Inside Precision Medicine

🎧 Behind the Breakthroughs Step into the minds shaping the future of medicine. Listen on your preferred platform: Apple → hubs.li/Q03CQZRK0 Spotify → hubs.li/Q03CQYNy0 IPM → hubs.li/Q03CQYph0 #PrecisionMedicine #BehindTheBreakthroughs #MedTech #Biotech

A key moment from Behind the Breakthroughs Ep. 37 @GrinsteinJ speaks with @Markus_Warmuth, MD, CEO of @MonteRosaTx, about using the cell’s own protein-disposal machinery to eliminate harmful proteins in cancer and autoimmune disease. hubs.li/Q047Dbx40

Breath Test Detects Broad Range of Bacterial Infections Within 10 Minutes A breath test successfully detected #infections in the lungs, blood, muscles, and bone of mice, opening the door to fast and affordable tests @UCSF #breathtests #diagnostics hubs.li/Q047yv2C0

Gut Microbe Metabolites Linked with Heart Disease Bloodstream concentrations of gut microbe metabolites are linked with the development of coronary heart disease, research suggests @VUMCDiscoveries #gutmicrobiome #heartdisease #metabolomics hubs.li/Q047yqJj0

Both Type 1 and Type 2 Diabetes Linked to Increased Dementia Risk People with type 1 diabetes had nearly triple the risk for dementia, while type 2 diabetes doubled risk @BU_Tweets #dementia #diabetes #phenotype #medicalrecords hubs.li/Q047ynGR0

Amyloid Beta–Tau Binding Linked to Microtubule Dysfunction in Alzheimer’s A news study suggests that displacement of tau by Aβ in #microtubules may impair neuronal function before protein aggregation occurs @RyanRJulian @UCRiverside #Alzheimers #amyloid hubs.li/Q047y8d20

Risk-Adapted Prostate Screening Shows Comparable Performance to Mammography Risk-adapted prostate #cancerscreening achieves #biopsy rates and detection of clinically significant cancers comparable to mammography @SigridCarlsson @DKFZ #prostatecancer hubs.li/Q047mswQ0

Probiotic Shows Promise for Treating Bacterial Vaginosis An early study of a probiotic treatment for #bacterialvaginosis shows it is safe, shows good colonization, and has early signs of efficacy @MassGenBrigham #probiotics #clinicaltrials hubs.li/Q047m35N0

Decision-Making Tool Helps Parkinson’s Patients Weigh Deep Brain Stimulation Treatment An evidence-based decision aid helps people with #Parkinsonsdisease determine whether to pursue DBS to manage their motor symptoms @CUAnschutz #DBS #motorsymptoms hubs.li/Q047lKfy0

Smart Watches Spot Early Insulin Resistance Continuously collecting information during routine activities using a #smartwatch can detect early signs of #insulinresistance before it is spotted in routine clinical tests @GoogleResearch #biomarkers #diabetes hubs.li/Q047l01C0

Behind the Breakthroughs Ep. 37 @GrinsteinJ speaks with @Markus_Warmuth, MD, CEO of @MonteRosaTx, about molecular glue degraders and how targeted protein degradation may help eliminate pathogenic proteins long considered undruggable. hubs.li/Q047fd8M0 #BiotechPodcast

Benefits of Healthy Lifestyle for Hypertensive Individuals Confirmed Leading a healthy lifestyle reduces risk for cardiovascular disease and diabetes in people with high blood pressure @HarvardChanSPH #cardiovasculardisease #hypertension #diabetes hubs.li/Q0478JfD0

Ultrasound Platform Enables Targeted Intracellular Delivery of PROTACs SonoPIN combines ultrasound and aptamer microbubbles to deliver PROTACs selectively into #cancercells for targeted protein degradation @DukeU #proteindegradation #drugdelivery hubs.li/Q0478ycd0

Reinventing Gene Editing for Safer, More Precise Therapies Amanda Smith, PhD, recently spoke with Damian Doherty about the limitations of current #geneediting technologies and #PencilBiosciences’ modular, break-free approach #genomicmedicine #CRISPR hubs.li/Q0478Lym0

New IPM Live! Redefining Cancer Care: A Conversation with Dr. Nicola Normanno on Comprehensive Genomic Profiling Register now for this FREE IPM Live sponsored by @illumina: hubs.li/Q046N1dr0 #AI #CancerTherapy #Multiomics

E. coli Converts Plastic Waste Into Parkinson’s Drug L-DOPA #Ecoli can transform the PET-derived chemical building blocks from converted post-consumer plastic bottles into the drug compound L-DOPA @Dr_StephenW @EdinburghUni #Parkinsons #bioengineering hubs.li/Q0476XSR0

Molecular Imaging Halves Prostate Cancer Biopsies in Phase III Trial #PSMA PET/CT scanning could reduce the number of people with suspected #prostatecancer who need a biopsy following inconclusive MRI results @ButeauJames @PeterMacCC #diagnosticimaging hubs.li/Q046W_1R0

AI Model Predicts Telomere Length from Routine Biopsy Images A deep learning model called TLPath can estimate telomere length from routine histopathology slides, enabling scalable studies of aging @Sanjusinha7 @sbpdiscovery #AI #aging #biopsy #telomeres hubs.li/Q046WGZ-0

Immune-Activating Skin Cream Suppresses Squamous Cell Carcinoma The topical cream works by inhibiting LSD1, an enzyme that suppresses immune-activating pathways in epidermal cells @PennMedicine #drugdelivery #skincancer #immuneresponse hubs.li/Q046VWkf0

Antibiotic, Anti-Inflammatory ALS Therapy Shows Promise at Phase II A treatment that combines celecoxib with ciprofloxacin may help improve symptoms and prolong survival in people with ALS @NeurosenseT #ALS #antiinflammatorydrugs #antibiotics hubs.li/Q046Wz6g0

Genetic Colorectal Cancer Risk Study Aims to Improve Family Screening The Family Communications After Genetic Testing trial will examine how best to increase #genetictesting uptake in relatives of #colorectalcancer patients @FASinicropeMD #cancerscreening hubs.li/Q046NpPQ0