions were confirmed. Her risk was higher than that of 99.3% of the general population! She immediately visited a rheumatologist and was diagnosed with psoriatic arthritis! The doctor put her on a DMARD, which has finally improved her symptoms. But what about his children? Will they inherit his high risk of this disease, just like he did from his mother? Fortunately, the answer is probably not! When we looked at his embryos we found not only do some have lower risk than him, one actually has a risk even lower than average! If you’ve got a family history of some disease you want to avoid passing on to your kids, please reach out! We can often help you lower that risk for your children. cal.com/team/herasight…
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Alex Strudwick Young
Alex Strudwick Young@AlexTISYoung·
LLM genome analysis seems to combine half baked analyses with pleasing sounding over-interpretations. This isn't a substitute for a properly validated analysis using state of the art data and methods. It may be more like a genomic horoscope.
Claire Lehmann@clairlemon

@AlexTISYoung Got it. Here's the output from Claude.

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Alex Strudwick Young
Alex Strudwick Young@AlexTISYoung·
Doing properly calibrated and powerful risk predictions from genome data is hard and shouldn't be left to general AI agents. It's a failure of the consumer genomics industry that rich people resort to this rather than getting properly validated commercial reports.
Patrick Collison@patrickc

I'm lucky enough to have a great doctor and access to excellent Bay Area medical care. I've taken lots of standard screening tests over the years and have tried lots of "health tech" devices and tools. With all this said, by far the most useful preventative medical advice that I've ever received has come from unleashing coding agents on my genome, having them investigate my specific mutations, and having them recommend specific follow-on tests and treatments. Population averages are population averages, but we ourselves are not averages. For example, it turns out that I probably have a 30x(!) higher-than-average predisposition to melanoma. Fortunately, there are both specific supplements that help counteract the particular mutations I have, and of course I can significantly dial up my screening frequency. So, this is very useful to know. I don't know exactly how much the analysis cost, but probably less than $100. Sequencing my genome cost a few hundred dollars. (One often sees papers and articles claiming that models aren't very good at medical reasoning. These analyses are usually based on employing several-year-old models, which is a kind of ludicrous malpractice. It is true that you still have to carefully monitor the agents' reasoning, and they do on occasion jump to conclusions or skip steps, requiring some nudging and re-steering. But, overall, they are almost literally infinitely better for this kind of work than what one can otherwise obtain today.) There are still lots of questions about how this will diffuse and get adopted, but it seems very clear that medical practice is about to improve enormously. Exciting times!

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Blurghgh
Blurghgh@nor82883·
@AlexTISYoung @tbpn PGT p is still a tough sell in Australia but an Aus retrospective validation study would be genuinely useful. I work in PGT here (Virtus health) would HeraSight be open to a collaboration like that? Appreciate it’s a left-field ask.
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Alex Strudwick Young
Alex Strudwick Young@AlexTISYoung·
How powerful is polygenic testing for diseases in IVF? My answer from my recent @tbpn interview.
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Herasight
Herasight@herasight·
And check out our IVF calculator if you want a sense of how many eggs it takes to create an embryo given your age and fertility profile: herasight.com/ivf-calculator
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Herasight
Herasight@herasight·
If you are considering fertility preservation, check out this excellent article on egg freezing!
Ruxandra Teslo 🧬@RuxandraTeslo

It's a myth that egg freezing doesn't work. It works extremely well for women who freeze young. It has low success rates for women in their 40s and late 30s, when fertility has already declined significantly. - Women who freeze enough of their eggs in their twenties have the same success rate using those eggs later as they would have had using them fresh in their twenties: 85-90%. -Women generally freeze too few eggs and too late (median age: 37). This is why overall success rates reported in papers are low. - Women's fertility does not drop off rapidly after age 35. That's a myth caused by faulty data. The decline is earlier and more linear. - Clinics in Spain are significantly cheaper but just as good or better than British or American ones in success rates. I got my eggs frozen in Valencia last week. - Clinic choice matters a lot. Average success rates can vary between 25% to more than 60% probability of live birth per embryo transfer for the worst and best clinics, respectively. worksinprogress.co/issue/were-fre… @_revoluzia_ and I are both in our late 20s, and both decided to get our eggs frozen, so that we could definitely have the number of children we wanted, regardless of where life takes us. Recent technological improvements make egg and embryo freezing an effective 'fertility insurance'. We share our lessons from the process in a new article for Works in Progress.

