IonOptix

A recent study links N-terminal acetylation dysregulation to cardiac arrhythmia and cardiomyopathy. Using patient-derived iPSC-CMs and the IonOptix Calcium & Contractility System, researchers uncovered how NatA mutations disrupt cardiac function. shorturl.at/onfeK

Bloodborne pancreatic amylin may impair cerebral Aβ clearance, contributing to Alzheimer's pathology. Using the IonOptix Vessel Diameter System, researchers showed how amylin affects vascular tone and Aβ pathways. shorturl.at/aH1XN

Loss of Snord116 improves cardiomyocyte performance during ischemic stress. Using living myocardial slices and the IonOptix Cardiac Slice System, researchers showed improved contractility and kinetics during ischemia–reperfusion injury. shorturl.at/nc9o0

A Nature study shows iPSC-CM maturation can be significantly improved by combining metabolic media, nanopatterning, and electrostimulation. Using the IonOptix C-Pace, researchers achieved more adult-like structure, function, and drug response. shorturl.at/DUbfl

Stretch-mediated β₂-adrenergic signaling in cardiomyocytes depends on caveolae. Using the IonOptix CytoCypher MultiCell, researchers showed stretch increases contractility and cAMP via β₂AR—not β₁AR—and is lost when caveolae are disrupted. shorturl.at/AgbtN

Mechanical loading reveals hidden cardiomyocyte stiffness in cardiometabolic disease. Using IonOptix MyoStretcher and Calcium & Contractility systems, researchers found HFSD-fed mice had stiffer cells and slower Ca²⁺ decay—signs of diastolic dysfunction. shorturl.at/xDazR

A recent study reveals how a titin mutation alters thick filament length, driving dilated cardiomyopathy. Using the IonOptix MyoStretcher and CytoCypher MultiCell Systems, researchers measured changes in force, sarcomere length, and calcium handling. shorturl.at/H9b2r

Researchers modeled hypertrophic cardiomyopathy using human cardiac organoids derived from hiPSC-CMs carrying the MYBPC3 D389V variant. Using the IonOptix CytoCypher MultiCell System, they measured faster contractility and calcium kinetics. shorturl.at/rKqnN

In this Cardiovascular Research study, researchers used IonOptix’s MyoStretcher and MultiCell systems to assess stiffness and calcium handling in cardiomyocytes. Targeting titin isoforms via Rbm20-ASO reduced stiffness and improved diastolic function. shorturl.at/UCf89

Researchers used IonOptix cardiomyocyte systems to study GPR41 function. Butyrate reduced cell shortening and Ca²⁺ transients in WT but not GPR41−/− mice, implicating GPR41 in modulating inotropy via cAMP signaling and SERCA2a activity. Read more: shorturl.at/9TEEr

Researchers used IonOptix cardiomyocyte systems to study GPR41 function. Butyrate reduced cell shortening and Ca²⁺ transients in WT but not GPR41−/− mice, implicating GPR41 in modulating inotropy via cAMP signaling and SERCA2a activity. Read more: shorturl.at/9TEEr

Researchers used the IonOptix CytoCypher MultiCell to compare calcium handling and contractility in hiPSC-cardiomyocytes with or without sympathetic neurons. Coculture enhanced inotropy, chronotropy, and structure—supporting improved maturation. shorturl.at/fldct

Researchers feature IonOptix systems while highlighting the value of intact cardiomyocytes and tissue slices in HFpEF research. Preserving native environments yields more physiologically relevant insights than skinned preps. Read more: shorturl.at/bK3pU

Using the IonOptix MyoStretcher, researchers revealed that diastolic dysfunction in a novel ovary-intact HFpEF mouse model stems from increased stiffness in ventricular myocytes—highlighting a link between menopause and HFpEF. Read more: shorturl.at/T7gse

Researchers use IonOptix cardiomyocyte systems to characterize the role of G-protein-coupled receptor 41 (GPR41) in cardiomyocytes. This study shows that butyrate, a GPR41 agonist, reduces cell shortening & Ca²⁺ transients in WT but not GPR41−/− mice. shorturl.at/IAxiX

Researchers use the IonOptix CytoCypher MultiCell System to show that the MYBPC3 D389V variant induces hypercontractility in cardiac organoids, modeling HCM pathogenesis. Findings suggest mavacamten reverses these effects. Read more: mdpi.com/2073-4409/13/2…

🫀Researchers use IonOptix Calcium and Contractility System to demonstrate that the cardiac myosin ATPase inhibitor aficamten reduces fractional shortening in cardiomyocytes, suggesting a promising therapy for hypertrophic cardiomyopathy. shorturl.at/SyQDI

In this Journal of Molecular and Cellular Cardiology Plus publication from researchers at UVM, Hancock et al. demonstrate a novel method utilizing living myocardial slices to model early and late stage diastole using their IonOptix Cardiac Slice System. shorturl.at/4ShI6

✨ Discover the Future of Cardiac Research with this On-Demand Webinar ✨ Understanding Advanced Cardiac Tissue Slice Applications Dive into the potential of cardiac slices in modern research with our experts! shorturl.at/ayJK9

Check out Dr. Brad Palmer @UVMMedCenter describing the IonOptix Cardiac Slice System at the BHF Cambridge Cardiovascular Research Centre, University of Cambridge @Cambridge_Uni!