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Isaac Klein
244 posts
Isaac Klein
@isaacbklein
Optimizing how humans think about their health | Co-Founder @whooshwellness
Katılım Nisan 2026
101 Takip Edilen173 Takipçiler
Sorry, I didn’t meant to include ipa there.
My point is: tesa, CJC-no-DAC, and sermorelin ultimately release the same endogenous GH. Tesa just has measured VAT data.
Lack of VAT data for CJC doesn’t mean it doesn’t affect VAT, and lack of sleep data for tesa doesn’t mean it doesn’t affect sleep.
The differences are probably just gh pulse curve and AUC. With the ones I listed.
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3 growth hormone peptides. Most people only need 1.
Tesamorelin - potent for belly fat, but pricey.
Sermorelin - gentle, sleep-focused, but mild.
CJC-1295 + Ipamorelin - more GH, broad results, fraction of the cost.
For most, we start here. Which are you running?
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We are constantly pushing!
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Carter Jenkins@carterwhoosh
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I wonder what the real figure here looks like
Between compounded GLP-1s and RUO
1.5x?.. 2x… or more
Jen Can NuSH@JCanNuSH
Earlier this week, Gallup said that 11% of US adults polled were using GLP-1s. There are around 267 million adults in the US. If that 11% number is “real”, that would be roughly 30 million US patients. The problem: in their last quarterly report (Q1 2026), $LLY said the US incretin market was around 2.4 million a week - or roughly 10 million a month - and that includes T2D and pediatric scripts. So is this just a giant sampling issue, or are 20 million patients on compound or RUO? It’s probably a mix of both, but this potentially points to a big issue for pharma. I will note that the same poll indicated that 68% said they were on branded, but it’s possible patients may be shy or not even know the difference. (I’m sure Lilly and Novo are hoping those responses are honest.) That might indicate the real total number of patients on GLP-1s is closer to around 15 million, with just 5 million on compound. 🤷♀️
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@TheDrMAWZ The cost is too high on a long time horizon.
The shift back to Tirz is already in motion.
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Retatrutide is the most powerful fat-loss compound ever put in humans.
It is also a sympathetic-state drug.
Elevated resting heart rate, suppressed HRV, blunted morning erections in some users.
The fat comes off.
The autonomic cost is real and almost nobody is measuring it.
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@fixtheglitchnow Love this take!
Secretagogues are very underrated
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Unpopular opinion:
HGH is overrated.
It's not a peptide—it's a hormone.
If your goal is longevity, muscle, and recovery, I'd rather stimulate natural growth hormone production with a secretagogue than flood the body with HGH.
Physiology > pharmacology.
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Celebrating all of our US doctors, pharmacies and patients 🇺🇸
Through July 4th, enjoy 60% off site wide with code FREEDOM
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@sondering__ Moreso the lack of food noise + brain glucose metabolism
Totally anecdotal although there’s some interesting early studies though!
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Hot take: Tirz + NAD+ gives me more focus than Semax
Michael Morelli@morellifit
Semax is the closest thing to a limitless pill I've ever taken. It has 40 years of safe Russian clinical use behind it. I've been using it for a few months and the cognitive benefits are insane. Here's the breakdown: (1/16)
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Reta vs Tirz (My n=1 observations so far)
Reta:
- Higher RHR
- Okay sleep quality
- Better fat loss
- More baseline energy
- Little to no post meal crash
- Strong appetite suppression
- Some GI discomfort (at start)
- Faster satiety signaling while eating
- Moderate nootropic/focus effect
- Zero desire for alcohol
Tirz:
- Lower RHR
- Great sleep quality
- Better weight maintenance
- Lower baseline energy
- Occasional post meal crash
- Mild appetite suppression
- Mild GI discomfort (acute after dosing)
- More delayed satiety signaling while eating
- Mild nootropic/focus effect
- Zero desire for alcohol
Reta: 2-2.5mg weekly (6 months, goal: fat loss)
Tirz: 2-3mg weekly (3 weeks, goal: weight maintenance)
(Not medical advice, this information is for research purposes only)
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@isaacbklein Just made the switch last week and my sleeping HR is down 10 BPM and I get more deep sleep which is exactly what I was hoping to achieve.
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I truly believe that in 5 years Tirzepatide is going to be the best all around GLP solution
Reta will be looked at as an aggressive solution for those okay with some trade-offs
Semaglutide in my opinion will be looked at like an artifact in a museum
Tirzepatide… just right 👌
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@isaacbklein Reta for 6 mo -> tirz maintenance is the way to go IMO (and personal experience). The only reason sema will stay strong for a few more years in Canada is that generics are out at $70/mo.
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Carter Jenkins@carterwhoosh
Best start to the week yet. One day this may feel small, but right now it feels huge. Let's have ourselves an epic 4th of July week! Thank you all! Anyway, better late than never to hit the Summer Shred. Enjoy 60% off everything all week w/ code FREEDOM whooshwellness.com
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I truly believe in 5 years that Tirzepatide and Retatrutide will be a thing of the past. We are in a new era with AI and self study. Would not be surprised a single bit to see a GLP compounded that not only has the popular effects that everyone loves from Tirz and Reta… but instead of simply helping the fat to come off someone figures out a way to convert the fat to muscle in a rapid way. Once someone does this both Tirz and Reta will be a thing of the past. Yes, some will likely still use them… but the new shiny thing will hit the scene. People will show insane results and it’ll spread quicker than Retatrutide popularity.
Isaac Klein@isaacbklein
I truly believe that in 5 years Tirzepatide is going to be the best all around GLP solution Reta will be looked at as an aggressive solution for those okay with some trade-offs Semaglutide in my opinion will be looked at like an artifact in a museum Tirzepatide… just right 👌
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@mattbramanti Maybe a hot take but I think Reta will be hard to top
For aggressive weight loss there is maybe not much better
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yeah, this sounds right, until whatever beats reta comes around at which place reta becomes the best all-around
Isaac Klein@isaacbklein
I truly believe that in 5 years Tirzepatide is going to be the best all around GLP solution Reta will be looked at as an aggressive solution for those okay with some trade-offs Semaglutide in my opinion will be looked at like an artifact in a museum Tirzepatide… just right 👌
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@isaacbklein Reta for 6 first months, tirz for maintenance. It has less side effects.
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@isaacbklein I feel like shit on trizepitide. Body aches and disgusting sulpher burps. Conversely, I feel great on semaglutide.
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I truly believe that we are just starting to scratch the surface of what is possible with metabolic engineering, and ALL of these drugs will be looked as primitive overgeneralized solutions in 5 years.
Isaac Klein@isaacbklein
I truly believe that in 5 years Tirzepatide is going to be the best all around GLP solution Reta will be looked at as an aggressive solution for those okay with some trade-offs Semaglutide in my opinion will be looked at like an artifact in a museum Tirzepatide… just right 👌
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@SusanBearry There’s a non-negligible amount of people who even at the lowest dose and more frequent dosing still believe the side effects too intense for long term use
Myself included
The RHR increase was too much for me outside of a 3 month cycle
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@isaacbklein What trade-offs? The side effects of people experience, from what I have read and in my personal experience, are easily mitigated by lowering the dose, or taking smaller doses more frequently.
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