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Ruxandra Teslo 🧬
Ruxandra Teslo 🧬@RuxandraTeslo·
It's a myth that egg freezing doesn't work. It works extremely well for women who freeze young. It has low success rates for women in their 40s and late 30s, when fertility has already declined significantly. - Women who freeze enough of their eggs in their twenties have the same success rate using those eggs later as they would have had using them fresh in their twenties: 85-90%. -Women generally freeze too few eggs and too late (median age: 37). This is why overall success rates reported in papers are low. - Women's fertility does not drop off rapidly after age 35. That's a myth caused by faulty data. The decline is earlier and more linear. - Clinics in Spain are significantly cheaper but just as good or better than British or American ones in success rates. I got my eggs frozen in Valencia last week. - Clinic choice matters a lot. Average success rates can vary between 25% to more than 60% probability of live birth per embryo transfer for the worst and best clinics, respectively. worksinprogress.co/issue/were-fre… @_revoluzia_ and I are both in our late 20s, and both decided to get our eggs frozen, so that we could definitely have the number of children we wanted, regardless of where life takes us. Recent technological improvements make egg and embryo freezing an effective 'fertility insurance'. We share our lessons from the process in a new article for Works in Progress.
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Herasight
Herasight@herasight·
@RuxandraTeslo Really nice work! For anyone interested, we created an IVF calculator that can give a sense of how many eggs it takes to get a certain number of embryos (taking into account the age when the eggs were collected): herasight.com/ivf-calculator
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Alex Strudwick Young
Alex Strudwick Young@AlexTISYoung·
My full interview on TBPN where I talk about: -polygenic prediction in IVF -regulation of genetic testing in IVF -the utility of biobanks -my own experience as a cancer patient -the future of reproductive medicine A much better discussion than Kian Sadeghi on Tucker...
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TBPN
TBPN@tbpn·
Herasight advisor and genetics professor @AlexTISyoung says that in the future, we may be able to create gametes from non-gamete adult cells and stack that with gene editing to remove disease-causing variants: "In vitro gametogenesis is a technology to create gametes — so sperm and eggs, eggs is what would be more useful generally — from adult cells that are not gamete cells." "That could potentially create thousands of embryos." "Then there's also gene editing. You can use CRISPR or a technology like that to go into an embryo and edit particular base pairs, remove some disease-causing variant, or maybe more controversially enhance some ability." "My idea for the future of this space could be that you have a stack, where you have in vitro gametogenesis that creates thousands of embryos. Then you can get the genome data, do the predictions of the disease risks and traits from that, select a few promising embryos, and then do some edits in them."
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Producer Ben
Producer Ben@RealProducerBen·
RECENTLY ON @tbpn
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Jonathan Anomaly
Jonathan Anomaly@JonathanAnomaly·
The legendary @AlexTISYoung on @tbpn today:
TBPN@tbpn

Herasight advisor and genetics professor @AlexTISyoung says that in the future, we may be able to create gametes from non-gamete adult cells and stack that with gene editing to remove disease-causing variants: "In vitro gametogenesis is a technology to create gametes — so sperm and eggs, eggs is what would be more useful generally — from adult cells that are not gamete cells." "That could potentially create thousands of embryos." "Then there's also gene editing. You can use CRISPR or a technology like that to go into an embryo and edit particular base pairs, remove some disease-causing variant, or maybe more controversially enhance some ability." "My idea for the future of this space could be that you have a stack, where you have in vitro gametogenesis that creates thousands of embryos. Then you can get the genome data, do the predictions of the disease risks and traits from that, select a few promising embryos, and then do some edits in them."

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