Basic & Clinical Immunology FMUP

In a network meta-analysis reviewing biologics targeting IL-4/IL-13, IL-5, or IgE axes, dupilumab is the most effective type 2-targeted biologic for CRSwNP. Previous sinus surgery was not a relevant effect modifier. authors.elsevier.com/a/1lRke7tEbbUh…

This study underscores the importance of daily dietary choices - meal quality acutely impacts autonomic nervous system responses & airway inflammation, with potential cardiometabolic & respiratory health implications.DOI:10.3390/nu17040614 #AIMedEd @FMUPorto @Nutrients_MDPI #mdpi

Progressive pulmonary fibrosis (PPF), a complication in several interstitial lung diseases other than idiopathic pulmonary fibrosis, associates with elevated serum MMP-7 levels, potentially identifying patients at risk of progression. doi.org/10.1183/231205… #AIMedEd @FMUPorto

In both healthy and allergic rhinitis, the nasal cavity is a major reservoir of allergenic or opportunistic fungi. Rhinitis and comorbid asthma had higher and more diverse mycobiome networks, overexpressing 3 pathways of AIR biosynthesis doi.org/10.3389/fmicb.… #AIMedEd @FMUPorto

International Consensus on Pollen-Food Allergy Syndrome management: the benign self-limited nature of oral symptoms, educating on risks, avoiding trigger foods and the exceptional need for epinephrine autoinjectors. pubmed.ncbi.nlm.nih.gov/39488768/ #AIMedEd @FMUPorto

A comprehensive guide to office procedures for evaluating and managing ocular surface disorders, with a specific focus on ocular allergies and dry eye syndrome. #AIMedEd @FMUPorto More at:pubmed.ncbi.nlm.nih.gov/39133190/

A cross-sectional analysis of 3458 teens links higher transepidermal water loss (TEWL) to gender and allergic comorbidities. Findings highlight the role of skin barrier disruption in allergic inflammation. #AIMedEd @FMUPorto. More at: pubmed.ncbi.nlm.nih.gov/39109484/

Adherence to a sustainable diet is linked to lower airway inflammation in school-aged children, particularly those without overweight/obesity. Healthier eating patterns for Planetary Health may also improve respiratory health! #AIMedEd @FMUPorto GVA: tinyurl.com/26vr26kz

Ocular allergy involves immune hypersensitivity affecting the eye's surface. Often overlooked, various symptoms may significantly impact quality of life. This article explores a multidisciplinary approach to diagnosis and treatment. tinyurl.com/ccvyttam #AIMedEd @FMUPorto

Obesity and Sodium? Higher urinary sodium, representing high salt intake, is associated with increased body fat in children, independent of energy intake. This highlights the need to reduce high-sodium diets for better health. #AIMedEd #Obesity @FMUPorto tinyurl.com/2s4ykxax

New research highlights the impact of students' ambiguity aversion to multiple-choice exam performance. An intermediate level of ambiguity aversion (as opposed to a very high or low level) led to more correct answers and fewer blanks! pubmed.ncbi.nlm.nih.gov/38224412/ #AIMedEd @FMUPorto

Under and overdiagnosis are potential issues in drug hypersensitivity in children. Review recent findings in antibiotics, vaccines, antiepileptic hypersensitivity and severe cutaneous adverse reactions in children at doi.org/10.3389/falgy.… #AIMedEd @FMUPorto

Open Access: Heterogeneity of sensitization profiles and clinical phenotypes among patients with seasonal allergic rhinitis in Southern European countries—The @IT.2020 multicenter study. First and corresponding author: S. Dramburg Read the article here: doi.org/10.1111/all.16… Within the @IT.2020 multicenter observational study, pediatric and adult patients suffering from seasonal allergic #rhinitis were recruited in nine study centers from seven countries. Sensitization profiles were very heterogeneous, but grass pollen major allergenic molecules were among the top three sensitizers in all study centers. Poly-sensitization was prevalent in Rome, Athens, and Tirana, while one single pollen was predominant in Valencia (olive), Marseille (cypress), Messina (pellitory), Porto, Istanbul, and Izmir (grass). #Allergy_journal @SDramburg Read more articles published in #Allergy on the #epidemiology of allergic diseases here: journalallergy.com/Epidemiology-a… onlinelibrary.wiley.com/toc/13989995/2… is a link to the March issue table of contents.

In mastocytosis, drugs tolerated after the onset should not be avoided.  To increase the safety when introducing new drugs, the use of pre-medication, safer alternatives, and drug challenges are recommended. #AIMedEd @FMUPorto   doi:10.1007/s40521-023-00349-2

ConectAR is a collaborative network involving patients with asthma and carers as active stakeholders in the co-creation of impactiful solutions for asthma. #AIMedEd  @FMUPorto  Doi: 10.23822/EurAnnACI.1764-1489.249 linktr.ee/redeconectar

Chronic rhinosinusitis with nasal polyps biological trials are still heterogeneous in inclusion criteria and secondary outcomes. Some recommendations to improve standardization will ensure comparability between primary studies.  #AIMedEd  @FMUPorto tinyurl.com/4st8ttnd

The potential association between hereditary α-tryptasemia and a higher risk for anaphylaxis or more severe anaphylaxis is plausible but lacks validatory evidence in large non-selected study populations. #AIMedEd @FMUPorto doi.org/10.23822/EurAn…

May diet influence your asthma? Review the role of specific dietary patterns and food groups in preventing asthma and their impact on airway inflammation - an intersection of food and lung health. #AIMedEd @FMUPorto @MDPIOpenAccess mdpi.com/2076-3417/13/1…

An update review of fungal causes of human diseases, its diagnosis and management: from allergy (ABPA, SAFS, occupational diseases), to immunodeficiencies (CMCC), mucocutaneous and systemic infections. #AIMedEd @FMUPorto @MDPIOpenAccess  mdpi.com/2309-608X/9/3/…