JAMA Network Open

Among patients with #mCRPC, 43% did not receive bone-modifying agents, with use declining in recent years despite guideline recommendations. #Oncology ja.ma/4wCfTPJ

About 19% of patients opted for home cervical cancer screening; 54% of those returned a sample. Participation was higher in older, White, and previously screened individuals. #CancerScreening ja.ma/4ffJ1pf

Single-dose #psilocybin produced a rapid, sustained #antidepressant effect for more than 3 months in adults with #majordepressivedisorder vs placebo. 📖 Catch more details: ja.ma/4eVWkw7

Following policy changes, more #cancer patients learned of their #diagnosis via the portal, but three-quarters preferred #clinician-led communication, highlighting needs for flexible result release options. #Oncology ja.ma/3RuWnG3

Approximately 7.6% of suicide-related studies registered on ja.ma/4eYnjHq have been discontinued, a rate at the lower end of previously reported #disease-agnostic discontinuation estimates. ja.ma/3RdRlNY

#LLM-based note summarization in the emergency department did not significantly reduce #medical record review time, but most #physicians found it helpful and easy to use. #AI ja.ma/4wDLlNL

#Uninsured rates declined and #Medicaid coverage increased for US adults with #vision impairment, but their out-of-pocket spending ≥10% of income remained more than double that of those without VI in 2024. ja.ma/4vmsqpy

In a cohort study of nearly 3 million patients across 809 clinics, social risk indices calculated at the patient block group or tract were poorly correlated with indices using county or 3-digit ZCTA data. ja.ma/4yfuv9l

#HPV-related #cancer risk in immunosuppressed groups varies by site, #immune status, organ type, and sociodemographic factors, underscoring the need for targeted prevention and management. #HIV ja.ma/4h4MwkD

Low-barrier clinic delivery of long-acting #injectable ART achieved 100% viral suppression in patients with #HIV experiencing homelessness, with high retention using a flexible outreach model. ja.ma/4vtckdQ

Analysis of national prescription claims from 2022 to 2024 found that LAI-CAB comprised a small fraction of US #PrEP use, accounting for 3% of users nationwide. ja.ma/4vYuogU

Among patients with #mCRPC, only 54% received second-line and 26% received third-line therapy. ARPIs dominated early lines; taxanes and Lu-177 use increased in later lines. #ProstateCancer ja.ma/4vrzRfh

Sex-specific optimal #hemoglobin curves in children diverged from World Health Organization #anemia thresholds, with curve-based lower limits often below current cutoffs, especially at younger ages. #Pediatrics ja.ma/4bi8nRW

RCT: Reusable #catheters were noninferior to single-use catheters for #UTIs, with similar safety but higher irritation and discontinuation rates. Patient preference and design improvements remain important. ja.ma/4f8Frgh

Six ED #LLMs showed similar discrimination but different sensitivity and specificity for missed #diagnosis screening, underscoring the need for cohort-specific calibration in #clinical workflows. #AI #EmergencyMedicine ja.ma/4vpGQFo

Comprehensive #smoke-free laws were associated with sustained reductions in #cardiovascular mortality, particularly among older adults, male individuals, and non-Hispanic White populations. ja.ma/4yguxxO

RCT: Among patients with AF-mediated #cardiomyopathy and normalized function after #ablation, phased #GDMT withdrawal led to heart failure deterioration in 13%, while drug adverse events were more common with continuation. ja.ma/44kJ3aj

Only 24% of individuals with hereditary #cancer variants had a family member pursue cascade #genetic testing, with lower uptake especially among racial and ethnic minority groups regardless of cost. ja.ma/4w4IZru

Increasing severity of chronic kidney disease was associated with progressively higher ICU and 90-day mortality, greater risk of kidney replacement therapy, and longer hospital stays after ICU admission. ja.ma/4aIWRyT

Cost-growth benchmark programs were associated with a 2% reduction in per capita health care spending growth, driven by lower hospital and skilled nursing facility expenditures. ja.ma/4pdgrJH