The Intern At Work

Happy Monday Twitterverse! If you've checked out our website recently, you'll notice a "Support Our Pod" button, let us explain! Here at the I@W, we are committed to bringing you a high-quality, evidence-based podcast on IM topics meant to serve you better on the wards & on call

📚New Heme Onc Trial Files Throwback! 🧬Ibrutinib improved frontline outcomes and questioned the role of ASCT 💊Acalabrutinib+R-CHOP showed outstanding response rates 👥Acalabrutinib+BR prolonged PFS in older patients with MCL 🔗hemeonctrialfiles.substack.com/p/heme-onc-tri… #HemeOnc #MedTwitter

🚨 New Intern at Work episode! ⚠️ An Approach to Anaphylaxis Learn how to: 💉 Recognize anaphylaxis 🩺 Use IM epinephrine appropriately 🏥 Manage observation and discharge ✍️ Educate patients before they leave 🎧 Listen: medicinepods.com/the-intern-at-… #FOAMed #MedEd #Anaphylaxis

📚Nephro Trial Files Throwback! 🩺Finerenone reduced CKD progression and CV events in T2DM 🩸STARRT-AKI found no benefit to accelerated dialysis initiation 💧High-dose hemodiafiltration reduced mortality vs conventional HD 🔗nephrotrialfiles.substack.com/p/nephro-trial… #Nephrology #MedTwitter

📚New Critical Care Trial Files Throwback! 🫁ACURASYS suggested benefit with early paralysis ⚖️Routine neuromuscular blockade = no mortality benefit 🔄Early prone positioning dramatically improves survival in severe ARDS 🔗criticalcaretrialfiles.substack.com/p/critical-car… #CriticalCare #MedTwitter

📚New Cardio Trial Files! 🫀LAA closure was noninferior to NOACs & ↓ bleeding in AF 🩺IVUS-guided PCI had no advantage over angiography for left main PCI ⚡Sodium bicarb didn't improve ROSC in in-hospital cardiac arrest 🔗cardiotrialfiles.substack.com/p/cardio-trial… #CardioTwitter #MedTwitter

📚New IBD Trial Files! ✂️Surgery vs infliximab for localized ileal Crohn's 📊LIR!C showed similar short-term outcomes, while the 10-year follow-up found significantly more patients remained therapy-free after surgery. 🔗ibdtrialfiles.substack.com/p/ibd-throwbac… #IBD #GITwitter #MedTwitter

📚New Trial Files! 🫀Sodium bicarb didn't improve ROSC in in-hospital cardiac arrest ⚖️Continuing tirzepatide maintained greater long-term weight loss ❤️Stopping β-blockers after MI with preserved EF was noninferior to continuing 🔗 trialfiles.substack.com/p/trial-files-… #MedTwitter #FOAMed

🦴 New episode of The Intern at Work is out now! An evidence-based approach to osteoarthritis: ✅ Diagnosis ✅ Conservative management ✅ Pharmacologic therapy 🎧 medicinepods.com/the-intern-at-… #MedEd #FOAMed #Osteoarthritis #InternalMedicine

📚 AllergyImm Trial Files #Throwback 💉 SC C1 inhibitor reduced HAE attacks 🌾 Ragweed SLIT improved seasonal allergy symptoms 👃 EDS-fluticasone reduced nasal polyps and congestion 🔗 allergyimmtrialfiles.substack.com/p/allergy-and-… #Allergy #Immunology #MedTwitter #FOAMed

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🎙️ New Intern at Work episode! More Than Mouth Ulcers: An Approach to Behçet Disease 🔹 Recognizing Behçet disease 🔹 Key clinical features 🔹 Diagnosis & workup 🔹 Treatment strategies 🎧 medicinepods.com/the-intern-at-… #MedEd #Rheumatology #InternalMedicine #BehcetDisease

📚Thrombo Trial Files #ThrowbackThursday 🩸Standard > low-intensity warfarin for recurrent VTE prevention ⚖️Extended warfarin reduced recurrence vs placebo 💊Aspirin offered modest protection after anticoagulation 🔗 thrombotrialfiles.substack.com/p/thrombo-tria… #Thrombosis #VTE #MedTwitter #FOAMed

📚Heme Onc Trial Files 🧬PETALs: Nilotinib+Peg-IFN improved deep molecular responses in CML 🩸Dasatinib failed to improve outcomes in CBF-AML 🔬Multiple GvHD prophylaxis strategies performed similarly in haploidentical transplant 🔗hemeonctrialfiles.substack.com/p/heme-onc-tri… #HemeOnc #MedTwitter

📚 Diabetes Trial Files #Throwback 🩺 BPROAD: Intensive BP control reduced CV events in T2DM 🩺 FIDELIO-DKD: Finerenone slowed CKD progression 🏃 Lifestyle intervention reduced diabetes risk by 58% 🔗 diabetestrialfiles.substack.com/p/diabetes-tri… #Diabetes #MedTwitter #FOAMed

📚Cardio Trial Files #Throwback 💊EPIC-CAD: Edoxaban alone ↓ bleeding vs dual therapy in AF + CAD 🩺SUSTAIN-6: Semaglutide ↓ CV events in T2DM ❤️ISCHEMIA: No benefit of routine invasive management in stable CAD 🔗cardiotrialfiles.substack.com/p/cardio-trial… #Cardiology #FOAMed #MedTwitter #EBM

🎙️ New Intern at Work episode What are the complications of sickle cell disease you can't afford to miss? 🩸 Vaso-occlusive crisis 🚨 Acute chest syndrome 🧠 Stroke 💉 Transfusion strategies 🎧 medicinepods.com/the-intern-at-… #MedEd #MedTwitter #Hematology

📚New Critical Care Trial Files! 🦠Neostigmine showed promise in septic shock 💊Mega-dose esomeprazole showed no benefit in sepsis 🛏️Restrictive vs liberal restraint use did not improve delirium/coma-free days 🔗criticalcaretrialfiles.substack.com/p/critical-car… #CriticalCare #ICU #Sepsis #MedTwitter

📬 Stay in the Loop with Medicine Pods! Sign up for our monthly newsletter at medicinepods.com to get the latest podcast episodes and medical infographics, delivered straight to your inbox! #MedEd #MedTwitter

📚Trial Files #Throwback 🩸CARAVAGGIO → Apixaban ≈ dalteparin for cancer-associated VTE 🩺DAPA-CKD → SGLT2i ↓ kidney failure & death ❤️PARADIGM-HF → Sacubitril-valsartan > enalapril in HFrEF 🔗trialfiles.substack.com/p/trial-files-… #MedTwitter #EBM #Cardiology #Nephrology #Thrombosis

🩸 Heme Onc Trial Files #ThrowbackThursday 💉 DETERMINATION → ASCT improves PFS 🧬 IKEMA → isatuximab boosts outcomes in relapsed MM 💊 Len maintenance → major PFS benefit post-transplant 🔗 hemeonctrialfiles.substack.com/p/heme-onc-tri… #MultipleMyeloma #Hematology #MedTwitter #EBM