Insigneo Institute

Get to know @cherise_go, Asst Prof at @sheffielduni 🇬🇧. She’s an ELLIS Scholar in the ELLIS Unit Manchester and the ELLIS Program Robust Machine Learning. Her area of research is in AI and machine learning for healthcare. #WomenInELLIS

When people with diabetes and high blood pressure develop chronic kidney disease, determining which condition is damaging the kidneys often requires an invasive biopsy. To evaluate whether this distinction could be made without biopsy, researchers extended a whole-body vascular model with a detailed renal network and used virtual clinical trials to identify cardiovascular biomarkers that differentiate diabetic from hypertensive kidney disease. Key findings included: 🔹 The pulsatility index measured in the main renal artery showed strong diagnostic discrimination, correctly distinguishing diabetic kidney disease from hypertensive kidney disease in most cases. 🔹 Combining pulsatility index with resistive index substantially improved classification performance. 🔹 A three-biomarker combination based on mean, systolic, and diastolic blood flow rates achieved the highest predictive accuracy. If validated in clinical trials, these biomarker strategies could enable clinicians to identify the cause of kidney damage non-invasively. 𝗥𝗲𝗮𝗱 𝗺𝗼𝗿𝗲: link.springer.com/article/10.100… 𝗦𝘁𝘂𝗱𝘆: A Virtual Trial to Identify Cardiovascular Biomarkers for Differentiating Diabetic and Hypertensive Kidney Disease 𝗔𝘂𝘁𝗵𝗼𝗿𝘀: Ning Wang, @oneiseitwopi, @ivanbenvan, and Alberto Marzo @sheffielduni @insigneo @SheffUniEng @SheffMechEng @shefunihealth 𝗦𝘂𝗯𝗺𝗶𝘁 𝘆𝗼𝘂𝗿 𝗺𝗮𝗻𝘂𝘀𝗰𝗿𝗶𝗽𝘁: link.springer.com/journal/10439

@SanoScience Congratulations Maciej!

Congratulations to Maciej Malawski on joining the 2026 VPH Board of Directors! 🎉 We’re proud to see Sano represented among experts shaping the future of #InSilicoMedicine, #ComputationalModelling, and #DigitalHealthcare across Europe. #VPH #OpenScience #SanoScience

Insigneo member Prof Pinaki Bhattacharya on his vision of how in silico medicine can become an integral part of healthcare and building collaborative networks for a digital health innovation ecosystem in this VPH_Society Executive Committee interview series.

📷 Insigneo/Sano Modelathon underway! Sheffield & Kraków teams tackle multiscale modelling (0D-3D) for ischaemic stroke after talks by Prof Malawski, Prof Nowinski, Dr Narata & Dr Marzo. #Modelathon #Sano #AGHUSTCenterOfEnergy #DigitalHealth @AGH_Krakow @EDRMedeso @sheffielduni

🌍 Sano seeks Leader of Medical Imaging & Robotics! Lead AI, robotics & imaging research in Kraków. Independence, clinical collaborations, global impact. Details & apply: sano.science/job-offers/lea… #JoinSano #Hiring #AIinHealthcare #ResearchLeadership #DigitalHealth #ResearchJobs

Check out this @Heart_BMJ podcast with Insigneo member Dr Paul Morris @shefunihealth @SheffieldHosp talking about #WearableDevice technology and how it will impact the future of patient care in #cardiology.

⏰ Deadline Approaching! ⏰ 📅 15 January 2026 Under two weeks to apply for our fully funded PhD project “Engineering an in vitro human embryo implantation platform to study pathologies arising in early pregnancy” at @sheffielduni. #development #endometrium #materialsscience

🔥 First Sano Seminar 2026 – NEXT WEEK! Paweł Sobkowicz analyzes 2025 Nobel Econ Prize: How tech drives growth 👉 Mokyr, Aghion, Howitt 📅 Jan 12, 14:00 CET | Zoom Register: sano.science/seminars/prize… #SanoSeminar #NobelPrize #TechInnovation

❄️ The December Insigneo Newsletter is out now! ❄️ 🔗createsend.com/t/t-D38489A434…

Great to see @VarianFrances & @TheClotDoc have now joined @DrAkshayGaur in appearing on the highly respected @Heart_BMJ podcast with @jhfrudd. Well done all!

@DrMarkMills @Bhrs @EHRAPresident Congratulations @DrMarkMills!

Truly honoured to be certified as a Fellow of the European Heart Rhythm Association (FEHRA). A few years ago, I wouldn’t have believed it! Grateful to all my colleagues who have supported me along the way and to the @BHRS for their support. #EPeeps @EHRAPresident

Great to see @ShefUni_ClinMed @insigneo representation at #EACVI2025. Excellent work from Grace and Megan.

🧠 Join us this Monday (Dec 15, 14:00 CEST) for a #SanoSeminar with Monika Pytlarz from Sano’s Computational #Neuroscience Team Talk: Translating AI into Clinical Practice: Lessons from the Children’s Hospital of PhiladelphiavOnline → sano.science/seminars #MedicalAI #Research

Tomorrow at #BMVC2025 I will chair the Doctoral Consortium from 10:00–13:00 in the Goodwin Room, Cutlers’ Hall (S1 1HG) 🎓@sheffielduni @shefcompsci @BMVCconf Join us to hear talented PhD candidates from around the world, all in the stunning, historic Cutlers’ Hall. ✨

🚀 Shaping the Future of AI + Bio Excited to be invited as one of the top 25 scientists at the UKRI BBSRC AIBIO-UK sandpit on AI + Biosciences. Presented work on Explainable AI for Multimodalities and loved connecting with brilliant researchers across the UK. #AI #BIO #ukri

Exciting interdisciplinary PhD opportunities in Sheffield: Investigating developmental failure and success: tiny.cc/rw7v001 Cellular mechanisms of CO-induced metabolic stress: tiny.cc/ww7v001 Evolution of a GRN underlying avian flight: tiny.cc/1x7v001

2 Days to Go! In Silico Medicine & Beyond: A New VPH Chapter is almost here! In just two days, our community will gather for a milestone event exploring how #DigitalTwins, #AI, and simulation are transforming healthcare. We’re honoured to welcome an incredible lineup of speakers, each bringing a unique lens to the future of in silico medicine: Prof. Liesbet Geris (VPH Director) – presenting a forward-looking vision for VPH and #insilicomedicine over the next decade · Dr Eric Vibert, MD, PhD (Université Paris-Saclay / INSERM) – on digital twins in liver surgery and how technology is transforming the operating room · Tina Morrison (EQTY Lab) – on regulatory innovation and trust as enablers of responsible adoption · Steven Bourke (PersonalPulse) – on the value of mutual creation with patients Together, they’ll explore how science, policy, and clinical practice can work hand-in-hand to bring in silico medicine from research to real-world impact. 📅 This Wednesday, 19 November 2025 🔗 Register register.gotowebinar.com/register/13611… Let’s shape the next chapter of in silico medicine, together.

⏰ Deadline in two weeks! ⏰ Work at the interface of biology + computation to build a virtual human embryo to predict developmental success and failure. Happy to answer questions!