Isaac Li

@IsaacLiLab and team show that adding excess decoy DNA protects DNA-based probes from DNase degradation, preserving probe integrity for over 48 hours and enabling robust, long-term mechanobiology studies in live-cell environments #openaccess 🔓 onlinelibrary.wiley.com/doi/10.1002/an…

@SamAytekin Let's go!! 😎🔬🧬🎨

One major drawback of DNA force sensors is their super short lifetime—making them rather unsuitable for most bio studies. Huge congrats (and thanks) to @IsaacLiLab for solving one more problem for the field! Looks like it’s time to image some integrin forces 😎

Latest from the lab:🧬Decoy DNA🧬can extend the lifetime of DNA-based tension probes >24h by outcompeting DNases and preserving signal integrity in live-cell tension imaging - simple, general strategy for robust mechanobiology in DNase-rich environments. doi.org/10.1002/anie.2…

Methods and Applications in Fluorescence MAF 2025 August 24-27 in Montreal Canada Abstract deadline for talk consideration May 12 Abstract deadline for poster presentations June 2 Early Registration deadline June 25 Join us in Montreal for MAF 2025! maf2025.org/en

Check out our recent progress using 🧬 PAINT kinetics to decode molecular tension in super-resolution force imaging! 🔬 Great team effort from Seongho, Adam, Irving, and Kevin! 👏 #DNAPAINT #tension #integrin #superresolution #adhesion doi.org/10.1002/advs.2…

The 10th annual BSC meeting is coming up in Hamilton! Don't miss the April 15 deadline for early registration, abstract submission, and travel awards. Details & program: event.fourwaves.com/bsc2025/ #BSC2025

The 10th annual meeting of the Biophysical Society of Canada will be held May 20-23 at McMaster University in Hamilton, ON. Check out the speaker lineup and programs here: event.fourwaves.com/bsc2025/ Early registration and abstract submission deadlines are April 15. #BSC2025

@Rainmaker1973 12

A considerable number of people get it wrong. Can you solve it?

David Bakker from my group is talking to middle school students about our research on DNA and optical tweezers!🧬Great job, David, for bringing the latest science to the grade 6-10 classrooms! career.sd83.bc.ca/2025/03/14/fro… #biophysics #outreach

We just published a review on recent progress in integrin force loading rate measurement using various molecular tension probes. Learn more about how this has advanced the field and what potential improvement lies ahead here: doi.org/10.1017/qrd.20… #mechanobiology

Celebrate #BiophysicsWeek w/ 3 trainee-organized virtual events to connect, learn, and have fun: 🧠Trivia Night – Mar 24, 6PM ET 🎤Career + Research talk @IsaacLiLab – Mar 27, 1:30PM ET 🥖Biophysical Gastronomy – Mar 29, 2PM ET 📍Register here: @60b81999-0b7f-412d-92a3-e17d8ae9e3e0" target="_blank" rel="nofollow noopener">events.teams.microsoft.com/event/dd0a3371…

The tradition continues! UBCO Chemistry pumpkin carving contest organized by the CGSS! Check them out on FIP 3rd floor! 🎃🎃🎃👻👻👻 @fos_ubco @UBCOGradstudies @bccu_ubco @UBCO_CCU

Free scientific illustrations for biologists! 😍 @NIH has released a library of 500+ free scientific illustrations to create figures, presentations, and illustrations! all freely available in the public domain. Retweet and spread the message! bioart.niaid.nih.gov

Thank you @BiophysCanada, for this recognition! I'm truly honoured to be receiving this award. Huge shoutout to my fantastic team: this wouldn’t have been possible without them. We're excited to see what's coming in the next few years!

This work was spearheaded by two talented PhD students, Micah and David. Their outstanding effort in optimizing the optical trap setup and experiments and developing the theoretical, analytical, and simulation platforms turned a concept into reality. #proudPI

I am excited to share our latest work on creating the first tunable Catch-Bond with #DNA! Our Fish-Hook architecture allowed precise control of adhesion nanomechanics, creating new possibilities for bioengineering and material science! 🧬🐟🪝🌟nature.com/articles/s4146… #biophysics

Applications received by November 15, 2024 will receive full consideration. For a full description and application instructions, see sfu.ca/physics/about-… (For dual-career searches, tenure-track positions in other areas of Physics will be posted to this link soon.)

Yes!!!! So proud of the 🇨🇦 Women's Soccer Team!

@TeamCanada @RC_Sports So proud of them!

Through to the quarter-finals! ⚽ The defending Olympic champions have advanced after a 1-0 win over Colombia 🇨🇦 #TeamCanada | #Paris2024 | @RC_Sports #rcsports #soccer

Our work on Altering Cell Junctional Tension in Spheroids through E-Cadherin Engagement Modulation just got published! We showed that E-cad tension can be monitored and modulated using membrane-anchored DNA probes and strand-displacement reactions! pubs.acs.org/doi/10.1021/ac…