JAMA Cardiology

#CoronaryCameralFistulas should be considered in patients presenting with myocardial infarction and nonobstructive coronary arteries, as large fistulas can lead to significant cardiac complications. ja.ma/4bi82zc

Low operator procedural volume for transcatheter aortic valve replacement and mitral transcatheter edge-to-edge repair was associated with increased 30-day procedural complications and adverse composite outcomes compared to high-volume operators. ja.ma/4r7rOlI

Premature menopause (age <40 years) was associated with a 40% higher lifetime risk of #CoronaryHeartDisease in both Black and White women, supporting its use as a risk-enhancing factor in preventive care. ja.ma/4sQCrue

In symptomatic patients without known coronary disease, #CCTA-derived plaque burden and volume independently predicted MACE beyond clinical risk and standard imaging findings. ja.ma/4l2k0jL

An estimated 148 million US adults meet FDA-approved indications for at least one #CKM therapy, including 11 million with eligibility for all three medication classes. ja.ma/3OIEYbc

Women with moderate-severe #AorticRegurgitation had higher mortality under medical management, underscoring the need for sex-specific thresholds for left ventricular remodeling. ja.ma/3OGbdYM

💬 Editorial: Price reductions for #PCSK9 inhibitors and #Semaglutide substantially improved cost-effectiveness and access, highlighting the need for value-based drug pricing in cardiovascular care. ja.ma/3OElULj

For US adults eligible for secondary #CardiovascularDisease prevention, #Semaglutide would be cost-effective if annual drug cost is reduced by 18% to $7055 or if current cash price is widely available. ja.ma/4rHK4Db

JAMA Cardiology’s new Editor in Chief Barbara Casadei, MD, DPhil, FMedSci, highlights the journal's commitment to bridging clinical science and public health through rigorous research, innovation in diagnostics and therapeutics, and disease prevention. ja.ma/4cU2CLV

💬 Editorial: Robert O. Bonow, MD, MS, reflects on the first decade of JAMA Cardiology, detailing the journal’s development from its inception, the initial challenges encountered, and its subsequent growth in reach and impact. ja.ma/4rGntqt

💬 Editorial: HeartSync-LBBP found #CSP superior to #BiVP for heart failure outcomes, whereas PhysioSync-HF found CSP inferior, emphasizing the importance of patient selection and operator proficiency. ja.ma/47FIJET

In patients with #HeartFailure and #LBBB, conduction system pacing (#CSP) was inferior to biventricular pacing (#BiVP) for a composite of death, heart failure events, and LVEF change at 12 months. ja.ma/3PgczJP

Among patients with heart failure and LBBB, LBBP demonstrated superior long-term clinical outcomes compared to BiVP, driven primarily by reduced rates of heart failure hospitalization. ja.ma/3PtxDwq

Genotype-positive #FamilialHypercholesterolemia in US adults was linked to higher atherosclerotic cardiovascular disease rates and lower achievement of guideline-recommended LDL-C targets. ja.ma/4s4v9TO

Genotype-positive #FamilialHypercholesterolemia in US adults was linked to higher atherosclerotic cardiovascular disease rates and lower achievement of guideline-recommended LDL-C targets. ja.ma/4sveLvd

Higher aldosterone-renin ratios in older adults were linked to increased risk of atrial fibrillation and ischemic stroke, supporting the aldosterone pathway as a target for cardiovascular disease prevention. ja.ma/46HoAxV

Genotype-positive #FamilialHypercholesterolemia in US adults was linked to higher atherosclerotic cardiovascular disease rates and lower achievement of guideline-recommended LDL-C targets. ja.ma/4s9pHPc

Higher aldosterone-renin ratios in older adults were linked to increased risk of atrial fibrillation and ischemic stroke, supporting the aldosterone pathway as a target for cardiovascular disease prevention. ja.ma/4seQLMK

At 20-year follow-up after patent foramen ovale closure for paradoxical embolism, recurrent stroke was rare (<1%), while bleeding events occurred in 13% and were more frequent among women and those on long-term antithrombotic therapy. ja.ma/404rqta

At 20-year follow-up after patent foramen ovale closure for paradoxical embolism, recurrent stroke was rare (<1%), while bleeding events occurred in 13% and were more frequent among women and those on long-term antithrombotic therapy. ja.ma/4kYmYpg