Inga-Maria Launonen

(1/7) ⭐️Chemotherapy induces myeloid-driven spatially confined T cell exhaustion in ovarian cancer⭐️ @Cancer_Cell we present dynamic changes induced by chemo in the TME and new insights into harnessing the immune system to combat ovarian cancer. sciencedirect.com/science/articl…

It was a pleasure to collaborate with @IngaMaria_L and @afarkkila! Huge congrats on amazing results and the paper! 🍾

(7/7) Special thanks also to #oncosys @Sampsa_H , @mijohy, @afenteva_daria, @jaanaoikkonen, @annimariav , @TuuliaVallius, @ajitjohnson_n, Decider and Oncosys-Ova cohorts and funders including @ERC_Research , @LaaketieteenS , @Syopasaatio, @tiedesaatio and @BiomedicumH ✨

(6/7) Read the paper to learn more! This study was supervised by @afarkkila and @AnnaVaharautio , I was responsible for the T-CycIF analyses, while Erdogan Erkan, Iga Niemiec and @MariaMHincapie took care of the scRNAseq, GeoMx and iPDC analyses.

(5/7) Importantly, the analysis of matched source tumors revealed correlations of TIGIT and NECTIN2 expression with the ex-vivo T-cell activation. #biomarkers

(1/7) ⭐️Chemotherapy induces myeloid-driven spatially confined T cell exhaustion in ovarian cancer⭐️ @Cancer_Cell we present dynamic changes induced by chemo in the TME and new insights into harnessing the immune system to combat ovarian cancer. sciencedirect.com/science/articl…

(4/7) ScRNAseq revealed that the TIGIT-NECTIN2 L-R interaction in CD8 T cells and Macrophages was induced by chemo, and targeting this pathway in immune-competent patient-derived cultures showed T-cell activation.

(3/7) CD8 T cell interactions with M1 and M2 macrophages contributed to patient prognosis in Myelonets as well as at the tumor-stromal interface, where the interactions with M2 macrophages were mutually exclusive with CD8 T cell - tumor cell interactions.

(2/7) After analyzing >100 chemo-naive and chemo-exposed tumor samples, we identified stuctures called ”Myelonets” - networks of myeloid cells - recurring across patient samples and driving T-cell exhaustion.

Last presentation before starting my maternity leave😅 Stay tuned for the publication!

🌟 Check our new pre-print about chemo-refractory #HGSC 🌟 I am lucky to work in such an amazing team, together with @TaruMuranen, @Sampsa_H, Rong Yu, @IngaMaria_L, @msalvadoresf, @KariLavikka, and others!

What changes occur within the #TME during chemotherapy in #HGSOC? Our new study delves into this remodeling through spatial and molecular analyses of chemo-naïve and chemo-exposed #HGSOC samples, revealing dynamic changes in immune cell states (🧵 1/8 ) biorxiv.org/content/10.110…

Interested in spatial tumor immunology?Unique opportunity to join our Lab! Please share! jobs.helsinki.fi/job/Helsinki-P… farkkilab.org @HiLIFE_helsinki @FIMM_UH @HelsinkiUniMed @iCAN_Finland

Last night's #Färkkilab pikkujoulu was epic! 🎉 December vibes and a potluck with flavors from around the globe 🌍🍲. A lab that eats together, stays together! 👩‍🔬👨‍🔬

We also visited collaborators @HiTSatHarvard , was nice to be back after over a year! Stay tuned for new results

Had a great time and learned a lot last week with @SystemTumor colleagues @afarkkila @FrandoPV @adajnq @ZiqiKang2000 and Iga visiting sunny Boston and #AACRovc23!🌞I was happy to present our work on the dynamic changes in the TME of ovarian cancer induced by chemotherapy💊

@pant_shishir @HelsinkiUniMed Thank you!😁

@IngaMaria_L @HelsinkiUniMed Congratulations Inga-Maria 🍾

Medical school graduation✅Time flies! @HelsinkiUniMed

My first international conference topped all expectations🤩Thank you #AACR23 for all the interesting presentations and discussions! Also it was great to present our poster on #ovariancancer #TME @SystemTumor #oncosys

Ovarian cancer single-cells from UMAP space back to spatial positions🤩made with @ajitjohnson_n s cool scimap toolkit! @SystemTumor #ovariancancer #oncosys #microenvironment