Timothy Hinks

Simon and Fleur's new paper is out in The Lancet Respiratory Medicine! ORACLE2 pooled 6,500+ asthma patients from 22 RCTs. 🧪 Blood eosinophils + FeNO = key predictors of asthma attacks 💨 Reversibility = lower risk? Open access: thelancet.com/journals/lanre… #asthma #ORACLE2

The 'Dream Combo' in #EosinophilicAsthma: for those on #asthma biologics with persistent mucopurulent cough additional long term, low dose azithromycin is highly effective. Gabriel's findings from @OxfordBRC out today in thorax.bmj.com/content/early/…

open.spotify.com/show/3Oq0my5s8… great new podcast chaired by Paul Klenerman interviewing colleagues about fascinating immunology.

The new NICE/BTS/SIGN #Asthma guidelines are superb. A collaborative approach. A focus on using blood eos and FeNO at initial presentation and finally the long-overdue end to salbutamol. Read it and use it now nice.org.uk/guidance/NG245

Wonderful to see Imran Howell from @OxfordBRC announced this year's BTS Young Investigator Award winner for delivering the BOOST trialin #asthma. Well deserved! #RespIsBest

1 million people switched from Twitter / X to BlueSky today. Come and follow us there, now on @hinkslab.bsky.social

Out today doi.org/10.1016/j.muci… our collaborator Adam Byrne shows airway macrophage glycolysis controls lung homeostasis and responses to aeroallergens. Exposure to house dust allergen drove glycolysis in alveolar macrophages; inhibiting this altered inflammation, via TLR2.

When exacerbations of severe #asthma occur despite being on type 2 biologics, what residual inflammation remains? In our latest paper from @OxfordBRC we show prednisolone caused broad down regulation of type 2 pathways in pts on mepolizumab. Full report: doi.org/10.1016/j.jaci…

Our new species-level study from @OxfordBRC shows severe #asthma microbiome is dominated by H. influenzae, M. catarrhalis and S. pneumoniae, driving neutrophilic inflammation, airway proteases and disrupting regulatory immune responses: doi.org/10.1111/all.16…

Today is #WorldAsthmaDay. @ALUK_research are showcasing why understanding your asthma triggers is so important to condition management. Visit the @asthmalunguk website to find out more.  bit.ly/44kkSb7

A 2 minute summary of our unexpected finding from @NDMOxford of tonic type 2 signalling in the airway mucosa in health. youtube.com/watch?v=inNYVj… funded by @asthmalunguk

Out today: an unexpected discovery from our Leicester/Oxford healthy volunteer bronchoscopy study. In health there is constitutive type 2 signalling within the airway mucosa, which is exquisitely sensitive to ICS. Read it now in doi.org/10.1111/all.16…

Want to find out more about azithromycin in acute and chronic respiratory disease? Join our ERS webinar on 14th May ersnet.org/events/azithro…

How can we help the 2/3 of people with a high FeNO who aren't using their inhalers adequately? As Fostair NEXThaler counter only triggers at an adequate inspiratory flow rate, the Leicester group have used dose counting with FeNO to detect non adherence. doi.org/10.1016/j.jaip…

In a murine model of sterile lung injury we found MAIT cells enhance defence against sterile lung injury by fostering cDC1-driven anti-fibrotic pathways. Read more about this #research from @NDMOxford on bioRxiv today biorxiv.org/content/10.110…

Fantastic few days at #BTSWinter2023 ! Wonderful science as always. Huge privilege to present my PhD work. Thanks to @asthmalunguk @BTSrespiratory @HinksLab

A problem confounding nearly every transcriptomic or histology study in asthma is the steroid effect. So what happens when ICS are given to healthy people? Find out at doi.org/10.1101/2023.1… including an unexpected discovery - homeostatic type 2 signalling in health!

The public are invited to a webinar hosted by @NIHRCRN_tvsm to ask questions of University of Oxford expert Prof Tim Hinks about the latest research into asthma 📅 Wednesday 17 May 🕛 7pm to 8pm. Read more and sign up: ow.ly/LFSb50NMxYP #asthma #asthmaresearch

Out today, NTHi is internalised by primary bronchial epithelial cells. It activates innate responses including CXCL8, IL-1β, IL-6 and TNF, independently of invasion, with more activation in nasal than bronchial cells, despite NTHi being a nasal commensal. doi.org/10.3389/fcimb.…

Delighted to see this well deserved spotlight article on Sanjay Ramakrishnan in TLRM - a future global respiratory leader to watch, and such a nice guy too #fx1" target="_blank" rel="nofollow noopener">thelancet.com/journals/lanre…