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@IFP

A think tank for accelerating scientific, technological, and industrial progress. Follow our team: https://t.co/CC0MxWfh3X

Washington, D.C. Katılım Nisan 2013
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Dan Turner-Evans
Dan Turner-Evans@DanTurnerEvans·
Looking for an even more considered take on the state of modern systems neuroscience? Read my piece in Macroscience, IFP’s fantastic (meta)science newsletter! I explain why systems neuroscience is like the Matrix, delve more into state-of-the-art neuroscience tools, and explain why sustained team science efforts are essential if we someday hope to upload our brains to the cloud. macroscience.org/p/how-close-ar…
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Dan Turner-Evans@DanTurnerEvans

I worked on the fly connectome for over 6 years, and let me just say that y’all have to slow this hype train way down. Connectomes are amazing. Biomechanical models are amazing. Linking the two is awesome. But scientists at the HHMI Janelia Research Campus, Princeton, and other institutes have been working on this for years now, and it’s not clear to me what’s new in the below. And connectomes are still missing a LOT of information. We’ve had the connectome of the worm for over 30 years now, and we still can’t reliably simulate a virtual worm. For example, connectomes don’t capture information about neuromodulator or neuropeptide release sites or receptors. These molecules are constantly changing the properties of neurons in the brain in ways that we have yet to really understand. And we don’t yet understand animal behavior well enough to refine and/or evaluate whole-brain simulations effectively. @AdamMarblestone and @doristsao already made many of these points, as well as many other good ones, but I just wanted to also add my two cents.

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Aidan Mackenzie
Aidan Mackenzie@AidanRMackenzie·
Very useful measure of pre-NEPA delays. Federal agencies measure NEPA timelines from Notice of Initiation (NOI) to Record of Decision (ROD). But sponsors and agencies do years of work *before the NOI. This is widely known but rarely measured. x.com/ThomasHochman/…
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Thomas Hochman@ThomasHochman

Today, @joinFAI and @ShopFloorNAM have a new joint report outlining the permitting barriers to manufacturing in America. We sent a survey out to NAMs 14,000 member companies. The result is a trove of new data and detail on the national permitting picture. 🧵 on findings:

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Thomas Hochman
Thomas Hochman@ThomasHochman·
Leave it to Aidan to immediately find one of my favorite graphics from the report. Indeed, NEPA timelines are a great deal longer than many realize. We usually count from the “notice of intent”… but agencies increasingly spend years on permitting *before* issuing that notice!
Aidan Mackenzie@AidanRMackenzie

Very useful measure of pre-NEPA delays. Federal agencies measure NEPA timelines from Notice of Initiation (NOI) to Record of Decision (ROD). But sponsors and agencies do years of work *before the NOI. This is widely known but rarely measured. x.com/ThomasHochman/…

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Jassi Pannu
Jassi Pannu@JassiPannuMD·
@owl_posting is right that biosecurity spending too often anchors on countermeasures for the last threat, rather than preparing us for the next one. And it's a false choice! Instead, pathogen-agnostic and platform approaches can help us respond to known knowns, known unknowns, unknown unknowns — take your pick.
owl@owl_posting

Reasons to be pessimistic (and optimistic) on the future of biosecurity owlposting.com/p/reasons-to-b… "It was such a fun read (if you can say that about an article on weapons)!" —a glowing review from an early reader this is (once again) the longest article I have ever published at 13,000 words. it involves interviews with 16+ researchers/VC's/policy folks in this field, and discusses basically every single facet of biosecurity that i could find. topics include: how machine-learning in rapid response therapeutic design may work, the financial status of the customer base of biosecurity startups, why agroterrorism feels extremely likely to me, and a lot more i admittedly started the essay pessimistic that this subject matters at all, and i end it surprised that it doesn't keep more people awake at night. im not a doomer about it all, but i can see how people become one. very grateful to the people who decide to spend their career (or some fraction of it) working here, and especially grateful to the ones who helped teach me about the subject

