JAMA Cardiology

Among statin-intolerant adults at high cardiovascular risk, #BempedoicAcid was associated with reduced risk of #VenousThromboembolism, including deep vein thrombosis and pulmonary embolism. ja.ma/4gu2Ifc

Meta-analysis indicates #Prasugrel provides optimal balance of efficacy and safety for patients after #PCI, with lower major adverse cardiovascular events and stent thrombosis compared with ticagrelor and clopidogrel. ja.ma/4gMyggz

Maternal diabetes during pregnancy was associated with increased risk of overall #CardiovascularDisease and specific CVD subtypes in offspring, with congenital heart disease, preterm birth, and large for gestational age mediating part of the association. ja.ma/4vt1tAO

In patients with heart failure with mildly reduced or preserved ejection fraction, finerenone consistently lowered systolic blood pressure and reduced cardiovascular deaths and heart failure events, independent of baseline blood pressure. ja.ma/4bgn1sV

Heat-attributable #CardiovascularDisease burden in the US may triple by 2050, with population aging and income disparities amplifying risk, highlighting the need for targeted heat mitigation in vulnerable communities. ja.ma/4vZWxo1

In patients with obstructive #hypertrophic #cardiomyopathy, aficamten improved exercise measures, including peak oxygen uptake and recovery, compared to metoprolol, supporting its use as first-line therapy for symptomatic oHCM. ja.ma/4pwK3lv

📝 Case Report: Dual-phase computed tomography demonstrated acute #cardiac tamponade developing within seconds in a hemodynamically stable patient with type A #aortic dissection, highlighting the need for immediate surgical readiness. ja.ma/4f9lOoE

In patients with heart failure with mildly reduced or preserved ejection fraction, finerenone consistently lowered systolic blood pressure and reduced cardiovascular deaths and heart failure events, independent of baseline blood pressure. ja.ma/44mOHZm

Among adults with Friedreich ataxia cardiomyopathy, intravenous AAVrh.10hFXN gene therapy was well tolerated and associated with increased cardiac frataxin, reduced left ventricular mass index, and lower serum troponin I. ja.ma/4wEkAc8

Hospital adoption of the #Resuscitation Quality Improvement program was not associated with improved #survival to discharge or return of spontaneous #circulation for in-hospital #cardiac arrest. ja.ma/3RbJpNc

In patients with heart failure with mildly reduced or preserved ejection fraction, finerenone consistently lowered systolic blood pressure and reduced cardiovascular deaths and heart failure events, independent of baseline blood pressure. ja.ma/3RpVnTC

💬 Editorial: Projected increases in ambient heat and demographic aging are poised to escalate US #CardiovascularDisease burden, with greatest impact in economically vulnerable and under-adapted regions. ja.ma/4f7vKPu

In patients with heart failure with mildly reduced or preserved ejection fraction, finerenone consistently lowered systolic blood pressure and reduced cardiovascular deaths and heart failure events, independent of baseline blood pressure. ja.ma/4voGWgp

#Lipoprotein(a) genetic risk variants were associated with a higher prevalence of coronary plaque rupture and greater Lp(a) accumulation in culprit thrombotic lesions among individuals with sudden coronary death of European ancestry. ja.ma/44D7PST

Among patients with #ANOCA, multiple endotypes frequently coexist, and a greater number of endotypes identified by coronary function testing was linked with worse angina burden. ja.ma/446jsBH

Among patients with #Type2Diabetes and #ChronicKidneyDisease, finerenone reduced risks of cardiovascular and kidney events and promoted regression of #CKM syndrome regardless of baseline stage. ja.ma/4vEN3y7

A novel provocation test clinically diagnosed #CalciumReleaseDeficiencySyndrome in a family with unexplained sudden cardiac arrest and death, with pause-dependent T-wave changes supporting CRDS risk stratification. ja.ma/4oWl1vD

Both #NonHDLCholesterol and #ApolipoproteinB provided independent, clinically important information for predicting #AtheroscleroticCardiovascularDisease risk, supporting joint assessment of cholesterol content and particle number in risk evaluation. ja.ma/3Tc8QPl

Among adults with Friedreich ataxia cardiomyopathy, intravenous AAVrh.10hFXN gene therapy was well tolerated and associated with increased cardiac frataxin, reduced left ventricular mass index, and lower serum troponin I. ja.ma/3SLA7rO

Precardioversion smartphone #Photoplethysmography monitoring substantially reduced same-day cancellations for scheduled #AtrialFibrillation or flutter cardioversions compared with standard care. ja.ma/4oYoZ74