The Intern At Work

Happy Monday Twitterverse! If you've checked out our website recently, you'll notice a "Support Our Pod" button, let us explain! Here at the I@W, we are committed to bringing you a high-quality, evidence-based podcast on IM topics meant to serve you better on the wards & on call

🩺 New Nephro Trial Files! 💊 Finerenone in T1DM+CKD → reduced albuminuria 🩸 Team-based HTN care → better BP control 🧪 Monlunabant in DKD → no clear benefit 🔗 nephrotrialfiles.substack.com/p/nephro-trial… #Nephrology #KidneyTwitter #MedTwitter #EBM

🫀 New Cardio Trial Files! 💊 Stopping beta-blockers post-MI → no increase in events 🫀 Early surgery for asymptomatic severe AS → lower CV mortality 🩻 Immediate vs deferred PCI in STEMI → similar outcomes 🔗 cardiotrialfiles.substack.com/p/cardio-trial… #Cardiology #MedTwitter #EBM

🧠 New IBD Trial Files! 🧬 Stem cells for fistulas → no benefit 💉 Ustekinumab dose ↑ → no added efficacy ⚖️ More treatment ≠ better outcomes in IBD 🔗 ibdtrialfiles.substack.com/p/ibd-trial-fi… #Crohns #IBD #MedTwitter #EBM

🎙️ New Intern at Work episode! 🧬 Alpha-1 antitrypsin deficiency 🫁 + 🫀 Lung–liver connection 🔍 When to test + how to manage High-yield + commonly missed 👀 🎧 Listen here: podcasts.apple.com/ca/podcast/lun… #MedTwitter #InternalMedicine #Pulm #Hepatology

🫁 New Critical Care Trial Files! 💉 Rivers 2001 → ↓ mortality with EGDT 🔁 ARISE + ProMISe → no benefit vs usual care ⚖️ Protocols matter less than early, high-quality care. 🔗 criticalcaretrialfiles.substack.com/p/critical-car… #Sepsis #ICU #EBM

📊 New Trial Files! 💊 4th DM drug > metformin uptitration for A1c 🦠 Continue immunomodulators during infection? ≈ same risk 🩸 Apixaban < bleeding vs rivaroxaban ⚖️ Smarter escalation + safer choices matter. 🔗 trialfiles.substack.com/p/trial-files-… #MedTwitter #EBM #Diabetes #VTE

🌿 New Allergy & Immunology Trial Files! 🧴 Ruxolitinib cream → major improvement in hand eczema 🦠 Probiotic SYN-53 → ↓ allergy symptoms (dose/diversity matter) 🧬 Picankibart → PASI90 in ~80% 🔗 allergyimmtrialfiles.substack.com/p/allergy-and-…

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🩸 New Thrombo Trial Files! 🦵 EVT for PTS → ↓ symptoms but ↑ bleeding 💊 Apixaban < bleeding vs rivaroxaban 🫀 Continue OAC in TAVI? ↑ bleeding, no clear benefit ⚖️ It’s all about balancing bleeding risk. 🧠 thrombotrialfiles.substack.com/p/thrombo-tria… #VTE #Anticoagulation #Hematology #EBM

🩸 New Heme Onc Trial Files! 🧬 Asciminib ↑ MMR vs TKIs in CML 🧫 Orca-T ↑ GVHD-free survival post-transplant ⏱️ Fixed-duration CLL therapy ≈ continuous Precision + less toxicity + time-limited care. 🧠 hemeonctrialfiles.substack.com/p/heme-onc-tri… #Oncology #Hematology #CLL #CML #EBM

🎙️ New Intern at Work episode! 🫀 Coronary angiography — indications, basics & how to interpret what you see. Quick, high-yield review for the wards. @MedicinePods #MedTwitter #FOAMed #Cardiology #MedEd

🎙️ New Intern at Work episode! 🫁 Cryptogenic organizing pneumonia (COP) — often looks like infection but isn’t. A quick, practical approach to recognition, diagnosis & management in ~12 min. @MedicinePods #MedTwitter #FOAMed #MedEd #Pulmonary #InternalMedicine

🩺 New Diabetes Trial Files! 🧪 Finerenone ↓ albuminuria in T1DM + CKD 💊 Orforglipron > semaglutide for HbA1c ➕ 4th drug > metformin uptitration New options in kidney + glycemic care. 🧠 diabetestrialfiles.substack.com/p/diabetes-tri… #EndoTwitter #CKD #GLP1 #EBM

🫀 Cardio Trial Files #ThrowbackThursday 💊 Prasugrel > ticagrelor in ACS ⚡ Culprit-only PCI ↓ mortality in shock 🧠 FFR-guided PCI ↓ urgent revasc 🧠 cardiotrialfiles.substack.com/p/cardio-trial… #CardioTwitter #PCI #ACS #FFR #EBM

🫁New Critical Care Trial Files! 🎥Video laryngoscopy → ↑ first-pass success 🫀Bronchoscopic trach → no ↓ complications 🫁POCUS for dyspnea → no outcome benefit Better procedures ≠ always better outcomes. 🧠criticalcaretrialfiles.substack.com/p/critical-car… #ICU #FOAMed #POCUS #MedTwitter #EBM

🧠 Trial Files #Throwback 🫀 Repair ≈ replacement for MR (but ↑ recurrence with repair) 🦴 Romosozumab → large ↑ BMD 💉 Higher MAP targets in septic shock ≠ better outcomes 🧠 trialfiles.substack.com/p/trial-files-… #MedTwitter #CriticalCare #Cardiology #EBM

📬 Stay in the Loop with Medicine Pods! Sign up for our monthly newsletter at medicinepods.com to get the latest podcast episodes and medical infographics, delivered straight to your inbox! #MedEd #MedTwitter

🩸 Heme Onc Trial Files #ThrowbackThursday ⚖️ DA-EPOCH-R ≠ better than R-CHOP (↑ toxicity) 🧬 DA-EPOCH-R useful in MYC-rearranged disease 📉 4 cycles R-CHOP ≈ 6 cycles in low-risk DLBCL 🧠 hemeonctrialfiles.substack.com/p/heme-onc-tri… #Oncology #Lymphoma #DLBCL #EBM

Nephro Trial Files #ThrowbackThursday 🧪 Bardoxolone ↑ eGFR (but safety concerns) 💧 Ultrafiltration worse than diuretics in cardiorenal HF 🧬 Rituximab ≈ cyclophosphamide in ANCA vasculitis nephrotrialfiles.substack.com/p/nephro-trial… #Nephrology #CKD #HF #Vasculitis #EBM

🫀New Cardio Trial Files! 💊Ticagrelor ≠ noninferior to prasugrel in DM + multivessel CAD ⚡Rivaroxaban ≈ aspirin post-AF ablation (↑ bleeding) 💉Evolocumab ↓ first CV events (primary prevention) 🧠cardiotrialfiles.substack.com/p/cardio-trial… #CardioTwitter #PCI #AFib #EBM