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Joseph Fridman
Joseph Fridman@joseph_fridman·
sometimes you meet someone and you're like "this is going to be amazing" - had deeply immense joy editing with @JassiPannuMD this past week and cannot wait for y'all to see what is cooking
owl@owl_posting

elect @JassiPannuMD to federal office so something like this does not happen again also send her your draft essays to receive thirty, paragraph-long comments, each one of them exceptionally high-signal

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Aidan Mackenzie
Aidan Mackenzie@AidanRMackenzie·
Extremely under told story: NEPA defenders call the law the "Magna Carta of Environmental Law". But Nixon and the 1969 Congress had virtually no idea what they were creating when they passed NEPA. The law was never meant to be a vehicle for litigation or require 1,000+ page reviews. The framers of NEPA wanted to make major changes to protect the environment but they had little to no grasp on the lawsuits or the project-by-project review they were creating. Congress focused their debate on the creation of the Council on Environmental Quality (CEQ) but they barely discussed section 102(2)(C) of NEPA that created the requirement for Environmental Impact Statements (EIS) that now require agencies to produce 1,000+ page reviews. Congress seems to have had no clue that the bill they were passing would become a vehicle for citizen-suits under the APA. NEPA itself has no judicial review section and senior negotiators do not appear to have debated the potential for the law to allow lawsuits against every reviewed project. The bill passed the Senate in July 1969 by unanimous consent — it appears no senator was aware of the bill's far reaching consequences. In December 1969 the bill was rushed through conference so members could go home for Christmas, passing the amended version through Senate without a roll call vote. In a retrospective Professor Lynton Caldwell said: "The disruptive effects of the Act on the business-as-usual economy do not appear to have been foreseen by the Congress or by those interests most likely to have been affected." Nixon's White House seems to have completely missed the costs of the EIS requirement. No WH agencies flagged the costs of the EIS requirement when reviewing the bill. NYTimes coverage of NEPA's passage barely discussed the EIS provision, focusing on an "anti pollution" headline that was inaccurate to the focus of NEPA. The EIS requirement was only mentioned in the second to last paragraph of a companion article. Judicial review was not discussed at all. And nobody foresaw or debated the possibility that CEQ would claim authority to issue binding regulations and expand NEPA far beyond the scope of NEPA's authorization. Categorical exclusions, environmental assessments, rules for community engagement, cumulative impacts, the meaning of major federal action were all invented by CEQ despite Congress never giving them formal authority to issue binding NEPA regs. Far from being the Magna Carta of Environmental Law NEPA is a poorly drafted law that Congress didn't understand before it was passed and has mostly been built out by regulation. fhwa.dot.gov/highwayhistory…
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Will Poff-Webster
Will Poff-Webster@willpoffwebster·
It is a special kind of insanity for a city to make it illegal to build buildings that are the same character as the existing neighborhood, and insist that anything new be smaller than what came before
Andrew DeFrank@andrewdefrank

Zero upzoning proposed beyond existing rowhouse density for very wealthy downtown-adjacent neighborhoods like Capitol Hill and Dupont which are filled with prewar apartment buildings. Buildings at the scale shown below would remain illegal to build where they are today.

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Ruxandra Teslo 🧬
Ruxandra Teslo 🧬@RuxandraTeslo·
I've studied past IRB reform efforts. I am convinced nothing but allowing IRB choice for investigators will work. This would introduce market discipline among IRBs. The great news is I & @matthewesche wrote how to implement this in detail for @IFP.
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Zach Brennan@ZacharyBrennan

FDA commissioner Makary at a CMS conference today in Baltimore calls for “big and different” IRB reforms to catch China's speedy trial starts - pre-IND phase can run 380 days in the US, he said, while China is pushing for 60 days. endpoints.news/makary-pushes-…

