Ingie Hong

Delighted to announce the opening of my lab at KAIST in Daejeon. My lab will focus on intellectual disability proteins and their impact on brain computations. I'm hiring! For more details, visit ingiehonglab.org. Please RT! Recommendations are welcomed.

Now published in PNAS! Congrats to my amazing colleagues Julia and Blaise & postdoctoral mentor Rick! pnas.org/doi/10.1073/pn… Here we've dissociated enzymatic vs structural roles of SYNGAP1 in excitability and seizures. This will inform treatment development for this NDD!

Congrats to my dear colleagues Julia Brill, Blaise Clarke, and Rick Huganir! And thanks to the many people who helped with this research. Lastly, thanks to @cureSYNGAP1 and all Syngapian families who inspired our science.

Excited to share our new preprint on #SYNGAP1 that shows how its enzymatic and structural role can be dissociated! The GAP activity is essential in increasing intrinsic excitability but does not contribute to the seizure protection SynGAP is important for. biorxiv.org/content/10.110…

We're thrilled to present ESM3 in @ScienceMagazine. ESM3 is a generative language model that reasons over the three fundamental properties of proteins: sequence, structure, and function. Today we're making ESM3 available free to researchers worldwide via the public beta of an API for biological intelligence. Trained with over a trillion teraflops of compute, this is the first time a model of this scale has been trained for biology, pushing the frontier of AI for biological discovery and engineering. ESM3 learns to represent the immense complexity of protein biology, learning from billions of natural proteins. From this training it developed the capability to design proteins, responding to complex prompts combining atomic level details and high level instructions to generate new proteins. ESM3 can explore protein space far beyond natural evolution. We prompted ESM3 to generate a fluorescent protein at a far distance from any known fluorescent proteins, searching an unknown region of protein space, to discover a new fluorescent protein. We estimate this is equivalent to simulating five hundred million years of evolution.

@eunji_kkong @attila_losonczy @ZuckermanBrain I really enjoyed reading this! Congrats!

“How does local circuit architecture shape spatial representations in the hippocampal CA3?” ✨Excited to share my first postdoc work in @attila_losonczy lab @ZuckermanBrain now online as a preprint.✨ Check the link below👇 biorxiv.org/content/10.110…

Our paper on MouseGoggles - an open-source mini VR headset for mice - just came out! Really excited about finally integrating eye-tracking into the headset. Nice working with you @hongyu_chang! nature.com/articles/s4159… github.com/sn-lab/MouseGo…

Amazing work by @Han_L_Tan! These BNC2 neurons shut down hunger before you can pronounce semaglut-. Lots of implications for understanding and treating obesity 🧠🍽️ #Neuroscience #ObesityResearch #Leptin

Brain Molecule Makes Neurons Less Selective Deepening Understanding of Human Cognition—Findings from Johns Hopkins Medicine may help scientists better understand causes of autism, schizophrenia and epilepsy. “We've discovered that the calcium permeable subtype of AMPA receptors has an added role of suppressing the selectivity of a given neuron,” says Ingie Hong, Ph.D., first author and an instructor in neuroscience at the Johns Hopkins University Medicine. “Until now, the role of these specific receptors in the wider mammalian brain as it functions in everyday life has been a mystery.” Full article: oneneurojhu.org/2024/10/14/bra…

@susanmagsamen kicking off #sfn24 on the power of #NeuroArts, mixing in some tips on dating and @rhuganir 's back-of-the-napkin explanation of first kiss neuroscience

@Michael_Xupb @Nature @thainmueller @rhuganir Thanks!

@Ih_current @Nature @thainmueller @rhuganir wow, this is gorgeous! Congrats!

Why are some neurons more selective than others? We report now in @Nature how calcium permeable-AMPA receptors in PV neurons make them less selective to sensory features nature.com/articles/s4158… Long live the geniuses behind this🧠🔍juhyun.kim @thainmueller @rhuganir

@Hyun_neuron_10 @Nature @thainmueller @rhuganir Thanks Jungho!

@Ih_current @Nature @thainmueller @rhuganir Tons of work done with smartest collaborative groups! Congrats to Ingie and the team!! 🥳

@adelineeyong @Nature @thainmueller @rhuganir Thanks Adeline!

@Ih_current @Nature @thainmueller @rhuganir Congrats Ingie!!!!

@jojo_zn_yang Thanks Jojo! You're amazing and you know it.

Proud to be part of the work! Very grateful for the mentorship from @Ih_current ♥️

@SethBlackshaw Thanks Seth!

@Agarwalneurolab Indeed my friend.

Many congratulations @Ih_current and the team for a superb work 🍻Indeed beer hold a special palce in many discoveries. It was fun to work with you at early stages of the project, and feel honored to be part of it. Waiting to have another beer with you.

@alexei_bygrave Thanks Alexei! You're a Force Multiplier with no match.

@Hyun_neuron_10 @rhuganir Thanks Jungho!

Massive congratulations on the publication, Ingie(@Ih_current) and the team @rhuganir —this is an incredible achievement with such a huge collaborative effort!