Sandeep Patel
2.4K posts
Sandeep Patel
@innovationwonk
PhD Nanoscientist | Making R&D work better | ex BARDA DRIVe Dir. @hhsgov | @TheNASEM Policy Fellow | @kidney_x Founder | Stuck in Pasteur’s Quadrant
Seattle Katılım Şubat 2012
1.5K Takip Edilen1.1K Takipçiler
The White House asked for community input on the future of the American scientific enterprise. Here is the response @amitgupta , @stuartbuck1 & I submitted.
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Sandeep Patel retweetledi
@jrkelly Yup.
Here are some more ideas from me and @innovationwonk in @statnews: statnews.com/2025/06/03/us-…
And here’s a great new piece from @RuxandraTeslo today: asimov.press/p/clinic-loop
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And now we have a system that rewards throughput over progress.
Part 3 in a 4-part series on rebuilding the architecture of science is now available.
open.substack.com/pub/catalyzern…
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We’ve built markets for just about everything except science.
There enormous friction for everything scientific progress needs transacted - money, ideas, collaborations, supplies, communicating progress, and most importantly, learning from itself.
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Exposomics is a natural evolution of genomics & can help illuminate the "dark matter" of human disease. Many features also make it commercially interesting.
(1) it's different for everyone and changes unpredictably (reason to keep getting tested)
(2) can identify an entirely new set of interventions
(3) there's a huge consumer appetite right now to understand their chemical exposure and what it means
Gary W Miller@GaryWMiller3
Genomics meets exposomics: historic meeting ushers in a new age of human health discovery, via @EurekAlert! @ColumbiaMSPH eurekalert.org/news-releases/… @innovationwonk @RimaHabre_ScD @nexusexposomics @DrJBhattacharya @
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Sandeep Patel retweetledi
Genomics meets exposomics: historic meeting ushers in a new age of human health discovery, via @EurekAlert! @ColumbiaMSPH eurekalert.org/news-releases/… @innovationwonk @RimaHabre_ScD @nexusexposomics @DrJBhattacharya @
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@jrkelly You know those fungi that hijack ants' brains and make them jump off trees? Can we engineer those for humans, but for good, not evil?
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DARPA’s magic isn't money - it's the program managers. What if AI could play that role for science, on a much bigger scale?
Second installment of a 4-part series on rebuilding the architecture of science: The AI Program Manager
open.substack.com/pub/catalyzern…
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Sandeep Patel retweetledi
Haven't read this yet but will repost b/c this is a conversation that needs to be happening more. Thanks to @innovationwonk for jumping in. The Vannevar Bush-era system for funding and conducting science is getting replaced -- what shall we replace it with?
Please discuss.
Sandeep Patel@innovationwonk
Science built the modern world. But the world of science needs rebuilding. I’ve launched a new Substack exploring how we can redesign the machinery of science to be faster, fairer, and more intelligent. We're opening with a 4-part opening series: 🧠 Rebuilding the Architecture of Science 🤖 The AI Program Manager 💡 Why Science Needs a Marketplace 📈 From Grants to Portfolios: Index Logic for Science
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The next parts drop next week. Let’s start the conversation about what it will take to rebuild the operating system of science.
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The first piece is out now. It’s about why our current system can’t meet the challenges ahead, and what a new architecture for science could look like.
catalyzernd.substack.com/p/rebuilding-t…
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Science built the modern world.
But the world of science needs rebuilding.
I’ve launched a new Substack exploring how we can redesign the machinery of science to be faster, fairer, and more intelligent.
We're opening with a 4-part opening series:
🧠 Rebuilding the Architecture of Science
🤖 The AI Program Manager
💡 Why Science Needs a Marketplace
📈 From Grants to Portfolios: Index Logic for Science
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Sandeep Patel retweetledi
Ideas matter. Write them down. Around a month ago, @calebwatney sent me a @statnews piece from @Finrow & @innovationwonk & something clicked. I had co-started the Clinical Trial Abundance initiative a few months prior, but the problem seemed intractable.
Ruxandra Teslo 🧬@RuxandraTeslo
The FDA is sitting on a goldmine of drug development data — 10,000+ page dossiers detailing how drugs are designed, made, tested, and approved. Big Pharma has these in-house. Startups? Locked out. It’s time to fix that. Read my proposal for @IFP on how. ifp.org/biotechs-lost-…
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Sandeep Patel retweetledi
FDA has one such huge data repository, currently locked away and sitting idle.
Perhaps easily unlockable albeit with some agency creativity—idea #4 in this piece by me and @innovationwonk in @statnews last week:
x.com/finrow/status/…
Michael Koeris@mkoeris
Concur. We habitually undersample (yes a part is driven by historical data acquisition challenges but those are mostly obsolete now). We also don’t SHARE data - yes I welcome people yelling at me “but we do” <- we don’t and everyone knows it! We need giant repositories of all experimental data. Stand by for some disruption on that. 🫡🇺🇸
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Sandeep Patel retweetledi
Good or bad, when institutions are remade it's an opportunity for fresh new ideas to root.
There's plenty of negative criticism out there—from all sides—but @innovationwonk and I jotted down some constructive ideas to throw into the mix—published here in @statnews
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Sandeep Patel retweetledi
China is outpacing the U.S. in biotech drug approvals, and experts warn that in a race where speed matters, America is stuck in the slow lane — held back by regulatory and operational drag. trib.al/zuJ0CUA
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open.substack.com/pub/sandeeppat…
We desperately need business model innovation in health, targeting a wide array of industries that most influence our collective health and wellbeing, not just healthcare.
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I had a lot of fun talking to @rSanti97 about my time building and leading BARDA DRIVe
Santi Ruiz@rSanti97
BARDA has been called "pound for pound the most effective federal agency" in the response to COVID. Almost no one has heard of it. New Statecraft with @innovationwonk, on running a VC shop in the federal government. statecraft.pub/p/how-to-inves…
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If you were writing a book about VC, what would the title be?
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