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Tao Burga
Tao Burga@taoburr·
Bernie is AGI-pilled. Good. Many to follow. But this response is completely inappropriate. A moratorium on data centers isn't the answer! 95% of this video is him listing quotes from people about how AI will be a huge transformation and very dangerous. True. Imagine a similar call before the Agricultural Revolution (I know, I know, just run with the thought experiment for a moment.): - "This will be the most disruptive change to our way of life, ever" - "We'll become tied to the land, irreversibly changing our social structures" - "People's health may actually grow poorer, due to the loss of nutrient diversity" - "Agriculture will support large cities, which will support large armies and large-scale war" - "Diseases we've never experienced will decimate our population" - "Our societies will become highly unequal" - ... Yes, true! Alright then, what shall we do? A sowing moratorium? Those who sowed eventually outcompeted those who did not. (Yes, even the Mongols and others who, for a while, were an exception.) Similar calls could've been made during the Industrial Revolution, based on similarly real concerns. Those who industrialized outcompeted those who did not. Make no mistake: nations that stunt their intelligence and restrict their labor supply -- potentially by orders of magnitude -- will be outcompeted by those that do not. "Outcompeted," in each of the prior cases, is a euphemism. Weak nations don't have it easy in this world. This is not to say that we should just let it rip "because China." But think of the concrete thing being proposed: a bill to stop building AI data centers in the US. Nowhere else. What will this look like if it succeeds? - The US becomes compute-poor - China overtakes it - Then the scary AI stuff starts happening, first in China, then everywhere else - But now the US has no way of dealing with it at the source (and neither does any other democracy) - The US is degraded to the role the EU has today: expressing concern, and wishing, for its own survival, that her powerful neighbors display more wisdom than ambition The problem is real. But the answer is not a moratorium on US data centers. Unfortunately, a real answer would require more nuance than Bernie can fit into this kind of video, starting with: - Actually funding CAISI, with ~$75M more than the pennies it got for FY26 - Setting up a large R&D program for AI verification, to make sure any regulatory actions the US wants to take in the future can be matched, and verified, in China - Strengthening export controls on AI chips and SME, because you don't want the most transformative technology ever developed to spawn outside democratic control - Real actions on biosecurity: DNA synthesis screening (Cotton and Klobuchar are already on the ball), metagenomic sequencing, 10x the PPE strategic national stockpile - Making the few leading AI labs spend some portion of their compute on AI alignment and control - Launching a lare prize competition for achieving interpretability milestones - Funding serious research on post-AGI economics (super vague but I mean, better to have it than not). The UBI trials were a start, but they fall far short of what we need - Hardening open-source critical infrastructure code against AI-accelerated cyberattacks, - Funding automated vulnerability patching for critical infrastructure, to keep pace with AI-accelerated offensive cyber - Making sure data centers can be built in the US with cheap energy, because if the US can't build them, others will fill the gap - (and many, many more things) There are answers, there are things to do. This stunt is not part of the winning strategy.
Sen. Bernie Sanders@SenSanders

We need a moratorium on AI data centers NOW. Here’s why.

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Connor O’Brien
Connor O’Brien@cojobrien·
This is supposed to be the “Future Land Use Map” but it coincidentally looks exactly the same as the “Current Land Use Map.”
Alex Taliadoros@AlexCTaliadoros

👋 DC housing policy Twitter 🏘️🏗️ The Office of Planning released their *draft* Future Land Use Map earlier today. 🗺️: dc2050.dc.gov/pages/draft-fu… The map will be a big part of the city's next Comprehensive Plan rewrite, "DC 2050." What are your thoughts?

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Connor O’Brien
Connor O’Brien@cojobrien·
Per @AndyMasley's new tool, alfalfa growers in Colorado alone use 16 times as much water each year as all the data centers in the United States.
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Caleb Watney
Caleb Watney@calebwatney·
Neat profile of Taiwan's "Industrial Technology Research Institute", a government-funded lab which helped spin out TSMC and much of Taiwan's chip industry. One of the most impressive industrial policy plays of all time. asteriskmag.com/issues/13/the-…
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Aidan Mackenzie
Aidan Mackenzie@AidanRMackenzie·
Great post by @BenSchifman on a blind spot in the SPEED Act that passed the House. NEPA reform needs to limit vacatur (court remedy at final judgment) AND set limits on preliminary injunctions (court delays at the beginning of litigation). x.com/ThomasHochman/…
Thomas Hochman@ThomasHochman

New on Green Tape: Today, we have a guest post from IFP's @BenSchifman, who spent a decade at the DOJ defending the federal government from NEPA lawsuits. Ben points out a critical omission in many NEPA reform proposals: they don't consider preliminary injunctions. 🧵

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